本文選題：環(huán)氧合酶 + 環(huán)氧合酶選擇性抑制劑�。� 參考：《第四軍醫(yī)大學》2005年博士論文

【摘要】：疼痛一直是醫(yī)學研究中的重要課題,除炎性疼痛外,神經(jīng)病理性痛也是疼痛家族的一個重要成員。神經(jīng)病理性痛是由神經(jīng)系統(tǒng)的直接損傷、功能紊亂而引發(fā)的,其病理生理過程很復(fù)雜。神經(jīng)病理性痛與其他疼痛的不同之處在于,即便造成損傷的因素已經(jīng)消除,損傷已經(jīng)消失,疼痛也依然會存在。因此,神經(jīng)病理性痛通常都病程較長,給患者帶來極大痛苦。神經(jīng)病理性痛的治療存在著很多棘手的問題,患者通常對阿片類藥物反應(yīng)不佳,而且由于成癮性問題,不可能長期使用阿片類藥物。由于神經(jīng)元異常放電是神經(jīng)病理性痛發(fā)病的機制之一,因此,一些能夠抑制神經(jīng)元異常放電,穩(wěn)定細胞膜的藥物,如抗抑郁藥和抗驚厥藥,也對神經(jīng)病理性痛有治療作用。但神經(jīng)病理性痛是一個多因素作用的過程,除神經(jīng)元異常放電外,神經(jīng)元的可塑性改變等也與其相關(guān)。因此,單純的細胞膜穩(wěn)定劑還是不夠的。近年來,研究發(fā)現(xiàn)一些前炎性因子,如TNFα,IL-6,IL-10等,都與神經(jīng)病理性痛相關(guān)。環(huán)氧合酶(COX)是催化花生四烯酸轉(zhuǎn)化為前列腺素過程中的關(guān)鍵酶,在炎性過程中起著重要作用。環(huán)氧合酶抑制劑在炎性痛的治療中具有重要的治療價值。環(huán)氧合酶已經(jīng)研究的比較清楚的亞型有兩種:COX-1和COX-2。近年來COX-3也已被分離鑒定。神經(jīng)病理性痛后,脊髓的COX-1和COX-2水平可發(fā)生改變。但目前對環(huán)
[Abstract]:In addition to inflammatory pain, neuropathic pain is also an important member of pain family. Neuropathic pain is caused by direct injury and dysfunction of nervous system, and its pathophysiological process is very complicated. The difference between neuropathic pain and other pain is that even if the cause of the injury has been eliminated, the injury has disappeared, the pain will still exist. Therefore, neuropathic pain usually has a long course and brings great pain to patients. There are many thorny problems in the treatment of neuropathic pain. Patients usually have a poor response to opioid drugs, and because of addictive problems, it is impossible to use opioid drugs for a long time. As abnormal discharge of neurons is one of the mechanisms of neuropathic pain, some drugs that can inhibit abnormal discharges of neurons and stabilize cell membrane, such as antidepressants and anticonvulsants, also have therapeutic effects on neuropathic pain. But neuropathic pain is a multifactor process, and the plasticity of neurons is also related to the abnormal discharge of neurons. Therefore, the simple membrane stabilizer is not enough. In recent years, some proinflammatory factors, such as TNF 偽, IL-6, IL-10 and so on, have been found to be associated with neuropathic pain. Cyclooxygenase (COXX) is a key enzyme in the conversion of arachidonic acid to prostaglandin, which plays an important role in inflammatory process. Cyclooxygenase inhibitors play an important role in the treatment of inflammatory pain. There are two distinct subtypes of cyclooxygenase that have been studied: COX-1 and COX-2. In recent years, COX-3 has also been isolated and identified. After neuropathic pain, the levels of COX-1 and COX-2 in the spinal cord can be changed. But the current ring
【學位授予單位】：第四軍醫(yī)大學
【學位級別】：博士
【學位授予年份】：2005
【分類號】：R363

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