本文選題：氣陰兩虛 + 糖尿病　； 參考：《遼寧中醫(yī)藥大學(xué)》2007年碩士論文

【摘要】： 目的：建立氣陰兩虛型2型糖尿病病證結(jié)合動(dòng)物模型，，探討氣陰兩虛型2型糖尿病病證結(jié)合動(dòng)物模型的造模方法及成模標(biāo)準(zhǔn)。 方法：將60只普通級(jí)Wister大鼠隨機(jī)分為正常對(duì)照組、糖尿病空白對(duì)照組、氣陰兩虛模型組3組。氣陰兩虛模型組大鼠灌服中藥青皮、附子，其余兩組大鼠不做任何處理，連續(xù)4周，然后用中匯糖脈康對(duì)氣陰兩虛模型組大鼠進(jìn)行反證。以大鼠的一般狀態(tài)、血糖、血脂、皮質(zhì)醇、甲狀腺功能(FT_3)、胰島素水平、血栓素B_2、6-酮前列腺素F_(1a)(6-Keto-PGF_(1a))水平以及胰腺、腎臟、腎上腺和甲狀腺的病理作為觀察指標(biāo)。 結(jié)果： 1．中藥造模后氣陰兩虛模型組大鼠出現(xiàn)飲水增多、尿量增多、身體消瘦，精神萎糜，倦怠懶動(dòng)，舌胖大，少津，光滑無苔等癥狀。 2．氣陰兩虛模型組及糖尿病空白對(duì)照組大鼠的血糖、血清甘油三酯(TG)、血清總膽固醇(TC)、低密度脂蛋白(LDL)、皮質(zhì)醇、FT_3、胰島素、血栓素B_2、6-酮前列腺素F_(1a)值與正常對(duì)照組比較均有明顯差異；氣陰兩虛模型組大鼠的血清甘油三酯(TG)、血清總膽固醇(TC)、低密度脂蛋白(LDL)、FT_3、胰島素、血栓素B_2值與糖尿病空白對(duì)照組比較均有顯著差異。氣陰兩虛模型組及糖尿病空白對(duì)照組大鼠胰腺、腎臟、腎上腺和甲狀腺的病理與正常對(duì)照組間有顯著改變，而氣陰兩虛模型組與糖尿病空白對(duì)照組間無顯著改變。 3、經(jīng)反證后：氣陰兩虛模型組大鼠TG、TC、LDL、胰島素、血栓素B_2的水平較反證前有所恢復(fù)且有顯著性差異。 結(jié)論： 在傳統(tǒng)的糖尿病造模方法的基礎(chǔ)上，采用灌服不同性味中藥的方法，以建立與臨床證候相吻合的氣陰兩虛型2型糖尿病病證結(jié)合模型是切實(shí)可行的。 前言 隨著人們生活水平的提高，糖尿病(DM)的發(fā)病率和患病率也日益升高，它已經(jīng)成為繼心腦血管病、腫瘤之后影響人類健康的第三大疾病，所以尋求切實(shí)可行的治療方法已成為擺在眾多醫(yī)學(xué)工作者面前的一項(xiàng)緊迫的任務(wù)。祖國(guó)醫(yī)學(xué)對(duì)糖尿病(消渴)的認(rèn)識(shí)源遠(yuǎn)流長(zhǎng)，在防
[Abstract]:Objective: to establish a combined animal model of type 2 diabetes mellitus with deficiency of qi and yin, and to explore the method and standard of making model of type 2 diabetes mellitus combined with disease and syndrome of deficiency of qi and yin. Methods: 60 normal Wister rats were randomly divided into 3 groups: normal control group, diabetes blank control group, Qi and yin deficiency model group. The rats of Qi-Yin deficiency model group were given Qingpi and aconite, the other two groups did not do any treatment for 4 weeks, then Zhonghui Tangmai Kang was used to reverse the syndrome of Qi and Yin deficiency model group. The general state, blood glucose, blood lipid, cortisol, thyroid function FT _ 3s, insulin level, thromboxane B _ 2oprostaglandin F _ (1) -keto-PGF _ (PGF) _ (1a), and the pathology of pancreas, kidney, adrenal gland and thyroid gland were taken as the indexes of observing the rats' general state, blood glucose, blood lipid, cortisol and thyroid function. Results: 1. The rats of Qi-Yin deficiency model group had symptoms such as drinking water increasing, urine quantity increasing, body wasting, mental wilting, languid and lazy, big tongue, little Tianjin, smooth and no fur, and so on. 2. There were significant differences in blood glucose, serum triglyceride TGN, serum total cholesterol TCU, low density lipoprotein (LDLN), cortisol FT-3, insulin, thromboxane B2O2-ketoprostaglandin Fasta 1a (compared with normal control group) in the model group of deficiency of qi and yin and the blank control group of diabetes mellitus. There were significant differences in serum triglyceride (TGG), serum total cholesterol (TC), low density lipoprotein (LDLX) FT _ 3, insulin, thromboxane B _ 2 between the Qi and Yin deficiency model group and the control group. The pathological changes of pancreas, kidney, adrenal gland and thyroid gland in the model group of deficiency of qi and yin and the control group of diabetes mellitus were significantly different from those in the normal control group, but there was no significant change between the model group of deficiency of qi and yin and the control group of diabetes mellitus. 3, after reverse identification, the levels of TGN TCL, insulin, thromboxane B2 in the model group of deficiency of both qi and yin recovered and had significant difference compared with those before the reverse. Conclusion: On the basis of the traditional diabetic model making method, it is feasible to establish a combined model of type 2 diabetes mellitus with Qi and Yin deficiency syndrome by taking different kinds of Chinese medicine with different sexual flavor. Preface With the improvement of people's living standard, the morbidity and morbidity of DMN (Diabetes Mellitus) are increasing day by day. It has become the third major disease that affects human health after cardio-cerebrovascular disease and tumor. Therefore, seeking practical treatment has become an urgent task for many medical workers. The understanding of diabetes mellitus (quench thirst) in traditional Chinese medicine has a long history.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2007
【分類號(hào)】：R-332

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李平,閻懷士;40例肺氣虛患者血清干擾素活性觀察[J];安徽中醫(yī)學(xué)院學(xué)報(bào);1991年01期

2 劉中本,吳華強(qiáng),趙江云;肺虛證與肺實(shí)證患者血液及支氣管肺泡灌洗液中T淋巴細(xì)胞亞群的比較[J];安徽中醫(yī)學(xué)院學(xué)報(bào);1992年02期

3 趙江云,劉中本,吳華強(qiáng);肺氣虛、肺氣陰兩虛患者T淋巴細(xì)胞亞群的觀察[J];安徽中醫(yī)學(xué)院學(xué)報(bào);1993年01期

4 呂曉英,龍子江,童玉新,白玫,王桐生;頤腦膠囊對(duì)心氣虛模型小鼠中樞神經(jīng)系統(tǒng)的作用[J];安徽中醫(yī)學(xué)院學(xué)報(bào);2002年04期

5 徐紅,錢寶慶,張永華,周錦,陳建成;抗氧化合劑對(duì)虛證患者抗脂質(zhì)過氧化損傷的影響[J];浙江中醫(yī)學(xué)院學(xué)報(bào);1998年03期

6 陳華,嚴(yán)茂祥;脾虛型小兒厭食癥與血漿酪神經(jīng)肽關(guān)系的探討[J];浙江中醫(yī)學(xué)院學(xué)報(bào);1999年03期

7 程志清,龔文波,姚立,唐燁霞,吳玉芙;強(qiáng)迫跑步法建立BALB/c小鼠心氣虛證模型[J];浙江中醫(yī)學(xué)院學(xué)報(bào);2003年06期

8 豐平,王學(xué)江;病證結(jié)合血瘀證動(dòng)物模型研究[J];北京中醫(yī);2000年06期

9 王會(huì)仍,王效婭,劉鐘鹽,馬孔阜;肺氣虛與慢性阻塞性肺病關(guān)系及其本質(zhì)的研究[J];中國(guó)醫(yī)藥學(xué)報(bào);1992年04期

10 熊曼琪,林安鐘,方永奇,朱章志;非胰島素依賴型糖尿病辨證分型與老化度關(guān)系探討[J];中國(guó)醫(yī)藥學(xué)報(bào);1994年03期

本文編號(hào)：1871394