本文選題：離體工作心臟 + ��； 參考：《浙江大學(xué)》2006年碩士論文

【摘要】：目的:通過對兔離體工作心臟停跳前后心功能變化的研究,建立一種能夠進行心腔內(nèi)操作可行的離體心臟模型。 方法:建立兔離體工作心臟模型,固定前后負荷,監(jiān)測心排量及左心室壓力變化,維持心臟停止搏動30min后灌注回復(fù)到工作狀態(tài),比較離體兔心停跳前后心排量(包括主動脈流量,冠脈流量)、dP×HR、平均dP/dTmax(平均室內(nèi)壓最大上升速率)等指標。 結(jié)果:31只實驗?zāi)Ｐ捅怀晒⑵饋?比較離體兔心停跳30分鐘后心排量、dP×HR、平均dP/dTmax等均與停跳前無顯著差異(P0.5)。 結(jié)論:兔離體工作心臟模型在一定時間內(nèi)心功能狀態(tài)穩(wěn)定,更加接近正常心臟生理狀態(tài),是研究各種因素對心功能影響的可采用的實驗平臺。
[Abstract]:Aim: to study the changes of cardiac function before and after cardiac arrest in rabbit working heart in vitro and to establish an isolated heart model which can perform intracardiac operation. Methods: a rabbit model of isolated working heart was established. The changes of cardiac output and left ventricular pressure were monitored before and after fixation, and the perfusion returned to the working state after the cardiac arrest of pulsatile 30min. The indexes of cardiac output (including aortic flow, coronary flow, DP 脳 HRand average DP / dTmax) were compared before and after cardiopulmonary bypass in isolated rabbits. Results 31 experimental models were successfully established. The cardiac output (DP 脳 HR-1) of isolated rabbits after 30 minutes of cardiac arrest was compared. There was no significant difference in average dP/dTmax between the two groups before and after cardiopulmonary bypass (P0. 5). Conclusion: the rabbit model of isolated working heart has stable cardiac function and is closer to the physiological state of normal heart for a certain time. It is a useful experimental platform to study the influence of various factors on cardiac function.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2006
【分類號】：R-332

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相關(guān)期刊論文 前2條

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本文編號：1840225