本文選題：AddaVax + 齲病��； 參考：《口腔醫(yī)學(xué)研究》2014年04期

【摘要】：目的:研究3種不同免疫途徑下,防齲亞單位疫苗聯(lián)合AddaVax佐劑接種小鼠所產(chǎn)生的免疫效果。方法:以rPAc與AddaVax混合物經(jīng)鼻腔滴注、頰黏膜下注射及頸背部皮下注射等3種途徑免疫小鼠,并以rPAc行鼻腔滴注免疫,ELISA法檢測血清和唾液中的特異性抗體水平。結(jié)果:rPAc+AddaVax皮下及頰黏膜下注射方式均可顯著提高小鼠血清中抗PAc IgG水平;rPAc+AddaVax頰黏膜下注射方式可有效提高小鼠唾液中抗PAc IgA水平。結(jié)論:rPAc與AddaVax聯(lián)合經(jīng)皮下及頰黏膜下注射方式可有效提高防齲疫苗的免疫效果。
[Abstract]:Aim: to study the immunological effect of three different immune routes on mice inoculated with anti-caries subunit vaccine and AddaVax adjuvant. Methods: mice were immunized with the mixture of rPAc and AddaVax by nasal drip, submucosal injection under buccal mucosa and subcutaneous injection of neck and back. The specific antibody levels in serum and saliva were detected by nasal drip immunosorbent assay (Elisa) with rPAc. Results the subcutaneous and submucosal injection of AddaVax could significantly increase the level of anti PAc IgG in serum of mice. The submucosal injection of rPAc AddaVax could effectively increase the level of anti PAc IgA in saliva of mice. Conclusion the combination of AddaVax and WRPAc can effectively improve the immune effect of anti-caries vaccine by subcutaneous and submucous injection.
【作者單位】： 武漢大學(xué)口腔醫(yī)學(xué)院教育部口腔生物醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室;
【基金】：國家自然科學(xué)基金項(xiàng)目(編號:304164177)
【分類號】：R392

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