本文選題：膿毒癥　切入點(diǎn)：巨噬細(xì)胞移動(dòng)抑制因子　出處：《浙江大學(xué)》2005年碩士論文　論文類型：學(xué)位論文

【摘要】：背景與目的 巨噬細(xì)胞移動(dòng)抑制子(macrophage migration inhibitory factor,MIF)是一種主要的前炎因子,在膿毒癥、急性呼吸窘迫綜合癥等炎癥性疾病的發(fā)生發(fā)展中起著重要的作用。與TNF、IL-1、IL-6等促炎細(xì)胞因子不同的是,MIF以前體形式儲(chǔ)存于包括垂體前葉細(xì)胞在內(nèi)的多種細(xì)胞胞漿內(nèi),當(dāng)受到創(chuàng)傷、感染、外科大手術(shù)等應(yīng)激刺激時(shí)迅速分泌到胞外。循環(huán)MIF量增加,通過激活和促進(jìn)TNF-α、IL-1β、IL-2、IL-6、IL-8、IFN-γ等炎性細(xì)胞因子表達(dá),NO的釋放和COX-2的誘導(dǎo)等,促使炎癥的進(jìn)一步發(fā)生和擴(kuò)大。此外,MIF能抑制和反向調(diào)節(jié)糖皮質(zhì)激素對(duì)免疫和炎性細(xì)胞活性的抑制及對(duì)炎性細(xì)胞因子釋放的抑制來達(dá)到促炎的目的。膿毒性休克時(shí)炎性細(xì)胞胞漿內(nèi)的MIF合成加強(qiáng)和聚集增加,與炎癥部位炎性細(xì)胞的聚集呈現(xiàn)平行相關(guān)關(guān)系。Bozza等研究觀察到,外科大手術(shù)后機(jī)體血漿中MIF的水平與膿毒癥的發(fā)生、預(yù)后密切相關(guān)。
[Abstract]:Background and purpose. Macrophage migration inhibitory factor MIF is a major proinflammatory factor in sepsis. Inflammatory diseases such as acute respiratory distress syndrome (ARDS) play an important role in the development of inflammatory diseases. Unlike pro-inflammatory cytokines such as TNF-IL-1and IL-6, MIF is stored in the cytoplasm of a variety of cells, including anterior pituitary cells, and is traumatized. The quantity of circulating MIF was increased, and the expression of no and COX-2 was induced by activating and promoting the expression of inflammatory cytokines, such as TNF- 偽, IL-1 尾, IL-2IL-6, IL-8, IFN- 緯, and so on. In addition, MIF can inhibit and reverse regulate the inhibition of glucocorticoid on immune and inflammatory cell activity and the release of inflammatory cytokines in order to promote inflammation. Septic shock. The synthesis and aggregation of MIF in the cytoplasm of inflammatory cells were increased. It was observed that the level of MIF in plasma was closely related to the occurrence and prognosis of sepsis after major surgery.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2005
【分類號(hào)】：R363

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本文編號(hào)：1628657