本文選題：人高遷移率族蛋白1　切入點：膿毒癥　出處：《第一軍醫(yī)大學(xué)》2005年碩士論文　論文類型：學(xué)位論文

【摘要】：研究的目的和意義 膿毒癥(sepsis)指由感染引起的全身炎癥反應(yīng)綜合征(systemic inflammatory response syndrome,SIRS),是各種嚴(yán)重創(chuàng)傷、燒傷、缺氧、再灌注損傷及外科大手術(shù)后常見的并發(fā)癥,進一步發(fā)展可導(dǎo)致膿毒性休克、多器官功能障礙綜合征(multiple organ dysfunction syndrome,MODS),是當(dāng)前創(chuàng)傷外科面臨的棘手難題,已成為臨床危重患者的重要死因之一。近十年來,隨著炎癥反應(yīng)機制研究的不斷深入,人們對于膿毒癥的本質(zhì)與病理過程有了進一步的理解,即認(rèn)識到膿毒癥、嚴(yán)重膿毒癥、膿毒性休克及MODS是反映體內(nèi)一系列病理生理改變及臨床病情嚴(yán)重程度變化的動態(tài)過程,實質(zhì)是機體全身炎癥反應(yīng)不斷加劇、持續(xù)惡化的結(jié)果。嚴(yán)重創(chuàng)傷可以誘發(fā)初期的炎癥反應(yīng),但由于機體產(chǎn)生的多種炎癥介質(zhì)所形成的級聯(lián)效應(yīng),可使炎癥反應(yīng)擴大甚至失去控制,最終導(dǎo)致以細胞自身性破壞為特征的全身性炎癥反應(yīng)。過去普遍認(rèn)為“早期”炎癥介質(zhì)如TNF-a和IL-1是引起多器官損害和死亡的“核心因子”,然而TNF-a和IL-1受體拮抗劑的臨床應(yīng)用并未取得明顯效果。膿毒癥后期,雖然患者病情持續(xù)加重直至死亡,但是TNF-a和IL-1水平往往已恢復(fù)至正常。這提示人們,可能存在某些晚期炎癥介質(zhì)參與了膿毒癥后期的病理生理過程。 1999年,Wang等首次報道高遷移率族蛋白1(high mobility group box-1
[Abstract]:The purpose and significance of the study. Sepsis (sepsis) refers to systemic inflammatory response syndrome caused by infection. It is a common complication of severe trauma, burn, hypoxia, reperfusion injury and major surgery, which can lead to septic shock. Multiple organ dysfunction syndrome (MODS) is a difficult problem in trauma surgery and has become one of the most important causes of death in critically ill patients. There is a further understanding of the nature and pathological process of sepsis, that is, it is recognized that sepsis, severe sepsis, septic shock and MODS are dynamic processes reflecting a series of pathophysiological changes and changes in the severity of clinical conditions in the body. The essence is the result of the continuous worsening of the systemic inflammatory response. Severe trauma can induce the initial inflammatory reaction, but because of the cascade effect of various inflammatory mediators produced by the body, Can cause inflammation to expand or even get out of control, "early" inflammatory mediators such as TNF-a and IL-1 were considered to be "core factors" leading to multiple organ damage and death, whereas TNF-a and IL-1 receptor antagonists. No significant effect has been achieved in clinical application of sepsis in the later stage of sepsis. Although the patient's condition continues to worsen until death, the levels of TNF-a and IL-1 often return to normal, which suggests that some late inflammatory mediators may be involved in the pathophysiological process of late sepsis. In 1999, Wang et al reported for the first time high mobility group box-1 of high mobility group protein 1.
【學(xué)位授予單位】：第一軍醫(yī)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2005
【分類號】：R363

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