本文選題：蛋白激酶Akt　切入點(diǎn)：RNA干涉　出處：《第四軍醫(yī)大學(xué)》2005年碩士論文　論文類型：學(xué)位論文

【摘要】：蛋白激酶Akt是一種蛋白質(zhì)絲氨酸/蘇氨酸激酶,因其與蛋白激酶A和蛋白激酶C具有相對(duì)高的同源性,亦被命名為蛋白激酶B(Protein kinase B,PKB)。它也是病毒癌基因的表達(dá)產(chǎn)物(v-Akt)在細(xì)胞內(nèi)的同源類似物。蛋白激酶Akt在哺乳動(dòng)物中存在三種亞型:Akt1,Akt2和Akt3。蛋白激酶Akt是一個(gè)多結(jié)構(gòu)域蛋白,N端為PH結(jié)構(gòu)域,中心為催化結(jié)構(gòu)域,C端是一個(gè)與PKC調(diào)節(jié)區(qū)類似的區(qū)域。其中PH結(jié)構(gòu)域可以和脂類第二信使PIP_3結(jié)合,使Akt向質(zhì)膜轉(zhuǎn)位而被活化,因此PH結(jié)構(gòu)域?qū)τ贏kt的活化發(fā)揮重要功能。蛋白激酶Akt作為磷脂酰肌醇-3激酶(PI3-kinase)的下游分子,它廣泛參與細(xì)胞各種功能的調(diào)節(jié)。蛋白激酶Akt對(duì)代謝的影響主要表現(xiàn)為促進(jìn)蛋白質(zhì)的合成,促進(jìn)糖原的轉(zhuǎn)運(yùn)。同時(shí)Akt作為一種介導(dǎo)細(xì)胞存活信號(hào)的重要分子,在細(xì)胞凋亡過程中的調(diào)節(jié)作用十分重要,其詳細(xì)作用
[Abstract]:Protein kinase Akt is a serine / threonine protein kinase, and the protein kinase A and protein kinase C has relatively high homology, also called protein kinase B (Protein kinase B, PKB). It is also the expression of viral oncogenes (v-Akt) with source analogs in cells. There are three kinds of protein kinase Akt isoforms in mammals: Akt1, Akt2 and Akt3. protein kinase Akt is a multi domain protein N terminal PH domain, the center for the catalytic domain, C and PKC is a regulatory region of similar regions. The PH domain and the lipid second messenger PIP_3 the binding of Akt to plasma membrane translocation and activation of the PH domain play an important role in the activation of Akt protein kinase Akt as phosphatidylinositol -3 kinase (PI3-kinase) regulates downstream molecules, it is widely involved in cell functions. Effects of protein kinase Akt on the metabolism of the Lord To promote protein synthesis and promote glycogen transport, Akt plays an important role in regulating cell apoptosis and plays an important role in the process of cell apoptosis.

【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2005
【分類號(hào)】：Q55

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本文編號(hào)：1607473