本文關(guān)鍵詞： 乙醇 胰島素抵抗 肝臟 葡萄糖轉(zhuǎn)運體4 AMP活化蛋白激酶 乙醇 睪酮 外周型苯二氮卓受體 雄激素結(jié)合蛋白 過氧化物酶體增生物活化受體a　出處：《山東大學》2005年碩士論文　論文類型：學位論文

【摘要】：背景: 長期攝入乙醇是引起男性不育發(fā)病率逐年增高的重要原因之一。而乙醇損害男性生殖能力的機制目前還未闡明,可能與睪酮的合成、分泌的減少有關(guān)。睪酮是機體始動和維持生精最重要內(nèi)分泌調(diào)節(jié)激素,其合成和分泌主要受下丘腦-垂體-性腺軸調(diào)節(jié)。乙醇可以抑制下丘腦-垂體-性腺軸的活性,這是乙醇抑制睪酮合成和分泌的可能機制之一。近年來研究發(fā)現(xiàn),乙醇還可直接作用于睪丸間質(zhì)細胞,抑制睪酮的合成過程,并且作用環(huán)節(jié)位于睪酮合成的共同通路上,即線粒體合成過程。 PBR,外周型苯二氮卓類受體,在睪丸內(nèi)有廣泛表達,它主要分布在細胞內(nèi)線粒體外膜上,被認為是膽固醇進入線粒體的控制閥。乙醇可影響多種組織PBR的表達:這與多種乙醇相關(guān)疾病的發(fā)生有關(guān)。乙醇是否會影響睪丸間質(zhì)細胞PBR的表達,進而影響睪酮的線粒體合成過程目前還不清楚。 另外,PPARa(過氧化物酶體增生物活化受體a)是PBR表達的正調(diào)節(jié)因子,PPARa的激活劑可以顯著上調(diào)大鼠肝臟PBR的表達。同時有研究發(fā)現(xiàn)乙醇可降調(diào)肝組織PPARa的表達,并且與酒精性脂肪肝的發(fā)生有關(guān)。上述研究進一步提示乙醇可通過影響PPARa,調(diào)節(jié)睪丸組織PBR的表達,進而影響睪酮合成的可能性。 ABP,即雄激素結(jié)合蛋白。是睪酮發(fā)揮生物學效應的重要的調(diào)節(jié)
[Abstract]:Background:. Long-term alcohol intake is one of the important reasons for the increasing incidence of male infertility. However, the mechanism of alcohol impairing male reproductive ability has not been elucidated, and may be associated with testosterone synthesis. Testosterone is the most important endocrine regulating hormone for initiation and maintenance of spermatogenesis. Its synthesis and secretion are mainly regulated by hypothalamus-pituitary-gonadal axis. Ethanol can inhibit the activity of hypothalamus-pituitary-gonadal axis. This is one of the possible mechanisms by which ethanol inhibits the synthesis and secretion of testosterone. In recent years, it has been found that ethanol also acts directly on the stromal cells of the testis and inhibits the synthesis of testosterone, which is located in the common pathway of testosterone synthesis. The process of mitochondrial synthesis. PBR, a peripheral benzodiazepine receptor, is widely expressed in the testis. Alcohol can affect the expression of PBR in many tissues: it is related to the development of many ethanol-related diseases. Whether ethanol affects the expression of PBR in the interstitial cells of testis. It is not clear that the mitochondrial synthesis of testosterone is affected. In addition, PPARAA (peroxisome proliferator-activated receptor a) is a positive regulator of PBR expression. The activator of PPARa can significantly up-regulate the expression of PBR in rat liver. At the same time, it has been found that ethanol can down-regulate the expression of PPARa in liver tissue. These results further suggest that ethanol can regulate the expression of PBR in testis and further influence the possibility of testosterone synthesis by affecting the expression of PBR in testis. ABP, or androgen-binding protein, is an important regulation of testosterone's biological effects.
【學位授予單位】：山東大學
【學位級別】：碩士
【學位授予年份】：2005
【分類號】：R363

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相關(guān)期刊論文 前2條

1 陳家倫;胰島素信號轉(zhuǎn)導及臨床意義(上)[J];國外醫(yī)學.內(nèi)分泌學分冊;2002年01期

2 陳家倫;胰島素信號轉(zhuǎn)導及臨床意義(下)[J];國外醫(yī)學.內(nèi)分泌學分冊;2002年02期

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本文編號：1545649