本文關(guān)鍵詞：P物質(zhì)與神經(jīng)生長因子對正常人外周血中NK細(xì)胞殺傷活性的影響　出處：《中國醫(yī)科大學(xué)》2006年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： P物質(zhì) 神經(jīng)生長因子 NK細(xì)胞 神經(jīng)內(nèi)分泌系統(tǒng) 免疫系統(tǒng)

【摘要】：前言 人們在觀察應(yīng)激對機(jī)體免疫功能影響時發(fā)現(xiàn),應(yīng)激會導(dǎo)致免疫功能低下、自然殺傷細(xì)胞活性受到抑制、淋巴細(xì)胞總數(shù)減少、單核細(xì)胞數(shù)減少等等。神經(jīng)內(nèi)分泌系統(tǒng)對機(jī)體免疫功能具有重要的調(diào)控作用,而經(jīng)典神經(jīng)遞質(zhì)、神經(jīng)肽則是直接作用于免疫活性細(xì)胞和其他參與免疫反應(yīng)細(xì)胞的重要調(diào)節(jié)物質(zhì)。以往有學(xué)者報(bào)道,SP可促進(jìn)增殖細(xì)胞B產(chǎn)生抗體,并刺激單核細(xì)胞產(chǎn)生某些細(xì)胞因子共同參與免疫調(diào)節(jié)作用。有文獻(xiàn)指出,無論是體外孵育還是體內(nèi)給藥,SP均可增強(qiáng)小腸上皮淋巴細(xì)胞中NK細(xì)胞的活性。體內(nèi)給藥能增加脾臟細(xì)胞的殺傷力。并且Hart R等發(fā)現(xiàn)SP能增加人外周血單核樣細(xì)胞的IgM及干擾素的分泌。以上資料均表明P物質(zhì)是體內(nèi)重要的調(diào)節(jié)性多肽,并且對免疫功能具有調(diào)節(jié)作用。神經(jīng)生長因子(nerve growh factor NGF)是一種嗜神經(jīng)多肽,亦是發(fā)現(xiàn)最早和已知最典型的神經(jīng)營養(yǎng)因子。其作為一種為感覺神經(jīng)和交感神經(jīng)元存活分化和功能所必需的神經(jīng)營養(yǎng)多肽在神經(jīng)系統(tǒng)的發(fā)育過程中起關(guān)鍵性作用。隨著研究的發(fā)展和深入,科學(xué)家們發(fā)現(xiàn)神經(jīng)生長因子對免疫系統(tǒng)及免疫應(yīng)答的調(diào)節(jié)也產(chǎn)生重要影響。 NK細(xì)胞是機(jī)體十分重要的細(xì)胞群體,它幾乎參與了免疫系統(tǒng)的發(fā)生、發(fā)展及效應(yīng)等重要環(huán)節(jié)的調(diào)節(jié)過程。目前,對NK細(xì)胞的研究遠(yuǎn)少于T細(xì)胞和B細(xì)胞,而有關(guān)神經(jīng)-內(nèi)分泌-免疫網(wǎng)絡(luò)中NK細(xì)胞所擔(dān)任的角色、功能變化的完整的文獻(xiàn)報(bào)道甚少。Hellstrand等發(fā)現(xiàn)如果NK細(xì)胞經(jīng)過低濃度的腎上腺素預(yù)處理,可以提高NK細(xì)胞的活性,但如果10~(-6)M濃度的腎上腺素與NK細(xì)胞同育,則NK細(xì)胞活性會大大下降。因而,NK細(xì)胞對應(yīng)激原的反應(yīng)是最敏感的。 神經(jīng)生長因子(NGF)和P物質(zhì)(SP)同屬多肽類物質(zhì)。眾多資料表明,二者對免疫功能有明顯的調(diào)節(jié)作用。但關(guān)于二者在體外對人外周血單個核細(xì)胞活性的影響均未見相關(guān)報(bào)道。本實(shí)驗(yàn)研究了SP和NGF對人外周血中
[Abstract]:Foreword When people observe the effect of stress on immune function, it is found that stress can lead to low immune function, inhibition of natural killer cell activity and decrease of total number of lymphocytes. The neuroendocrine system plays an important role in regulating the immune function of the body, while the classic neurotransmitter. Neuropeptides are important regulatory substances acting directly on immunoreactive cells and other immunoreactive cells. In the past, it was reported that SP can promote the production of antibodies in proliferative cells. And stimulate monocytes to produce some cytokines involved in the immune regulation. It has been pointed out that whether in vitro incubation or in vivo administration of drugs. Sp could enhance the activity of NK cells in intestinal epithelial lymphocytes. In vivo administration of SP could increase the cytotoxicity of spleen cells and Hart. It was found that SP could increase the secretion of IgM and interferon in human peripheral blood mononuclear cells. All of the above data indicated that substance P was an important regulatory polypeptide in vivo. Nerve growth factor (NGF) nerve growh factor (NGF) is a neurotropic polypeptide. It is also the earliest and most typical known neurotrophic factor. As a neurotrophic peptide necessary for the survival, differentiation and function of sensory and sympathetic neurons, neurotrophic peptides play a key role in the development of the nervous system. With the development and development of the research. Scientists have found that NGF also plays an important role in regulating the immune system and immune response. NK cells are a very important cell population in the body, which almost participate in the development, development and regulation of the immune system. At present, the study of NK cells is much less than that of T cells and B cells. The role of NK cells in neuro-endocrine-immune networks. There are few reports of functional changes in the literature. Hellstrand et al found that NK cell activity could be increased if NK cells were pretreated with low concentration of epinephrine. However, if the concentration of epinephrine and NK cells were incubated with 10 ~ 10 ~ (-6) 渭 M, the activity of NK cells would decrease greatly, so the response of NK cells to stressors was the most sensitive. Nerve growth factor (NGF) and substance P (substance P) are polypeptides. The effects of SP and NGF on the activity of human peripheral blood mononuclear cells (PBMC) in vitro were not reported. The present study was conducted to study the effects of SP and NGF on the activity of human peripheral blood mononuclear cells (PBMC).
【學(xué)位授予單位】：中國醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2006
【分類號】：R392.12

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