本文關(guān)鍵詞：動(dòng)物實(shí)驗(yàn)性弦脈教學(xué)模型的建立及其評(píng)價(jià)　出處：《北京中醫(yī)藥大學(xué)》2005年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 弦脈 教學(xué)模型 評(píng)價(jià)指標(biāo) 疼痛 去甲腎上腺素

【摘要】：1 目的 本實(shí)驗(yàn)通過(guò)對(duì)家兔疼痛刺激和對(duì)家兔、犬靜脈滴注去甲腎上腺素復(fù)制動(dòng)物弦脈模型,使用 NX-3 型多功能脈圖儀記錄壓力脈圖,對(duì)脈圖時(shí)域參數(shù)進(jìn)行分析并進(jìn)行脈象的屬性歸類,為中醫(yī)脈診教學(xué),也為今后新藥研發(fā)中加入中醫(yī)脈診指標(biāo)作初步的探索。 2 方法 2.1 關(guān)于電學(xué)壓力值與實(shí)際壓力值換算的脈圖儀壓力定標(biāo)實(shí)驗(yàn):NX—3 多功能脈圖儀黑色探頭 1 和黑色探頭 2 上放置 1g、2g、5g、10g、20g、50g、100g、140g砝碼,NX—3 多功能脈圖儀紫色探頭放置 1g、2g、5g、10g、20g、50g 砝碼分別記錄兩種脈圖儀共三個(gè)探頭其空載、探頭上放置砝碼時(shí)脈象采集儀上所顯示的取脈壓力值,驗(yàn)證砝碼重與取脈壓力值的線性關(guān)系。 2.2 給予家兔疼痛性刺激建立弦脈模型 在非麻醉狀態(tài)下將家兔行頸部手術(shù),暴露頸動(dòng)脈,經(jīng)兩名有經(jīng)驗(yàn)的中醫(yī)師雙盲取脈,使用脈圖儀記錄頸動(dòng)脈脈圖,待家兔呼吸平穩(wěn)后再由兩名有經(jīng)驗(yàn)的中醫(yī)師雙盲取脈,確認(rèn)為平脈后在同樣的取脈壓力下記錄頸動(dòng)脈脈圖,對(duì)脈圖參數(shù)進(jìn)行分類后做時(shí)域分析。 2.3 給予家兔、犬靜脈滴注去甲腎上腺素建立弦脈模型 將家兔、犬行頸部手術(shù),暴露頸動(dòng)脈, 待呼吸平穩(wěn)后由兩名有經(jīng)驗(yàn)的中醫(yī)師雙盲取脈,確認(rèn)為平脈后使用脈圖儀記錄頸動(dòng)脈脈圖,再靜脈滴注去甲腎上腺素,再由兩名有經(jīng)驗(yàn)的中醫(yī)師雙盲取脈,確認(rèn)為弦脈后在同樣的取脈壓力下記錄家兔頸動(dòng)脈脈圖,犬的頸、肘和股動(dòng)脈脈圖并,對(duì)脈圖參數(shù)進(jìn)行分類后做時(shí)域分析。 3 結(jié)果 3.1 NX—3 多功能儀黑色探頭 1 砝碼重與電學(xué)壓力值之間 R 值為 0.9993;NX—3 型多功能脈圖儀黑探頭 2 砝碼重與電學(xué)壓力值之間 R 值為 0.9997 ,NX—3 型多功能脈圖儀紫探頭砝碼重與電學(xué)壓力值之間 R 值為 0.9999。三者具有良好的線性關(guān)系。 3.2 家兔、犬教學(xué)用切診部位 3.2.1 家兔 膝關(guān)節(jié)上 8.92±0.12cm 股動(dòng)脈搏動(dòng)處為關(guān)脈 3.2.2 犬 股動(dòng)脈與股骨交叉處為關(guān)脈 3.3 家兔、犬弦股動(dòng)脈指下感覺 3.3.1 家兔:①平脈指感:輕取即得,中取有力,重取反弱;一息 17～18 至;脈來(lái)和緩有力②弦脈指感:一息 14～15 至,脈位較淺,脈形長(zhǎng),脈勢(shì)看緊張度較高,給人以“如按琴弦”的感覺。疼痛型弦脈時(shí)間可持續(xù) 30.07±4.06 分鐘去甲腎上腺素型弦脈在持續(xù)滴注過(guò)程中一直存在。。 3.3.2 犬:①平脈 一息 8～9;輕取既得,中取有力,重取反弱;脈來(lái)平和有力;②弦脈 切脈時(shí)指下感覺與家兔弦脈大致相似,一息 7～8 至,脈位淺,脈形長(zhǎng),搏動(dòng)比家兔甚至人的脈象更有力,脈緊張度高,有“端直以長(zhǎng),如按
[Abstract]:1 purposes
Through the experiments on rabbits and dogs pain stimulation on rabbits, intravenous infusion of noradrenaline to replicate the animal model of type NX-3 string pulse, multifunctional sphygmograph recording pressure pulse graph and attribute analysis of the pulse time domain parameters and pulse classification for TCM teaching, also makes a preliminary study for Chinese medicine research and development of new drugs in the future. The pulse index
2 method
2.1 on the electrical pressure pressure pulse conversion instrument calibration experiment and actual pressure: NX - more than 3 functional sphygmograph black and black 1 probe probe 2 is placed on the 1g, 2G, 5g, 10g, 20g, 50g, 100g, 140g weight, NX more than 3 functional sphygmograph purple probe placed 1g. 2G, 5g, 10g, 20g, 50g were recorded in two Farmar sphygmograph of three probes were placed on the no-load, probe weights pulse acquisition instrument shown on the pressure value, and verification of weight values of the linear relationship between the pulse pressure.
2.2 rabbits given pain stimulation model under anesthesia to establish wiry rabbits underwent neck surgery in the non exposed carotid artery by two experienced doctors with double blind pulse taking, using pulse recorded by carotid pulse, the rabbits breathing smooth again by two experienced doctors with double blind take the pulse, identified as pulse under the same pressure record carotid pulse, time domain analysis to do the classification of pulse parameters.
2.3 rabbits, dogs intravenous infusion of noradrenaline a taut pulse model in rabbits, dogs underwent neck surgery exposed carotid artery, to breathe smoothly by two experienced doctors with double blind pulse taking, confirmed after using pulse pulse recorded by carotid pulse, then intravenous infusion to norepinephrine, again by two experienced doctors take double blind veins, identified as string pulse recorded after rabbit carotid pulse at the same pressure, dog's neck, elbow and femoral arterial Electropulsography and time domain analysis, do the classification of pulse parameters.
3 Results
3.1 NX - more than 3 instrument black probe 1 weight and electrical pressure value R = 0.9993; NX 3 type multifunctional sphygmograph black probe 2 weight and electrical pressure value R value is 0.9997, NX - 3 type multifunctional sphygmograph purple probe weight between electrical and pressure R value of 0.9999. three has a good linear relationship.
3.2 rabbits, dogs with the pulse position of teaching
The 8.92 + 0.12cm femoral artery pulsation in the knee joint of 3.2.1 rabbit is the close pulse
3.2.2 canine femoral artery and interfemoral crossing
3.3 rabbit, the sensation of the canine chord femoral artery
3.3.1: the pulse of a rabbit: in that, in the strong, weak anti refetch; a 17 ~ 18; pulse and strong sense of the string pulse refers to: the rate of 14 to 15, pulse position is shallow, long pulse shape, pulse potential at higher stress degree, give a person "such as the string" feeling. The pain type string pulse time lasting 30.07 + 4.06 minutes norepinephrine type string pulse has been in continuous infusion process.
3.3.2 dogs: a 8 pulse to 9; in both, in the strong, weak anti refetch; pulse flat and powerful; the pulse string pulse when the feeling of finger and rabbit string pulse similar to that of a 7 to 8 to, pulse light, pulse shape, pulse ratio in rabbits even the more powerful pulse, pulse tension high, "straight to long, such as

【學(xué)位授予單位】：北京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2005
【分類號(hào)】：R-332

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