本文關(guān)鍵詞：固醇調(diào)節(jié)元件結(jié)合蛋白（SREBPs）的研究進展　出處：《山東大學》2005年碩士論文　論文類型：學位論文

  更多相關(guān)文章： 固醇調(diào)節(jié)元件結(jié)合蛋白 固醇調(diào)節(jié)元件結(jié)合蛋白裂解激活蛋白 脂肪細胞定向與分化因子1 脂肪細胞分化 膽固醇濃度 代謝綜合征

【摘要】：固醇調(diào)節(jié)元件結(jié)合蛋白(Sterol Regulatory Element Binding proteins,SREBPs)是一類固定于內(nèi)質(zhì)網(wǎng)和核被膜上的膜連接蛋白,具有“堿性螺旋-環(huán)-螺旋-亮氨酸拉鏈”(basic Helix-Loop-Helix-Leucine Zipper,bHLH-Zip)結(jié)構(gòu),屬于bHLH-Zip超家族的一員。已經(jīng)確認的SREBPs成員有3種:SREBP-1a,SREBP-1c,SREBP-2。其中SREBP-1a,SREBP-1c主要調(diào)節(jié)脂肪酸(fatty acid synthase,FAS)、甘油三酯(triglyceride,TG)和葡萄糖代謝相關(guān)酶基因的表達,SREBP-2主要調(diào)控膽固醇代謝。SREBPs在內(nèi)質(zhì)網(wǎng)合成后是無功能的前體,與SREBPs裂解激活蛋白(SREBP Cleavage Activating Protein,SCAP)組成復合物,共同調(diào)控胞內(nèi)膽固醇濃度的動態(tài)平衡。SCAP含有一個固醇敏感區(qū),是哺乳動物脂質(zhì)合成和攝入的中心調(diào)節(jié)因子。SREBP-1c又稱脂肪細胞定向與分化因子1(Adipocyte Determination and Differentiation factor-1,ADD1),在脂肪細胞的分化中發(fā)揮重要作用。通過過氧化物酶體增殖蛋白激活受體(Peroxisome Proliferator-Activated Receptor,PPARs)和CCAAT元件增強結(jié)合蛋白(CCAAT/enhancer binding protein,C/EBPs)共同調(diào)控脂肪細胞的分化。SREBPs還參與脂肪合成基因的營養(yǎng)調(diào)控,并受胰島素/葡萄糖和瘦素等多種激素的調(diào)控,而且介導胰島素對多種基因表達的調(diào)控。最近研究發(fā)現(xiàn),SREBP-1c的過度表達與肝臟和胰島等非脂肪組織的脂質(zhì)積聚相關(guān),是代謝綜合征中重要的基因調(diào)控連接點。對其調(diào)控作用進行全面深入的研究,將對代謝綜合征的發(fā)病機理和指導臨床治療有更新更全面的認識。
[Abstract]:Sterol regulatory element binding protein (Sterol Regulatory Element Binding proteins, SREBPs) is a kind of fixed on the endoplasmic reticulum and nuclear envelope membrane protein on the connection, with the basic helix loop helix leucine zipper "(basic Helix-Loop-Helix-Leucine Zipper, bHLH-Zip), a member of bHLH-Zip superfamily have been identified. SREBPs there are 3 members: SREBP-1a, SREBP-1c, SREBP-2. and SREBP-1a, SREBP-1c mainly regulates fatty acid (fatty acid synthase, FAS), triglycerides (triglyceride, TG) expression and glucose metabolism related enzyme gene, SREBP-2 mainly regulates the cholesterol metabolism in.SREBPs is a precursor to non functional synthesized in endoplasmic reticulum, and cleavage of SREBPs protein (SREBP Cleavage Activating Protein, SCAP) composed of complex, dynamic balance of.SCAP cholesterol concentration of intracellular co regulation contains a sterol sensitive area, is a mammal Lipid synthesis and intake center regulator.SREBP-1c also known as adipocyte determination and differentiation factor 1 (Adipocyte Determination and Differentiation factor-1, ADD1), play an important role in adipocyte differentiation. Through peroxisome proliferator activated receptor protein (Peroxisome Proliferator-Activated, Receptor, PPARs) and CCAAT enhancer binding protein (CCAAT/enhancer binding element protein, C/EBPs) nutritional regulation of common regulation of adipocyte differentiation of.SREBPs is also involved in lipid synthesis genes, and regulated by insulin / glucose and leptin and other hormones, but also mediated the effect of insulin on the expression of various genes. Recent studies suggest that the overexpression of SREBP-1c and lipid accumulation in liver and pancreatic islet and non fat tissue is related to metabolic syndrome gene regulation important syndrome connection point. The modulation effect in depth The research will have a more comprehensive understanding of the pathogenesis of metabolic syndrome and the guidance of clinical treatment.

【學位授予單位】：山東大學
【學位級別】：碩士
【學位授予年份】：2005
【分類號】：R341

【引證文獻】

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2 何珊;海洋深層水對代謝綜合征預防作用的初步研究[D];中國海洋大學;2012年

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2 許會芬;西農(nóng)薩能羊乳腺上皮細胞SREBP-1基因的過表達及干擾研究[D];西北農(nóng)林科技大學;2012年

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本文編號：1364358