【摘要】：在動(dòng)物和人類的整個(gè)生命過程中,血管的結(jié)構(gòu)會(huì)隨著身體組織代謝需求的變化而進(jìn)行連續(xù)的自適應(yīng)調(diào)節(jié)。這些調(diào)節(jié)包括對(duì)血管內(nèi)徑的大小,血管的壁厚,身體組織中毛細(xì)血管的數(shù)量及密度等的調(diào)節(jié)。已有的研究表明,血管內(nèi)壁上的血流剪切力會(huì)刺激血管內(nèi)徑變大,血管自身有固有的縮小趨勢(shì),在血管內(nèi)徑大小的自適應(yīng)調(diào)節(jié)中,這兩個(gè)刺激因素扮演著重要角色。然而僅有這兩個(gè)刺激的自適應(yīng)調(diào)節(jié)是不穩(wěn)定的,并聯(lián)的血管網(wǎng)絡(luò)會(huì)退化為僅剩一條血管的通路。在這篇文章中,我們引入毛細(xì)血管前括約肌的調(diào)節(jié)作用,毛細(xì)血管前括約肌存在于微血管和毛細(xì)血管之間,括約肌的舒張和收縮作用就相當(dāng)于電路里開關(guān)的作用。用包含固有縮小趨勢(shì),剪切力和毛細(xì)血管前括約肌三個(gè)調(diào)節(jié)作用的模型來模擬血管的自適應(yīng)調(diào)節(jié),可以證明血管網(wǎng)絡(luò)的自適應(yīng)調(diào)節(jié)變得穩(wěn)定了。我們的一些結(jié)果有可能解釋高血壓等一些血管病的病因,還可以為血管模擬實(shí)驗(yàn)提供一些參考。
[Abstract]:In the whole life process of animals and human beings, the structure of blood vessels will be adjusted continuously and adaptively with the change of metabolic needs of body tissue. These adjustments include the size of the vessel diameter, the wall thickness of the vessel, the number and density of capillaries in the body tissue, and so on. Previous studies have shown that the shear force of blood flow on the inner wall of blood vessels can stimulate the diameter of blood vessels to become larger and the vessels themselves have an inherent tendency to shrink. These two stimulants play an important role in the adaptive regulation of the diameter of blood vessels. However, only the adaptive regulation of these two stimuli is unstable, and the parallel vascular network will degrade into only one vascular pathway. In this paper, we introduce the regulation of anterior capillary sphincter. Anterior capillary sphincter exists between microvessels and capillaries, and the relaxation and contraction of sphincter is equivalent to that of switch in circuit. It can be proved that the adaptive regulation of vascular network is stable by simulating the adaptive regulation of blood vessels by using the model of inherent reduction trend, shear force and anterior capillary sphincter. Some of our results may explain the etiology of some vascular diseases, such as hypertension, and can also provide some references for vascular simulation experiments.
【學(xué)位授予單位】：上海交通大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：R311

【共引文獻(xiàn)】

相關(guān)博士學(xué)位論文 前2條

1 易蔚;流體切應(yīng)力對(duì)hBMSCs生物學(xué)功能影響及分子機(jī)制研究[D];第四軍醫(yī)大學(xué);2011年

2 劉翼;血管生成素與流體切應(yīng)力在人顱內(nèi)動(dòng)脈瘤形成與破裂中的作用機(jī)制[D];四川大學(xué);2007年

相關(guān)碩士學(xué)位論文 前2條

1 張小龍;大鼠微梗死模型的復(fù)制和雌激素的腦血管保護(hù)作用[D];河北醫(yī)科大學(xué);2003年

2 蔣進(jìn);羅勒水提取物對(duì)血栓閉塞性脈管炎大鼠模型影響的研究[D];新疆醫(yī)科大學(xué);2007年

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本文編號(hào)：2499900