【摘要】：目的探討刺五加腦靈膠囊對氯化鋁致癡呆小鼠的保護作用。方法將60只SPF級昆明種小鼠隨機分為正常對照組、模型組、刺五加腦靈膠囊高、中、低劑量(1.01、0.33、0.10 g/kg)組。采用腹腔注射三氯化鋁建立阿爾茨海默病(AD)小鼠模型。觀察刺五加腦靈膠囊對AD小鼠學(xué)習(xí)記憶能力、乙酰膽堿酯酶(AchE)、乙酰膽堿轉(zhuǎn)移酶(ChAT)和β-淀粉樣蛋白(Aβ)的影響。結(jié)果刺五加腦靈膠囊高劑量組自主活動次數(shù)顯著多于模型組;刺五加腦靈膠囊組上岸時間顯著縮短,錯誤次數(shù)顯著減少;刺五加腦靈膠囊中、高劑量組小鼠腦組織Aβ含量顯著降低,AchE活性顯著降低,ChAT活性顯著增加(均P0.05)。結(jié)論刺五加腦靈膠囊能減少Aβ沉積,增強ChAT活性同時降低AchE活性,對氯化鋁致癡呆小鼠有一定的改善和保護作用。
[Abstract]:Objective to investigate the protective effect of Acanthopanax senticosus Naoling capsule on dementia mice induced by aluminum chloride. Methods 60 SPF Kunming mice were randomly divided into normal control group, model group and Acanthopanax senticosus Naoling capsule high, middle and low dose (1.01, 0.33, 0.10 g/kg). The (AD) model of Alzheimer's disease was established by intraabdominal injection of aluminum trichloride. To observe the effects of Acanthopanax senticosus capsule on learning and memory ability, acetylcholinesterase (AchE), acetylcholine transferase (ChAT) and 尾-starch protein (A 尾) in AD mice. Results the frequency of spontaneous activity in the high dose group of Acanthopanax senticosus Naoling capsule was significantly higher than that in the model group, and the disembarkation time and the number of errors in the group of Acanthopanax senticosus Naoling capsule were significantly shortened. In Acanthopanax senticosus capsule, the content of A 尾 in brain tissue of mice in high dose group was significantly decreased, the activity of AchE was significantly decreased, and the activity of ChAT was significantly increased (all P 0.05). Conclusion Acanthopanax senticosus capsule can reduce the deposition of A 尾, enhance the activity of ChAT and decrease the activity of AchE, which can improve and protect the dementia mice induced by aluminum chloride to a certain extent.
【作者單位】： 北京聯(lián)合大學(xué)應(yīng)用文理學(xué)院食品科學(xué)系;石河子大學(xué)藥學(xué)院藥學(xué)系;
【基金】：北京市教委面上項目(SQKM201411417014) 北京聯(lián)合大學(xué)校級科研項目(ZK70201402)
【分類號】：R285.5;R-332

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