【摘要】：目的:探討在大鼠擠壓綜合征模型下,姜黃素的干預效果研究。方法:利用人工制備的大鼠擠壓模型,測量在不同的擠壓時間下(6、12、24 h)以及在不同劑量[普通劑量組(100 mg/kg)組及高劑量組(200 mg/kg)]姜黃素干預大鼠擠壓綜合征模型的情況下,尿素氮、肌酐、鉀離子的水平,觀察擠壓綜合征的兩大特點:腎功能損傷及高鉀血癥相應情況。結果:對照組、擠壓組、姜黃素普通劑量組(100 mg/kg)和姜黃素高劑量組(200 mg/kg)的數(shù)據(jù)幾乎都出現(xiàn)了一個統(tǒng)一的現(xiàn)象,在尿素氮、肌酐、鉀離子3個項目上,均是在時間屬性上的數(shù)據(jù)出現(xiàn)了統(tǒng)計學差異,并且任意兩個數(shù)據(jù)之間都出現(xiàn)統(tǒng)計學差異(P0.05);在組別的屬性上,4個組別也出現(xiàn)了統(tǒng)計學差異,且任意兩個數(shù)據(jù)之間也都出現(xiàn)統(tǒng)計學差異(P0.05),在尿素氮、肌酐、血鉀3個項目上,以姜黃素用量和不同時間點的對照組、擠壓組、姜黃素普通劑量組(100 mg/kg)和姜黃素高劑量組(200 mg/kg)的數(shù)據(jù)的spearman秩相關分析,可以看出在3個項目的每個時間點的縱向數(shù)據(jù)中,除出現(xiàn)了P0.05的情況,并且r值均小于零。結論:姜黃素在大鼠擠壓綜合征模型中,可以有效的緩解腎功能的損傷,作為一種常見而且廉價的中藥制劑,在擠壓綜合征的治療過程中,值得向更大的范圍推廣。
[Abstract]:Objective: to investigate the intervention effect of curcumin on crush syndrome in rats. Methods: the rat extrusion model was made by artificial method. Urea nitrogen (urea) and creatinine (creatinine) were measured at different extrusion time (6 ~ 12 ~ (24 h) and curcumin at different doses (normal dose (100 mg/kg) and high dose group (200 mg/kg). The level of potassium ion and two characteristics of squeeze syndrome were observed: renal function injury and hyperkalemia. Results: the data of control group, extrusion group, curcumin general dose group (100 mg/kg) and curcumin high dose group (200 mg/kg) almost showed a uniform phenomenon in urea nitrogen, creatinine and potassium ion. There was statistical difference in the data of time attribute, and there was statistical difference between any two data (P0.05). In terms of the attributes of the groups, there were statistical differences among the four groups, and there were also statistical differences between any two data (P0.05), in the urea nitrogen, creatinine, potassium in blood three items, The spearman rank correlation analysis of curcumin dosage and different time points in control group, extrusion group, curcumin general dose group (100 mg/kg) and curcumin high dose group (200 mg/kg) was performed. It can be seen that in the longitudinal data of each time point of the three items, there is a case of P0.05, and the r value is less than zero. Conclusion: curcumin can effectively relieve renal function injury in rat crush syndrome model. As a common and cheap Chinese medicine preparation, curcumin is worth popularizing in the treatment of squeeze syndrome.
【作者單位】： 浙江省立同德醫(yī)院普外科;
【基金】：浙江省中醫(yī)藥科技計劃項目(2014ZA013)
【分類號】：R285.5;R-332

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