發(fā)布時(shí)間：2018-12-09 16:42

【摘要】：鞘氨醇1-磷酸(Sphingosine-1-phosphate,S1P)是一種具有生物學(xué)活性的溶血磷脂信號(hào)分子,在體內(nèi)通過(guò)G蛋白偶聯(lián)受體(G protein coupled receptor,GPCR)家族鞘氨醇1-磷酸受體(S1P receptors)的5個(gè)亞型(S1P1-5)介導(dǎo)多種生物學(xué)功能。S1P4也稱(chēng)內(nèi)皮分化基因受體6(Endothelial differentiation gene receptor 6,Edg-6),主要在淋巴組織和造血組織中表達(dá)。近年的研究發(fā)現(xiàn),免疫細(xì)胞的遷移分化、骨骼肌前體細(xì)胞的遷移、乳腺癌細(xì)胞的增殖、TGFβ1介導(dǎo)的抑制骨骼肌細(xì)胞凋亡均與S1P4相關(guān)。本文將綜述近幾年來(lái)關(guān)于S1P介導(dǎo)S1P4的生理病理應(yīng)答及相關(guān)的信號(hào)轉(zhuǎn)導(dǎo)機(jī)制。
[Abstract]:Sphingosine 1-phosphoric acid (Sphingosine-1-phosphate,S1P) is a biologically active lysophosphatidylolysin signaling molecule, which is coupled with G protein receptor (G protein coupled receptor, in vivo. The five subtypes (S1P1-5) of sphingosine 1-phosphate receptor (S1P receptors) of GPCR family mediate a variety of biological functions. S1P4 is also called endothelial differentiation gene receptor 6 (Endothelial differentiation gene receptor 6 Edg-6), which is mainly expressed in lymphoid and hematopoietic tissues. In recent years, it has been found that the migration and differentiation of immune cells, the migration of skeletal muscle precursor cells, the proliferation of breast cancer cells, and the inhibition of apoptosis of skeletal muscle cells mediated by TGF 尾 1 are all related to S1P4. This paper reviews the physiological and pathological responses and related signal transduction mechanisms of S1P4 mediated by S1P in recent years.
【作者單位】： 內(nèi)蒙古大學(xué)生命科學(xué)學(xué)院;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目(31260210) 內(nèi)蒙古大學(xué)2015年國(guó)家級(jí)大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計(jì)劃項(xiàng)目(201510126042)
【分類(lèi)號(hào)】：R363

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