【摘要】：鞘氨醇1-磷酸(Sphingosine-1-phosphate,S1P)是一種具有生物學(xué)活性的溶血磷脂信號分子,在體內(nèi)通過G蛋白偶聯(lián)受體(G protein coupled receptor,GPCR)家族鞘氨醇1-磷酸受體(S1P receptors)的5個亞型(S1P1-5)介導(dǎo)多種生物學(xué)功能。S1P4也稱內(nèi)皮分化基因受體6(Endothelial differentiation gene receptor 6,Edg-6),主要在淋巴組織和造血組織中表達。近年的研究發(fā)現(xiàn),免疫細胞的遷移分化、骨骼肌前體細胞的遷移、乳腺癌細胞的增殖、TGFβ1介導(dǎo)的抑制骨骼肌細胞凋亡均與S1P4相關(guān)。本文將綜述近幾年來關(guān)于S1P介導(dǎo)S1P4的生理病理應(yīng)答及相關(guān)的信號轉(zhuǎn)導(dǎo)機制。
[Abstract]:Sphingosine 1-phosphoric acid (Sphingosine-1-phosphate,S1P) is a biologically active lysophosphatidylolysin signaling molecule, which is coupled with G protein receptor (G protein coupled receptor, in vivo. The five subtypes (S1P1-5) of sphingosine 1-phosphate receptor (S1P receptors) of GPCR family mediate a variety of biological functions. S1P4 is also called endothelial differentiation gene receptor 6 (Endothelial differentiation gene receptor 6 Edg-6), which is mainly expressed in lymphoid and hematopoietic tissues. In recent years, it has been found that the migration and differentiation of immune cells, the migration of skeletal muscle precursor cells, the proliferation of breast cancer cells, and the inhibition of apoptosis of skeletal muscle cells mediated by TGF 尾 1 are all related to S1P4. This paper reviews the physiological and pathological responses and related signal transduction mechanisms of S1P4 mediated by S1P in recent years.
【作者單位】： 內(nèi)蒙古大學(xué)生命科學(xué)學(xué)院;
【基金】：國家自然科學(xué)基金項目(31260210) 內(nèi)蒙古大學(xué)2015年國家級大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計劃項目(201510126042)
【分類號】：R363

【相似文獻】

相關(guān)期刊論文 前6條

1 張華;樊霞;陳旭義;楊波;;鞘氨醇-1-磷酸受體-1結(jié)合肽的篩選及功能驗證[J];醫(yī)學(xué)研究生學(xué)報;2013年07期

2 馬學(xué)斌;�；拾贝家种贫肆Ｃ富钚缘姆肿訖C制[J];國外醫(yī)學(xué)(腫瘤學(xué)分冊);2002年03期

3 劉立真,唐鎖勤,張曉飛,王建文,黃東生,宋惠雨;α-半乳糖神經(jīng)鞘氨醇對自然殺傷T細胞的激活作用[J];實用兒科臨床雜志;2004年01期

4 郭守東;于楊;馮蕾;劉帥;李和樓;崔英杰;秦樹存;;液-質(zhì)聯(lián)用法對生物樣本中鞘氨醇1-磷酸的微量測定[J];中國動脈硬化雜志;2013年04期

5 李忠堂;從玉文;張慶林;楊日芳;;鞘氨醇-1-磷酸-1型受體選擇性配體研究進展[J];中國新藥雜志;2014年07期

6 ;[J];;年期

，

本文編號：2369709