【摘要】：背景:骨關(guān)節(jié)炎的發(fā)病機制尚不明確,臨床缺乏根治措施,研究重點大部分都放在減輕疼痛、改善關(guān)節(jié)功能等方面。建立動物模型是研究骨關(guān)節(jié)炎病理機制、預(yù)防及治療的重要手段,也是預(yù)防和改善骨關(guān)節(jié)炎保健食品新功能開發(fā)研究的必要方式。目的:綜述骨關(guān)節(jié)炎動物模型的建立及其在預(yù)防骨關(guān)節(jié)炎功能食品研究中的應(yīng)用,以期為正確合理的選擇骨關(guān)節(jié)炎動物模型及生物活性物質(zhì)篩選試驗提供科學(xué)依據(jù)。方法:檢索至2016年5月為止PubMed數(shù)據(jù)(http://www.ncbi.nlm.nih.gov/PubMed)及CNKI相關(guān)期刊論文(http://www.cnki.net/)有關(guān)建立節(jié)炎動物模型的文獻(xiàn),英文檢索詞為"osteoarthritis,animal model",中文檢索詞為"骨關(guān)節(jié)炎,動物模型"。排除重復(fù)性研究,共檢索到157篇相關(guān)文獻(xiàn),59篇文獻(xiàn)符合納入標(biāo)準(zhǔn)。結(jié)果與結(jié)論:(1)骨關(guān)節(jié)炎動物模型的建立方法多種多樣,各種造模方法各有優(yōu)缺點,應(yīng)用范圍也不相同;(2)因此需要選擇和建立合適的骨關(guān)節(jié)炎動物模型,通過動物實驗深入探索骨關(guān)節(jié)炎的發(fā)病機制,篩選出更多可以預(yù)防和改善骨關(guān)節(jié)炎的有效物質(zhì),并開發(fā)出相應(yīng)的功能性食品,以減輕患者的痛苦并提高生活質(zhì)量,具有十分重要的意義。
[Abstract]:Background: the pathogenesis of osteoarthritis is not clear, and the clinical treatment is lacking. Most of the researches focus on alleviating pain and improving joint function. The establishment of animal models is an important means to study the pathological mechanism, prevention and treatment of osteoarthritis, and it is also a necessary way to develop and study the new function of health food for the prevention and improvement of osteoarthritis. Objective: to summarize the establishment of animal model of osteoarthritis and its application in the study of functional food for the prevention of osteoarthritis in order to provide scientific basis for the correct and reasonable selection of animal model of osteoarthritis and the screening test of biological active substances. Methods: PubMed data (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI Chinese Journal Full-text Database) (http://www.cnki.net/) were retrieved to establish the animal model of arthritis. The key words were "osteoarthritis,animal model" in English and "osteoarthritis, animal model" in Chinese. Excluding repeatability, 157 related articles were retrieved, 59 of which met the inclusion criteria. Results and conclusions: (1) there are various methods for establishing animal models of osteoarthritis, and each method has its own advantages and disadvantages, and the scope of application is different. (2) it is necessary to select and establish suitable animal models of osteoarthritis. Through animal experiments to explore the pathogenesis of osteoarthritis, to screen out more effective substances that can prevent and improve osteoarthritis, and to develop the corresponding functional food, in order to alleviate the suffering of patients and improve the quality of life. It is of great significance.
【作者單位】： 北京聯(lián)合大學(xué)應(yīng)用文理學(xué)院生物活性物質(zhì)與功能食品北京市重點實驗室;北京聯(lián)合大學(xué)功能食品科學(xué)技術(shù)研究院;北京綠色金可生物技術(shù)股份有限公司;
【基金】：北京聯(lián)合大學(xué)生物活性物質(zhì)與功能食品北京市重點實驗室開放課題(Zk70201501)~~
【分類號】：R-332;R684.3

【相似文獻(xiàn)】

相關(guān)期刊論文 前4條

1 富琦,范穎,王家輝,張洪鈞,孟素萍,陳信義;免疫性血小板減少性紫癜病證結(jié)合動物模型建立與評價[J];中國中醫(yī)基礎(chǔ)醫(yī)學(xué)雜志;2004年02期

2 王梅,周春祥;腫瘤術(shù)后動物模型建立及其在中醫(yī)藥研究中的應(yīng)用[J];河南腫瘤學(xué)雜志;2005年03期

3 季智勇;史懷璋;徐善才;;顱內(nèi)動脈瘤動物模型建立的研究進(jìn)展[J];中國腦血管病雜志;2008年06期

4 谷俊朝;劉建;俞巍;;卡氏肺孢子蟲肺炎動物模型建立的現(xiàn)狀[J];首都醫(yī)科大學(xué)學(xué)報;2009年05期

相關(guān)會議論文 前1條

1 寇毅;李延青;孟敏;傅海燕;石煥;傅廷亮;閻明憲;;慢性膽源性胰腺炎動物模型建立初步研究[A];2005年全國慢性胰腺炎學(xué)術(shù)大會專集[C];2005年

，

本文編號：2290131