【摘要】：羧基末端調(diào)節(jié)蛋白(carboxyl-terminal modulator protein,CTMP)是一核編碼的線粒體蛋白,表達(dá)于神經(jīng)、胰腺、腎臟等多種組織。病理?xiàng)l件下羧基末端調(diào)節(jié)蛋白轉(zhuǎn)位于胞漿,結(jié)合并抑制蛋白激酶B活性、與熱休克蛋白-70相結(jié)合并解除該分子對(duì)凋亡因子的限制作用,進(jìn)而參與細(xì)胞凋亡、代謝的調(diào)控。研究還發(fā)現(xiàn),羧基末端調(diào)節(jié)蛋白參與線粒體動(dòng)力學(xué)調(diào)節(jié);其羧基端具有硫酯酶活性,又被稱為硫酯酶超家族成員4。本文旨在闡述羧基末端調(diào)節(jié)蛋白的分子結(jié)構(gòu)及其在腫瘤、缺血性損傷和代謝綜合征中作用之研究進(jìn)展。
[Abstract]:Carboxyl terminal regulatory protein (carboxyl-terminal modulator protein,CTMP) is a nuclear encoded mitochondrial protein, expressed in nerve, pancreas, kidney and other tissues. Under pathological conditions, carboxyl terminal regulatory protein was translocated in the cytoplasm, binding and inhibiting the activity of protein kinase B, binding with heat shock protein 70 and releasing the restriction of the molecule on apoptosis factor, thus participating in the regulation of cell apoptosis and metabolism. It was also found that carboxyl terminal regulatory proteins were involved in mitochondrial kinetic regulation and their carboxyl terminals had thioesterase activity and were also known as thioesterase superfamily members. The purpose of this paper is to review the molecular structure of carboxyl terminal regulatory proteins and their roles in tumor, ischemic injury and metabolic syndrome.
【作者單位】： 第四軍醫(yī)大學(xué);第四軍醫(yī)大學(xué)基礎(chǔ)部生理學(xué)教研室;
【基金】：國(guó)家自然科學(xué)基金(31371183)資助課題
【分類(lèi)號(hào)】：R363

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