間充質(zhì)干細胞源外泌體在組織損傷修復中的研究進展
發(fā)布時間:2018-09-18 10:56
【摘要】:正間充質(zhì)干細胞(mesenchymal stem cells,MSCs)具有分化、增殖及自我更新的能力和多向分化的潛能。MSCs能被招募至受損的組織,誘導器官再生,并不是通過轉(zhuǎn)分化機制分化為目的細胞來替代損傷細胞而促進組織功能的恢復,而是通過旁分泌作用向受損的組織周圍釋放細胞因子、生長因子和微泡刺激原始組織細胞進行修復及組織功能特性恢復[1-2]。長期以來,大多數(shù)細胞釋放到胞外間隙的細胞外囊泡
[Abstract]:Mesenchymal stem cells (mesenchymal stem cells,MSCs) have the ability of differentiation, proliferation and self-renewal, and the potential of multi-differentiation. MSCs can be recruited to damaged tissues and induce organ regeneration. It is not by the mechanism of transdifferentiation to replace the injured cells to promote the recovery of tissue function, but by paracrine to release cytokines around the damaged tissues. Growth factor and microbubble stimulated primordial cell repair and recovery of tissue function [1-2]. For a long time, most cells released into the extracellular space of the extracellular vesicle
【作者單位】: 福州總醫(yī)院福建省移植生物學重點實驗室;
【基金】:國家自然科學基金(編號:81370948)
【分類號】:R329.2
[Abstract]:Mesenchymal stem cells (mesenchymal stem cells,MSCs) have the ability of differentiation, proliferation and self-renewal, and the potential of multi-differentiation. MSCs can be recruited to damaged tissues and induce organ regeneration. It is not by the mechanism of transdifferentiation to replace the injured cells to promote the recovery of tissue function, but by paracrine to release cytokines around the damaged tissues. Growth factor and microbubble stimulated primordial cell repair and recovery of tissue function [1-2]. For a long time, most cells released into the extracellular space of the extracellular vesicle
【作者單位】: 福州總醫(yī)院福建省移植生物學重點實驗室;
【基金】:國家自然科學基金(編號:81370948)
【分類號】:R329.2
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