【摘要】：目的了解猴株五日熱巴爾通體的生化特性和藥物敏感性,為進(jìn)一步研究五日熱巴爾通體的耐藥機(jī)制奠定基礎(chǔ)。方法采用E test法,檢測1株五日熱ATCC參考株及10株五日熱巴爾通體猴分離株的生化特性及對14種抗生素的最低抑菌濃度(MIC)。結(jié)果 H15SC對利福平高度耐藥(MIC256),其余菌株敏感;H98SC對克林霉素耐藥,其余菌株敏感;除S13外,其余10株菌株對丁胺卡那霉素、多粘菌素MICs值較高;全部菌株對阿奇霉素、頭孢他啶、環(huán)丙沙星、慶大霉素、紅霉素、妥布霉素、氯霉素、強力霉素、芐星青霉素敏感。結(jié)論首次發(fā)現(xiàn)巴爾通體菌株對利福平高度耐藥,需要進(jìn)一步了解其耐藥機(jī)制,減少不合理用藥,預(yù)防利福平耐藥在人分離株中發(fā)生。
[Abstract]:OBJECTIVE To investigate the biochemical characteristics and drug susceptibility of the monkey strain of Bartonella quinquefasciatus, and to lay a foundation for further study on the drug resistance mechanism of Bartonella quinquefasciatus.Methods The biochemical characteristics of one ATCC reference strain and 10 monkey isolates of Bartonella quinquefasciatus were detected by E-test. Results H15SC was highly resistant to rifampicin (MIC256), other strains were susceptible; H98SC was resistant to clindamycin, other strains were susceptible; the other 10 strains were susceptible to amikacin and polymyxin except S13; all strains were susceptible to azithromycin, ceftazidime, ciprofloxacin, gentamicin, erythromycin, tobramycin, chloramphenicol, doxycycline, etc. Conclusion Bartonella isolates are highly resistant to rifampicin for the first time, so it is necessary to understand the mechanism of rifampicin resistance, reduce irrational drug use and prevent rifampicin resistance in human isolates.
【作者單位】： 中國疾病預(yù)防控制中心傳染病預(yù)防控制所傳染病預(yù)防控制國家重點實驗室感染性疾病診治協(xié)同創(chuàng)新中心世界衛(wèi)生組織媒介生物監(jiān)測與管理合作中心;泰山醫(yī)學(xué)院;北京市豐臺區(qū)疾病預(yù)防控制中心;
【基金】：國家自然科學(xué)基金(No.81141108)~~
【分類號】：R376

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