【摘要】：目的探討大鼠食管支架置入及術(shù)后食管良性增生性狹窄模型構(gòu)建的可行性和安全性。方法實(shí)驗(yàn)使用定制的自膨式金屬直筒支架(直徑5 mm,長(zhǎng)15 mm),其中部?jī)蓚?cè)各有一外突倒刺用作固定,防止滑脫移位。12只健康Sprague-Dawley大鼠隨機(jī)分成A組(空白對(duì)照組)和B組(支架置入組),每組6只;B組大鼠食管內(nèi)置入支架,分別于置入即刻、1周、4周作食管造影。4周后處死所有大鼠,取A組正常食管組織及B組支架部位食管組織作大體形態(tài)、光鏡等病理學(xué)分析。結(jié)果 B組食管內(nèi)支架置入均獲成功,術(shù)后即刻、1周、4周復(fù)查造影均未發(fā)現(xiàn)食管內(nèi)支架移位,手術(shù)及隨訪期間無(wú)嚴(yán)重并發(fā)癥發(fā)生。與A組相比,4周后B組復(fù)查造影顯示支架段食管增生導(dǎo)致食管狹窄,取出支架部位食管段肉眼見管腔明顯狹窄,光鏡下呈典型良性增生樣表現(xiàn)。結(jié)論采用大鼠構(gòu)建食管支架置入后再狹窄模型安全、可行,帶倒刺食管支架能夠明顯降低支架置入后移位發(fā)生率。
[Abstract]:Objective to investigate the feasibility and safety of esophageal stent implantation and postoperative benign esophageal hyperplastic stenosis in rats. Methods the self-expandable metal straight tube scaffold (5 mm in diameter and 15 mm), long in length) was used as the fixator with a protruding barb on each side of the middle part of the scaffold. Twelve healthy Sprague-Dawley rats were randomly divided into two groups: group A (blank control group) and group B (stent implantation group). All the rats were killed at 1 week and 4 weeks after esophagography respectively. The normal esophageal tissues in group A and the esophageal tissues in group B were taken for general morphology, light microscopy and other pathological analysis. Results esophageal stents were successfully implanted in group B, and no intraesophageal stent displacement was found immediately after 1 week and 4 weeks after operation, and no serious complications occurred during operation and follow-up. Compared with group A, 4 weeks later, group B showed esophageal stricture caused by esophageal hyperplasia in stent segment, and obvious stenosis of esophageal lumen was observed in the removal of stents, and typical benign hyperplasia was observed under light microscope. Conclusion it is safe and feasible to construct a restenosis model with esophageal stent implantation in rats. Esophageal stents with inverted stents can significantly reduce the incidence of transposition after stent implantation.
【作者單位】： 南京醫(yī)科大學(xué)第一附屬醫(yī)院介入放射科;
【分類號(hào)】：R-332;R571

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