【摘要】：目的基于逆向工程技術(shù)建立正常主動(dòng)脈和胸主動(dòng)脈瘤的個(gè)體化模型，應(yīng)用計(jì)算流體動(dòng)力學(xué)方法進(jìn)行脈動(dòng)血流數(shù)值模擬，探討主動(dòng)脈夾層的病因機(jī)制以及胸主動(dòng)脈瘤生長、破裂的機(jī)制。方法用MIMICS軟件讀取DICOM格式CTA數(shù)據(jù)，重建三維主動(dòng)脈模型，應(yīng)用有限體積法Fluent軟件進(jìn)行血流數(shù)值模擬，分析與胸主動(dòng)脈夾層形成及動(dòng)脈瘤生長、破裂相關(guān)的血流動(dòng)力學(xué)參數(shù)。 結(jié)果 （1）正常胸主動(dòng)脈數(shù)值模擬血流動(dòng)力學(xué)參數(shù)。 （2）胸主動(dòng)脈瘤數(shù)值模擬血流動(dòng)力學(xué)參數(shù)。結(jié)論 （1）基于高分辨率CTA數(shù)據(jù)可以重建解剖精確的三維血管模型，計(jì)算機(jī)數(shù)值模擬是研究胸主動(dòng)脈血流動(dòng)力學(xué)參數(shù)的有效手段。 （2）脈動(dòng)流條件下，胸主動(dòng)脈血流流場復(fù)雜，，胸主動(dòng)脈幾何形態(tài)對血流方式有較大影響，湍流不利于血液流動(dòng)。 （3）胸主動(dòng)脈壓力的波動(dòng)與主動(dòng)脈夾層的形成有關(guān)。 （4）低壁切應(yīng)力與胸主動(dòng)脈粥樣硬化及斑塊形成有關(guān)。 （5）低壁切應(yīng)力與胸主動(dòng)脈瘤的生長、破裂有關(guān)。 （6）低壁切應(yīng)力與胸主動(dòng)脈瘤體內(nèi)附壁血栓形成有關(guān)。
[Abstract]:Objective to establish individual models of normal and thoracic aortic aneurysms based on reverse engineering, and to investigate the etiological mechanism of aortic dissection and the growth of thoracic aortic aneurysms by using computational fluid dynamics (CFD). The mechanism of rupture. Methods MIMICS software was used to read the CTA data of DICOM format, and 3D aortic model was reconstructed. The hemodynamic parameters related to the formation of thoracic aortic dissection, the growth and rupture of aneurysms were analyzed by using the finite volume method Fluent software. Results (1) normal thoracic aorta were numerically simulated with hemodynamic parameters, (2) thoracic aortic aneurysms were numerically simulated with hemodynamic parameters. Conclusion (1) Three-dimensional vascular model can be reconstructed by high-resolution CTA data. Computer numerical simulation is an effective method to study the hemodynamic parameters of thoracic aorta. (2) under pulsating flow conditions, The flow field of thoracic aorta is complex and the geometry of thoracic aorta has great influence on the blood flow pattern. (3) the fluctuation of thoracic aortic pressure is related to the formation of aortic dissection. (4) low wall shear stress is related to the formation of atherosclerosis and plaque in thoracic aorta. Shear stress and the growth of thoracic aortic aneurysms, (6) low wall shear stress is associated with mural thrombosis in thoracic aortic aneurysms.
【學(xué)位授予單位】：中國人民解放軍醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R331

【參考文獻(xiàn)】

相關(guān)期刊論文 前4條

1 林亞華;景在平;趙志清;梅志軍;馮翔;馮睿;陸清聲;;人胸主動(dòng)脈血液脈動(dòng)流的三維數(shù)值分析[J];第二軍醫(yī)大學(xué)學(xué)報(bào);2006年08期

2 湯敬東,景在平,熊江,趙新,黃晟,高嵩,賈寶成,趙新,施萍;波動(dòng)性高血壓與中膜板層變化的動(dòng)物實(shí)驗(yàn)[J];中華實(shí)驗(yàn)外科雜志;2004年05期

3 邱霖,岑人經(jīng);有錐度角的主動(dòng)脈弓血液脈動(dòng)流數(shù)值分析[J];醫(yī)用生物力學(xué);2004年02期

4 劉有軍,喬愛科,黃偉,曾衍鈞;血流動(dòng)力學(xué)數(shù)值模擬與動(dòng)脈粥樣硬化研究進(jìn)展[J];力學(xué)進(jìn)展;2002年03期

相關(guān)博士學(xué)位論文 前1條

1 林亞華;胸主動(dòng)脈夾層的血液動(dòng)力學(xué)研究[D];第二軍醫(yī)大學(xué);2006年

本文編號：2141094