本文選題：心房 + 顫動(dòng)�。� 參考：《南京大學(xué)》2012年碩士論文

【摘要】：背景——房顫(Atrial fibrillation, AF),被認(rèn)為有著復(fù)雜的起因和維持機(jī)制。對(duì)于復(fù)率后的竇性心律信號(hào),如何評(píng)估長(zhǎng)時(shí)間維持房顫的可能性未見有過報(bào)道。論文的目的是通過分析快速犬類房顫模型中階梯狀乙酰膽堿(Acetylcholine, ACh)劑量下的竇性心律電信號(hào),探索研究心房易顫性(誘發(fā)出房顫的可能性)的方法。 方法和結(jié)果——實(shí)驗(yàn)建立了8只犬快速房顫模型,在動(dòng)物的左右心房、左右心房后部及4條肺靜脈根部放置了128路電極構(gòu)成的電標(biāo)記系統(tǒng)。實(shí)驗(yàn)中注入階梯式濃度的ACh,得到對(duì)應(yīng)不同ACh濃度的竇性心電。通過對(duì)犬采集CT斷層圖片,利用GVF-Snake模型采用基于輪廓線的三維重建技術(shù)建立了動(dòng)物體的三維模型,并通過反向距離加權(quán)平均和Delaunay三角剖分的方法實(shí)現(xiàn)了模型的參數(shù)顯示。在右心房表面電極施力(?)bust刺激,記錄刺激出的房顫時(shí)間和次數(shù),通過房顫總維持時(shí)間來表征不同ACh濃度下房顫維持的可能性。并嘗試找到可以與房顫維持時(shí)間對(duì)應(yīng)的某種竇性心電的參數(shù)。根據(jù)相同步的概念,提出了心房工作在與竇房結(jié)同步的工作模式下的假設(shè),利用相位同步的方法,計(jì)算所有導(dǎo)聯(lián)對(duì)竇房結(jié)的竇性心電相位差矩陣香農(nóng)熵(SE),并發(fā)現(xiàn)SE對(duì)ACh劑量曲線與房顫總時(shí)間對(duì)ACh曲線相似。我們隨后也測(cè)試了信號(hào)頻率及導(dǎo)聯(lián)數(shù)目對(duì)SE曲線的影響。 結(jié)論——我們發(fā)現(xiàn)竇性心電相位差矩陣的香農(nóng)熵SE的升高意味著誘發(fā)出的房顫維持長(zhǎng)時(shí)間的可能性升高。為復(fù)律后通過竇性心電判斷房顫復(fù)發(fā)可能性提供了一種方法。
[Abstract]:Background-Atrial fibrillation (Atrial fibrillation, AF) is considered to have complex causes and maintenance mechanisms. How to evaluate the possibility of long-term maintenance of atrial fibrillation has not been reported for sinus rhythm signals after recovery. The purpose of this paper is to study the possibility of atrial fibrillation (AF) by analyzing the sinusoidal electrical signals at the dose of acetylcholine (ach) in a fast canine atrial fibrillation model. Methods and results: eight canine models of rapid atrial fibrillation were established. An electrical labeling system composed of 128 electrodes was placed in the left and right atrium, the posterior part of the left and right atrium and the root of 4 pulmonary veins. In the experiment, step by step concentration of ache was injected and sinus electrocardiogram corresponding to different ach concentration was obtained. By collecting CT images of dogs and using GVF-Snake model, the 3D models of animals and animals are established by using the three-dimensional reconstruction technique based on contour, and the parameter display of the model is realized by means of inverse distance weighted average and Delaunay triangulation. The time and times of atrial fibrillation induced by bust stimulation at right atrial surface electrode were recorded, and the possibility of atrial fibrillation maintenance under different ach concentrations was characterized by the total duration of atrial fibrillation. And try to find some sinus parameters corresponding to the duration of atrial fibrillation. Based on the concept of phase synchronization, the assumption that atrial work is in synchronous mode with sinus node is proposed, and the method of phase synchronization is used. The phase difference matrix Shannon entropy (SE) of sinus electrocardiogram for all leads to sinoatrial node was calculated, and it was found that the dose curve of SE to ach was similar to that of total time of atrial fibrillation. We also tested the influence of signal frequency and lead number on SE curve. Conclusion-We found that the increase of Shannon entropy SE of the phase difference matrix of sinus electrocardiogram means that the induced atrial fibrillation is more likely to last for a long time. It provides a method for judging the possibility of recurrence of atrial fibrillation by sinus electrocardiogram after cardioversion.
【學(xué)位授予單位】：南京大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R541.75;R-332

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 侯志強(qiáng),韓崇昭;基于力場(chǎng)分析的主動(dòng)輪廓模型[J];計(jì)算機(jī)學(xué)報(bào);2004年06期

2 邵毅;展慶波;童唐驥;陳穎;Martyn P NASH;;三維可視化顯示心外膜電生理參數(shù)的方法[J];科技導(dǎo)報(bào);2009年12期

，

本文編號(hào)：2107895