天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

益腎通癃膠囊對前列腺增生模型小鼠生殖激素水平的影響

發(fā)布時間:2018-07-07 17:17

  本文選題:益腎通癃膠囊 + 良性前列腺增生 ; 參考:《中華男科學雜志》2016年11期


【摘要】:目的:探討益腎通癃膠囊對良性前列腺增生(BPH)模型小鼠生殖激素水平的影響。方法:對SPF雄性小鼠皮下注射丙酸睪酮5mg/(kg·d),連續(xù)3周,待造模成功后分為6組:正常對照組,模型組,癃閉舒膠囊組,益腎通癃膠囊高、中、低劑量組,每組10只。益腎通癃膠囊高、中、低劑量組分別用1.2,0.6,0.3 g/kg益腎通癃膠囊混懸液灌胃,癃閉舒膠囊組用0.45 g/kg癃閉舒膠囊混懸液灌胃,正常對照組及模型組給予同體積蒸餾水。給藥8周后處死小鼠,稱取前列腺濕重并計算前列腺指數(shù)(PI),測量小鼠血清中睪酮(T)、雌二醇(E2)的水平、E2/T比值,光鏡下觀察小鼠前列腺組織的形態(tài)變化。結果:與模型組比較,益腎通癃膠囊中、高劑量組及癃閉舒膠囊組均可降低模型小鼠前列腺濕重、PI指數(shù)(P均0.01)。各組小鼠血清T、E2、E2/T水平:正常對照組:(1.73±0.02)ng/ml、(73.08±1.03)pg/ml、42.30±0.53;模型組:(3.86±0.02)ng/ml,(145.79±0.88)pg/ml,37.76±0.25;癃閉舒膠囊組:(2.47±0.02)ng/ml,(95.87±0.47)pg/ml,38.80±0.13;益腎通癃膠囊高劑量組:(2.75±0.03)ng/ml,(107.11±0.61)pg/ml,38.92±0.36;益腎通癃膠囊中劑量組:(2.77±0.02)ng/ml,(112.16±0.82)pg/ml,40.56±0.29;益腎通癃膠囊低劑量組:(2.91±0.03)ng/ml,(112.68±0.77)pg/ml,38.80±0.42,各組與模型組相比,差異均具有統(tǒng)計學意義(P0.05或P0.01)。結論:益腎通癃膠囊可能通過降低BPH模型小鼠血清T、E2,升高E2/T比值,揭示了益腎通癃膠囊治療BPH的機制。
[Abstract]:Objective: To investigate the effect of Yishen Tong Long capsule (Yishen Tong Long capsule) on the level of reproductive hormone in mice with benign prostatic hyperplasia (BPH). Methods: SPF male mice were subcutaneously injected with testosterone propionate 5mg/ (kg. D) for 3 weeks. After the model was successful, the model group was divided into 6 groups: normal control group, model group, yishanshu capsule group, Yishen Tong Long capsule high, medium and low dose group, 10 rats in each group. Yishen Tong Long capsule high, medium and low dose group were fed with 1.2,0.6,0.3 g/kg Yishen Tong Long capsule suspension, respectively, and long Shu Capsule group was fed with 0.45 g/kg long long closed capsule suspension. The normal control group and the model group were given the same volume of distilled water. After 8 weeks of administration, the mice were killed and the prostatic index (PI) was measured and the mice were measured, and the mice were measured. The level of serum testosterone (T), estradiol (E2), E2/T ratio, and the morphological changes of the prostate tissue in mice were observed under light microscope. Results: compared with the model group, the high dose group and the long closed capsule group could reduce the wet weight of the prostate in the model mice and the number of PI (P 0.01). The serum T, E2, E2/T level of the mice in each group: (1.7 3 + 0.02) ng/ml, (73.08 + 1.03) pg/ml, 42.30 + 0.53, model group: (3.86 + 0.02) ng/ml, (145.79 + 0.88) pg/ml, 37.76 + 0.25, (2.47 + 0.02) ng/ml, (2.47 + 0.53) ng/ml, high dose group of Yishen Tong Long capsule: ng/ml /ml, (112.16 + 0.82) pg/ml, 40.56 + 0.29, Yishen Tong Long capsule low dose group: (2.91 + 0.03) ng/ml, (112.68 + 0.77) pg/ml, 38.80 + 0.42, the difference was statistically significant compared with the model group (P0.05 or P0.01). Conclusion: Yishen Tong Long capsule may reduce the serum T, E2, and E2/T ratio of BPH model mice, and reveal Yishen Tong Long glue The mechanism of the cysts for the treatment of BPH.
【作者單位】: 湖南中醫(yī)藥大學第一附屬醫(yī)院中醫(yī)外科;湖南中醫(yī)藥大學研究生院;
【基金】:湖南中醫(yī)藥管理局重點科研項目(201510)~~
【分類號】:R277.5;R-332
,

本文編號:2105670

資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/xiyixuelunwen/2105670.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權申明:資料由用戶6cc92***提供,本站僅收錄摘要或目錄,作者需要刪除請E-mail郵箱bigeng88@qq.com
av在线免费观看一区二区三区| 午夜精品在线观看视频午夜| 人体偷拍一区二区三区| 一区二区三区日韩中文| 暴力三级a特黄在线观看| 亚洲熟女国产熟女二区三区| 亚洲三级视频在线观看免费| 国产成人国产精品国产三级| 欧美日韩无卡一区二区| 欧美野外在线刺激在线观看| 亚洲黄色在线观看免费高清| 日韩欧美在线看一卡一卡| 人妻一区二区三区多毛女| 女生更色还是男生更色| 91精品欧美综合在ⅹ| 日韩成人动作片在线观看| 亚洲综合香蕉在线视频| 日韩国产欧美中文字幕| 亚洲国产欧美久久精品| 国产精品欧美在线观看| 久热人妻中文字幕一区二区| 小草少妇视频免费看视频| 国产精品欧美一级免费| 日韩欧美一区二区不卡视频| 日韩欧美中文字幕人妻| 国产色一区二区三区精品视频 | 日韩人妻有码一区二区| 果冻传媒精选麻豆白晶晶| 国产精品视频一级香蕉| 熟女高潮一区二区三区| 亚洲一区二区三区精选| 国产免费一区二区三区不卡| 人妻精品一区二区三区视频免精| 日韩性生活视频免费在线观看 | 欧美日韩国产午夜福利| 激情偷拍一区二区三区视频 | 麻豆印象传媒在线观看| 欧洲自拍偷拍一区二区| 人妻亚洲一区二区三区| 五月综合婷婷在线伊人| 中文字幕人妻一区二区免费|