本文選題：太赫茲時(shí)域光譜 + 比較研究��； 參考：《天津大學(xué)》2012年碩士論文

【摘要】：近年來(lái)太赫茲時(shí)域光譜技術(shù)作為自然科學(xué)領(lǐng)域異軍突起的一種新興技術(shù)越來(lái)越受到人們的關(guān)注，尤其是在生物醫(yī)學(xué)領(lǐng)域，科學(xué)工作者寄希望于該技術(shù)能夠更好的在腫瘤診斷、燒傷治療等領(lǐng)域發(fā)揮作用，造福人類。 本課題的目的在于運(yùn)用太赫茲時(shí)域光譜技術(shù)對(duì)生物醫(yī)學(xué)領(lǐng)域中常見(jiàn)的惡性癌變組織進(jìn)行診斷研究，在實(shí)驗(yàn)技術(shù)和理論分析方面積累經(jīng)驗(yàn)，縮小與國(guó)外同類別研究的差距。比較研究主要體現(xiàn)在：實(shí)驗(yàn)方式分為透射式和反射式；實(shí)驗(yàn)對(duì)象分為石蠟封裝的基底細(xì)胞癌組織和新鮮癌變組織。 本課題總結(jié)了太赫茲技術(shù)在生物醫(yī)學(xué)領(lǐng)域的應(yīng)用，包括太赫茲輻射效應(yīng)、太赫茲光譜技術(shù)和太赫茲成像技術(shù)。在了解皮膚結(jié)構(gòu)和組成物質(zhì)的基礎(chǔ)上重點(diǎn)對(duì)組織中的水化作用展開了研究，引入了皮膚分層模型和Debye模型，，得到了不同狀態(tài)下水在太赫茲頻段的介電特性。通過(guò)透射式太赫茲時(shí)域光譜技術(shù)，運(yùn)用1.3THz下的吸收系數(shù)獲得了基底細(xì)胞癌樣品的圖像，并從病理學(xué)的角度給予解讀，獲得了癌變區(qū)域和健康區(qū)域的復(fù)介電常數(shù)。同時(shí)運(yùn)用MATLAB和LabVIEW混合編程設(shè)計(jì)了不同方法的成像界面。反射式太赫茲時(shí)域光譜技術(shù)的實(shí)驗(yàn)研究也取得了進(jìn)展。搭建了自行設(shè)計(jì)的光纖化的反射式實(shí)驗(yàn)系統(tǒng)，論證了系統(tǒng)搭建過(guò)程中透鏡及參數(shù)的選擇，光纖色散及補(bǔ)償問(wèn)題，系統(tǒng)的頻譜寬度為0.15～1.2THz，光斑直徑為3mm，滿足測(cè)量要求。同時(shí)對(duì)新鮮健康皮膚組織、脂肪瘤組織、基底細(xì)胞癌組織開展了研究，得到了區(qū)分度明顯的吸收系數(shù)譜線。在反射式光纖化系統(tǒng)搭建和實(shí)驗(yàn)方法技巧方面積累了經(jīng)驗(yàn)。使用統(tǒng)計(jì)學(xué)方法-判別分析實(shí)現(xiàn)了對(duì)癌變區(qū)域和健康區(qū)域正確的區(qū)別，實(shí)現(xiàn)了定量檢測(cè)，為將來(lái)太赫茲時(shí)域光譜技術(shù)用于醫(yī)學(xué)臨床奠定了基礎(chǔ)。
[Abstract]:In recent years, terahertz time-domain spectroscopy (THz), as an emerging technology in the field of natural science, has attracted more and more attention, especially in the field of biomedicine. Burn treatment and other fields play a role in the benefit of mankind. The purpose of this paper is to use THz time domain spectroscopy to diagnose malignant cancerous tissues in biomedical field, accumulate experience in experimental technology and theoretical analysis, and narrow the gap with the same kind of research abroad. The comparative studies are as follows: the experimental methods are transmissive and reflex, and the experimental objects are paraffin encapsulated basal cell carcinoma and fresh cancerous tissue. This paper summarizes the applications of terahertz technology in biomedical fields, including terahertz radiation effect, terahertz spectroscopy and terahertz imaging technology. Based on the understanding of skin structure and composition, the hydration in tissues was studied. Skin delamination model and Debye model were introduced, and the dielectric properties of water in different states at terahertz band were obtained. By using the transmission terahertz time-domain spectroscopy (THz), the image of basal cell carcinoma (BCC) samples was obtained by using the absorption coefficient under 1.3THz, and the complex permittivity of cancerous and healthy regions was obtained from the point of view of pathology. At the same time, the imaging interface of different methods is designed by mixed programming of MATLAB and LabVIEW. Progress has also been made in the experimental study of reflective terahertz time domain spectroscopy. A self-designed fiber-optic reflective experimental system is built, and the selection of lens and parameters, fiber dispersion and compensation are demonstrated. The spectrum width of the system is 0.151.2THZ, and the spot diameter is 3mm, which meets the measurement requirements. At the same time, fresh healthy skin tissue, lipoma tissue and basal cell carcinoma tissue were studied, and the distinct absorption coefficient lines were obtained. Experience has been accumulated in the construction of reflective fiber optic systems and the techniques of experimental methods. The use of statistical method-discriminant analysis to realize the correct distinction between cancerous and healthy regions, and to achieve quantitative detection, laid a foundation for the future use of terahertz time-domain spectroscopy in medical clinic.
【學(xué)位授予單位】：天津大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R312

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