本文選題：牙周炎 + 牙槽骨　； 參考：《口腔醫(yī)學(xué)研究》2017年11期

【摘要】：目的:研究牙周炎對(duì)大鼠根分叉區(qū)牙槽骨微結(jié)構(gòu)的影響。方法:3月齡健康未孕大鼠14只,采用絲線結(jié)扎大鼠左側(cè)上頜第一磨牙建立實(shí)驗(yàn)性牙周炎模型(實(shí)驗(yàn)組),右側(cè)作為對(duì)照組。分別于建模后4周及8周時(shí)處死大鼠,并測(cè)量上頜磨牙牙周探診深度、收集上頜骨標(biāo)本。采用Micro-CT分析大鼠上頜第一磨牙根中1/3區(qū)牙槽骨微結(jié)構(gòu)的改變。結(jié)果:4周及8周實(shí)驗(yàn)組牙周探針深度均高于對(duì)照組(P0.05).Micro-CT圖像分析發(fā)現(xiàn)對(duì)照組牙槽骨致密,主要由板狀骨小梁構(gòu)成;實(shí)驗(yàn)組牙槽骨變疏松,桿狀骨小梁較多。牙槽骨微結(jié)構(gòu)參數(shù)分析發(fā)現(xiàn)4周及8周實(shí)驗(yàn)組骨密度(BMD)、骨體積分?jǐn)?shù)(BV/TV)及骨小梁寬度(Tb.Th.)均較對(duì)照組降低(P0.05),且8周實(shí)驗(yàn)組BMD、BV/TV、Tb.Th.較4周組降低(P0.05)。8周實(shí)驗(yàn)組骨小梁數(shù)目(Tb.N.)及骨髓腔寬度(Tb.Sp.)較對(duì)照組及4周實(shí)驗(yàn)組均增加(0.05)。結(jié)論:牙周炎可導(dǎo)致大鼠根分叉區(qū)牙槽骨丟失、骨小梁微結(jié)構(gòu)破壞,且這種破壞隨著時(shí)間延長(zhǎng)不斷加劇。
[Abstract]:Objective: to study the effect of periodontitis on alveolar bone microstructure in rat root bifurcation. Methods the experimental periodontitis model was established by ligating the left maxillary first molar of 14 healthy non-pregnant rats at the age of 3 months (experimental group, right side as control group). The rats were killed at 4 weeks and 8 weeks after modeling, and the periodontal probing depth of maxillary molars was measured, and maxillary bone specimens were collected. The microstructures of alveolar bone in 1 / 3 region of maxillary first molar were analyzed by Micro-CT. Results the depth of periodontal probe in the experimental group was higher than that in the control group at 4 and 8 weeks. Micro-CT images showed that the alveolar bone in the control group was dense, mainly composed of trabeculae, and the alveolar bone in the experimental group became loose, and the trabeculae of rod-shaped bone were more than those in the control group. Analysis of microstructural parameters of alveolar bone revealed that BMD, BV / TVV and trabecular width of the experimental group were observed at 4 and 8 weeks. Compared with the control group, BMDV / TVV / Tb. Th. were significantly lower in the experimental group than in the control group (P < 0.05), and BMDV / TVV / Tb. Th. Compared with the 4th week group, the number of trabecular bone in the experimental group was decreased by P0.05.8 weeks and the number of trabeculae in the experimental group was Tb.N.) And the width of medullary cavity Tb.Sp. Compared with the control group and the experimental group at 4 weeks, the increase of 0. 05%. Conclusion: periodontitis can lead to the loss of alveolar bone and the destruction of bone trabeculae in the forked area of rats.
【作者單位】： 蘭州市口腔醫(yī)院牙周黏膜科;上海交通大學(xué)醫(yī)學(xué)院附屬第九人民醫(yī)院牙周病科;上海交通大學(xué)醫(yī)學(xué)院附屬第九人民醫(yī)院口腔修復(fù)科 上海市口腔醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室;
【基金】：上海高校高峰高原學(xué)科建設(shè)項(xiàng)目(編號(hào):20152523) 蘭州口腔臨床醫(yī)學(xué)中心(2014)
【分類號(hào)】：R-332;R781.42

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 ;某些因素對(duì)大鼠胃肌電的影響[J];基礎(chǔ)醫(yī)學(xué)與臨床;2001年S1期

2 李淑云;簡(jiǎn)易大鼠灌胃器的制作[J];錦州醫(yī)學(xué)院學(xué)報(bào);2001年04期

3 孫同柱,付小兵,翁立新,梁雪梅,陳偉;介紹一種簡(jiǎn)易的大鼠保定方法[J];上海實(shí)驗(yàn)動(dòng)物科學(xué);2004年01期

4 周劍鋒,李娜,袁發(fā)煥,張耀全;腎間質(zhì)纖維化模型建立中大鼠行為改變的研究[J];中國(guó)行為醫(yī)學(xué)科學(xué);2005年04期

5 符路娣;蔡海云;;介紹一種簡(jiǎn)便的大鼠灌胃方法[J];中獸醫(yī)學(xué)雜志;2006年03期

6 劉海燕;;灌注固定大鼠的技術(shù)操作及常見問題[J];齊齊哈爾醫(yī)學(xué)院學(xué)報(bào);2006年11期

7 馮雪建;盧占軍;高登慧;;大鼠灌胃給藥方法的研究[J];實(shí)驗(yàn)動(dòng)物科學(xué)與管理;2006年04期

8 梁秀蘭;阮祥燕;蔣輝;王迎;;SD大鼠絕經(jīng)模型建立的研究[J];醫(yī)學(xué)綜述;2010年09期

9 楊光瑜;周繼紅;尹志勇;張岫竹;張良;劉大維;;低頻共振對(duì)大鼠生理功能影響研究[J];醫(yī)用生物力學(xué);2011年02期

10 郭恒怡,劉探娥,曹青,孫瑛,蔡英年,鄧希賢,陳華粹;缺氧敏感性不同的兩種大鼠心、肺組織腎上腺素類受體的比較[J];生理科學(xué);1986年05期

相關(guān)會(huì)議論文 前10條

1 孟越;郝松;李俊青;楊德鴻;;幾種模擬肽在PTH信號(hào)轉(zhuǎn)導(dǎo)途徑中的作用探究[A];中華醫(yī)學(xué)會(huì)第七次全國(guó)骨質(zhì)疏松和骨礦鹽疾病學(xué)術(shù)會(huì)議論文匯編[C];2013年

2 孟越;郝松;李俊青;楊德鴻;;PTH(1-28)在非PLC依賴PKC信號(hào)轉(zhuǎn)導(dǎo)途徑中的作用初探[A];中華醫(yī)學(xué)會(huì)第七次全國(guó)骨質(zhì)疏松和骨礦鹽疾病學(xué)術(shù)會(huì)議論文匯編[C];2013年

3 櫖蒲生;王日宏;杝灄生;，

本文編號(hào)：1832090