本文選題：應(yīng)激 + 生理指標　； 參考：《軍事醫(yī)學(xué)》2017年02期

【摘要】：隨著社會競爭的日益激烈,工作和生活節(jié)奏加快,人們所承受的壓力和挑戰(zhàn)越來越多,暴露于日常生活應(yīng)激的頻率和強度也越來越大。持續(xù)、過強的應(yīng)激暴露能破壞人體的生物學(xué)保護機制,并產(chǎn)生一系列生理、神經(jīng)內(nèi)分泌、神經(jīng)生化、免疫功能及心理行為等方面的變化,最終引發(fā)一系列危害身心健康的疾病。鑒于應(yīng)激已成為多種慢性疾病的重要病因或誘因,對應(yīng)激生理指標特別是反映應(yīng)激水平的客觀檢測指標的應(yīng)用研究,將為應(yīng)激相關(guān)疾病的防治提供依據(jù)。文獻報道有多種應(yīng)激生理指標,如皮質(zhì)醇、α-淀粉酶、兒茶酚胺、熱休克蛋白、促炎細胞因子等,該文針對應(yīng)激反應(yīng)最主要的兩條通路:下丘腦-垂體-腎上腺(HPA)軸和交感通路,將代表性的皮質(zhì)醇和α-淀粉酶作為應(yīng)激生理指標作一綜述。
[Abstract]:With the increasingly fierce competition in society, the pace of work and life accelerates, people are subjected to more and more pressures and challenges, and the frequency and intensity of exposure to daily life stress is also increasing. Continuous and excessive stress exposure can destroy the biological protection mechanism of human body and produce a series of physiological, neuroendocrine, neurobiochemistry, immune function and psychological behavior changes, and finally lead to a series of diseases harmful to physical and mental health. In view of the fact that stress has become an important cause or inducement of many chronic diseases, the study on the application of stress physiological indicators, especially the objective indicators reflecting the stress level, will provide a basis for the prevention and treatment of stress-related diseases. There are many physiological indexes of stress, such as cortisol, 偽 -amylase, catecholamine, heat shock protein, pro-inflammatory cytokine, etc. In this paper, there are two main pathways in stress response: hypothalamus-pituitary-adrenal (HPA) axis and sympathetic pathway. The typical cortisol and 偽-amylase were reviewed as stress physiological indexes.
【作者單位】： 第二軍醫(yī)大學(xué)心理與精神衛(wèi)生學(xué)系精神病學(xué)教研室;
【基金】：國家重大科學(xué)儀器設(shè)備開發(fā)專項(2013YQ19046708) 國家自然科學(xué)基金資助項目(81571169) 軍隊十二五重點資助項目(BWS14J021)
【分類號】：R363

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