本文選題：游泳運(yùn)動(dòng) + D-半乳糖　； 參考：《中國(guó)運(yùn)動(dòng)醫(yī)學(xué)雜志》2016年01期

【摘要】：目的:探討游泳運(yùn)動(dòng)對(duì)D-半乳糖所致衰老小鼠學(xué)習(xí)記憶和膽堿能系統(tǒng)功能的影響。方法:50只昆明種小鼠隨機(jī)分成5組:對(duì)照組、模型組、15 min/天游泳組、30 min/天游泳組、45 min/天游泳組。除對(duì)照組外,所有小鼠連續(xù)8周皮下注射D-半乳糖復(fù)制衰老模型。運(yùn)動(dòng)組小鼠從第5周開始運(yùn)動(dòng),連續(xù)4周。Morris水迷宮實(shí)驗(yàn)評(píng)價(jià)小鼠空間學(xué)習(xí)記憶能力。行為測(cè)試結(jié)束后,檢測(cè)小鼠腦組織丙二醛(MDA)含量和超氧化物歧化酶(SOD)、谷胱甘肽過氧化物酶(GSH-PX)活性及皮層和海馬組織中乙酰膽堿酯酶(ACh E)和膽堿乙�；D(zhuǎn)移酶(Ch AT)的活性。結(jié)果:水迷宮實(shí)驗(yàn)結(jié)果顯示:15 min/天和30 min/天游泳組逃避潛伏期顯著短于模型組,目標(biāo)象限搜索時(shí)間百分比、通過目標(biāo)區(qū)域次數(shù)均顯著多于模型組。酶活性檢測(cè)結(jié)果顯示:15min/天游泳組小鼠腦組織SOD顯著高于模型組,GSH-Px活性高于模型組但無(wú)顯著性,MDA含量顯著低于模型組;30 min/天游泳組小鼠腦組織SOD和GSH-Px活性均顯著高于模型組、MDA含量顯著低于模型組;15 min/天和30 min/天游泳組皮層和海馬組織中ACh E、Ch AT活性均顯著高于模型組。結(jié)論:15 min/天游泳運(yùn)動(dòng)和30 min/天游泳運(yùn)動(dòng)均能提高衰老模型小鼠的空間學(xué)習(xí)記憶能力,其中以30 min/天游泳運(yùn)動(dòng)的效果最好,其機(jī)制可能與其提高腦組織抗氧化和清除自由基能力,增強(qiáng)中樞膽堿能神經(jīng)系統(tǒng)功能有關(guān)。
[Abstract]:Aim: to investigate the effects of swimming on learning and memory and cholinergic system function in aging mice induced by D-galactose. Methods 50 Kunming mice were randomly divided into 5 groups: control group, model group, 30 min/ day swimming group, 30 min/ day swimming group, 45 min/ day swimming group. All the mice except the control group were subcutaneously injected with D-galactose for 8 weeks to make aging model. The exercise group began to exercise at the 5th week and the spatial learning and memory ability was evaluated by Morris water maze test for 4 weeks. After the behavior test, the contents of malondialdehyde (MDA), the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and the activities of acetylcholinesterase (ach) and choline acetyltransferase (Chat) in cortex and hippocampus were measured. Results: the results of water maze test showed that the escape latency of swimming group on 15 min/ and 30 min/ days was significantly shorter than that of model group, the percentage of target quadrant search time and the number of times of passing through target area were significantly higher than that of model group. The results of enzyme activity test showed that the activity of SOD in brain tissue of mice in 15 min / day swimming group was significantly higher than that in model group, but the content of SOD and GSH-Px in brain tissue of mice in 30 min/ day swimming group was significantly lower than that in model group 30 min/ day swimming group, but the activity of SOD and GSH-Px in brain tissue of model group was significantly higher than that of model group. The content of MDA in the model group was significantly lower than that in the model group on 15 min/ and 30 min/ days, and the activity of ACh Etchat in the cortex and hippocampus of the swimming group was significantly higher than that of the model group. Conclusion the spatial learning and memory ability of aging model mice can be improved by swimming on 15 min/ day and 30 min/ day swimming exercise, and 30 min/ day swimming exercise is the best. The mechanism may be related to the ability of antioxidant and free radical scavenging in brain tissue. Enhancing the function of central cholinergic nervous system.
【作者單位】： 濱州醫(yī)學(xué)院;
【分類號(hào)】：R338

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