本文選題：動物脫毛 + 組織病理變化　； 參考：《中藥藥理與臨床》2017年04期

【摘要】：目的:系統(tǒng)比較4種脫毛方法對小鼠毛發(fā)再生及毛發(fā)周期的影響。方法:分別用脫毛膏、硫化鈉、松香/石蠟及丙酸睪丸酮建立小鼠脫毛模型,觀察小鼠背部毛發(fā)脫毛狀況及新生毛發(fā)生長情況,并通過HE染色切片來綜合分析四種脫毛方法對毛囊形態(tài)、毛囊數(shù)量等影響。結(jié)果:脫毛膏法、硫化鈉法、松香/石蠟和丙酸睪丸酮法脫毛時間依次為(90±10)s,(150±30)s,(119.36±26.42)s和4周。脫毛外觀評定等級為優(yōu)的比例依次為91.37%,25.00%,50.00%,83.33%。組織病理觀察發(fā)現(xiàn)該4種方法炎性反應(yīng)均較輕,毛發(fā)再生速度以硫化鈉法最快,其次依次為脫毛膏、松香/石蠟、丙酸睪丸酮。結(jié)論:松香/石蠟適合于實驗周期較長的實驗、丙酸睪丸酮法適用于探究雄激素脫發(fā)的動物模型、脫毛膏法適用于微生物學(xué)及微生態(tài)學(xué)實驗中快速去除被毛暴露皮膚顯示血管便于采血及美容脫毛、硫化鈉法適用于一次性脫毛。
[Abstract]:Objective: to compare the effects of four methods of hair removal on hair regeneration and hair cycle in mice. Methods: the model of hair removal in mice was established with depilation ointment, sodium sulphide, rosin / paraffin and testosterone propionate, respectively. The condition of hair loss and the growth of newborn hair were observed. The effects of four depilation methods on hair follicle morphology and hair follicle number were analyzed by HE staining. Results: the depilation time of rosin / paraffin and testosterone propionate was 119.36 鹵26.42s and 4weeks, respectively, with the methods of hair removal ointment, sodium sulphide, rosin / paraffin and testosterone propionate, respectively. The proportion of the appraised grade of hair removal was 91.37 and 25.00, and the 50.00th part was 83.33. Histopathological observation showed that the inflammatory reaction of the four methods was mild, the rate of hair regeneration was the fastest by sodium sulfide method, followed by depilation ointment, rosin / paraffin wax and testosterone propionate. Conclusion: rosin / paraffin is suitable for long period experiment, and testosterone propionate method is suitable for exploring the animal model of androgen alopecia. The method of hair removal ointment can be used in microbiology and microecology experiments to quickly remove the hair and expose the skin to show that the blood vessels are easy to collect blood and to remove hair in beauty. Sodium sulfide method is suitable for one time hair removal.
【作者單位】： 成都中醫(yī)藥大學(xué);成都中醫(yī)藥大學(xué)附屬醫(yī)院;
【基金】：國家重大公共衛(wèi)生專項中醫(yī)學(xué)術(shù)流派傳承工作室建設(shè)項目(210049) 成都中醫(yī)藥大學(xué)2015年度科技發(fā)展基金(ZRQN1554)
【分類號】：R-332;R758.71

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