本文選題：成肌分化 + miRNA��； 參考：《中國生物工程雜志》2017年10期

【摘要】：成肌分化過程包括成肌細(xì)胞的增殖,然后分化為肌細(xì)胞,最后融合形成肌管;microRNA(miRNA)是一類在轉(zhuǎn)錄后水平調(diào)控基因表達(dá)的微小非編碼RNA,它通過靶向靶基因mRNA的3'UTR,抑制其翻譯或誘導(dǎo)其降解。已有研究表明,miRNA在成肌分化中起重要調(diào)控作用。根據(jù)表達(dá)方式的不同,分為肌肉特異表達(dá)的miRNA,有miR-1,miR-133,miR-206,miR-208,miR-499和miR-486;和非肌肉特異表達(dá)的miRNA,其中miR-27,miR-29,miR-128,miR-199a和miR-431在成肌分化過程中具有重要的調(diào)控功能。另外,闡述了幾個與miRNA相互作用從而調(diào)控成肌分化的lncRNA的功能。通過介紹兩類miRNA的靶基因及調(diào)控機制,闡述了最新的研究進(jìn)展。
[Abstract]:The process of myogenic differentiation involves the proliferation of myoblasts, which then differentiate into myocytes. Finally, myotube microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at post-transcriptional level. They inhibit their translation or induce their degradation by targeting the target gene mRNA's 3UTRs. It has been shown that miRNA plays an important role in myogenic differentiation. According to the different expression patterns, miRNAs were divided into muscle-specific miRNAs, including miR-1 miR-133nmiR-136 miR-206 miR-208miR-499 and miR-486, and non-muscle-specific miRNAs, in which miR-27 miR-29miR-29miR-128miR-199a and miR-431 had important regulatory functions in the process of myogenic differentiation. In addition, the functions of several lncRNA that interact with miRNA to regulate myogenic differentiation are described. Through introducing the target genes and regulatory mechanisms of two kinds of miRNA, the latest research progress was reviewed.
【作者單位】： 深圳大學(xué)生命與海洋科學(xué)學(xué)院;
【分類號】：R329.2
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本文編號：1786269