本文選題：走馬胎 + 佐劑性關節(jié)炎��； 參考：《中藥材》2017年05期

【摘要】：目的:觀察走馬胎對弗氏完全佐劑(CFA)誘導的佐劑性關節(jié)炎(AA)大鼠踝關節(jié)組織病理改變的影響。方法:采用CFA誘導大鼠AA模型,給予不同劑量走馬胎醇提物治療,進行關節(jié)腫脹個數和全身炎癥狀態(tài)評分以及足爪腫脹度測定,并觀察各組大鼠踝關節(jié)滑膜、軟骨、關節(jié)腔、周圍軟組織炎癥反應等組織病理改變情況,進行綜合評分。結果:與模型組比較,走馬胎能顯著減少AA模型大鼠關節(jié)腫脹個數,顯著降低模型動物全身炎癥評分,并顯著降低模型動物致炎側和繼發(fā)側足腫脹度(P0.05或P0.01);踝關節(jié)組織病理結果顯示,走馬胎能顯著抑制炎癥細胞的浸潤、滑膜增生及血管翳的形成,減輕軟骨及骨質損傷程度(P0.05或P0.01)。結論:走馬胎可顯著改善AA模型大鼠炎癥狀態(tài)和踝關節(jié)組織病變。
[Abstract]:Aim: to observe the effect of walking horse fetus on the pathological changes of ankle joint in rats with adjuvant arthritis (AAA) induced by CFA-induced complete adjuvant. Methods: the AA model was induced by CFA and treated with different doses of alcohol extract. The number of joint swelling, the score of systemic inflammation and the degree of paw swelling were measured. The synovial membrane, cartilage and articular cavity of ankle joint were observed in each group. The pathological changes of surrounding soft tissue such as inflammatory reaction were evaluated comprehensively. Results: compared with the model group, the number of joint swelling and the score of systemic inflammation were significantly decreased. The results of ankle histopathology showed that trochlea could significantly inhibit the infiltration of inflammatory cells, synovial hyperplasia and pannus formation, and alleviate the degree of cartilage and bone injury (P 0.05 or P 0.01). Conclusion: walking horse fetus can significantly improve the inflammatory state and ankle tissue lesion in AA model rats.
【作者單位】： 廣州中醫(yī)藥大學附屬中山醫(yī)院;
【基金】：廣東省中醫(yī)藥局科研基金(20171282) 中山市衛(wèi)生和計劃生育局醫(yī)學科研項目(2015J050)
【分類號】：R285.5;R-332

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