本文選題：KIRDL + 基因多態(tài)性　； 參考：《中國(guó)輸血雜志》2017年06期

【摘要】：目的分析漢族和蒙古族人群中KIR3DL1功能性等位基因的分布特征,探討不同民族和地理環(huán)境因素與KIR3DL1等位基因分布的關(guān)聯(lián)性。方法采用PCR-SSP法檢測(cè)云南地區(qū)360例漢族和108名蒙古族、內(nèi)蒙古地區(qū)48名蒙古族的KIR3DL1功能性等位基因,比較KIR3DL1功能基因亞型在不同民族和不同地區(qū)的分布特征。結(jié)果在云南的蒙古族和漢族之間,低表達(dá)等位基因KIR3DL1*007的攜帶率分別為45.54%和30.56%,KIR3DS1*013分別為3.70%和23.89%,分布有顯著差異;在云南和內(nèi)蒙古的蒙古族之間,無(wú)表達(dá)等位基因KIR3DL1*004的攜帶率分別為7.14%和37.50%,低表達(dá)等位基因KIR3DL1*005分別為2.86%和16.67%,功能等位基因分布有顯著差異;高表達(dá)等位基因型KIR3DL1*001和*016在云南和內(nèi)蒙古民族人群之間無(wú)明顯差異。結(jié)論 KIR3DL1基因功能亞型的分布在不同民族之間、以及同一民族不同地區(qū)之間的分布呈現(xiàn)明顯差異,KIR3DL1功能等位基因多態(tài)性分布特征與民族源流相關(guān),并可能與環(huán)境選擇因素相關(guān)。
[Abstract]:Objective to analyze the distribution characteristics of KIR3DL1 functional alleles in Han and Mongolian populations and to explore the relationship between KIR3DL1 alleles and ethnic and geographical factors.Methods the functional alleles of KIR3DL1 were detected by PCR-SSP method in 360 Han nationality and 108 Mongolian nationality in Yunnan and 48 Mongolian nationality in Inner Mongolia. The distribution characteristics of KIR3DL1 functional gene subtypes in different nationalities and different regions were compared.Results among Mongolian and Han nationality in Yunnan, the carrying rate of low expression allele KIR3DL1*007 was 45.54% and 30.56%, respectively, which were 3.70% and 23.89%, respectively, and there were significant differences between Mongolian nationality in Yunnan and Inner Mongolia.The carrying rate of non-expressed allelic KIR3DL1*004 was 7.14% and 37.50%, the low expression allele KIR3DL1*005 was 2.86% and 16.67%, respectively. The distribution of functional alleles was significantly different, and there was no significant difference between Yunnan and Inner Mongolia ethnic groups.Conclusion the distribution of functional subtypes of KIR3DL1 gene in different ethnic groups and different regions of the same ethnic group is obviously different. The distribution characteristics of KIR3DL1 functional allele polymorphism are related to the origin of ethnic origin and may be related to environmental selection factors.
【作者單位】： 昆明醫(yī)科大學(xué);中國(guó)醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院醫(yī)學(xué)生物學(xué)研究所;
【基金】：863國(guó)家高技術(shù)研究發(fā)展計(jì)劃(2012AA021802) 國(guó)家重點(diǎn)研發(fā)計(jì)劃生物安全領(lǐng)域關(guān)鍵技術(shù)研發(fā)重點(diǎn)專(zhuān)項(xiàng)(2016YFC1201700)
【分類(lèi)號(hào)】：R394
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本文編號(hào)：1735962