本文選題：促炎因子　切入點(diǎn)：緊密連接　出處：《生理科學(xué)進(jìn)展》2016年01期 　論文類型：期刊論文

【摘要】：緊密連接存在于所有上皮或內(nèi)皮細(xì)胞間連接的最頂端,是物質(zhì)經(jīng)過(guò)旁細(xì)胞途徑進(jìn)行物質(zhì)轉(zhuǎn)運(yùn)的結(jié)構(gòu)基礎(chǔ),具有"屏障"和"柵欄"的作用。在炎癥及免疫因素介導(dǎo)的多種疾病中,如炎癥性腸病、囊腫性纖維化、舍格倫綜合征和神經(jīng)系統(tǒng)炎癥等,患者血清及疾病累及的上皮或內(nèi)皮組織均出現(xiàn)多種促炎因子含量升高。促炎因子作用于相關(guān)的上皮或內(nèi)皮組織,通過(guò)影響緊密連接蛋白的表達(dá)、結(jié)構(gòu)和功能從而調(diào)控上皮或內(nèi)皮的旁細(xì)胞途徑通透性,是炎癥性疾病的一個(gè)重要的發(fā)病機(jī)制。本文重點(diǎn)綜述了促炎因子對(duì)腸道、呼吸道、唾液腺上皮以及腦微血管內(nèi)皮緊密連接的調(diào)控及其相關(guān)分子機(jī)制。
[Abstract]:Tight junctions exist at the top of the junctions between all epithelial or endothelial cells, and are the structural basis for substance transport through the paracellular pathway. It has the function of "barrier" and "palisade". In many diseases mediated by inflammation and immune factors, such as inflammatory bowel disease, cystic fibrosis, Shergren syndrome and inflammation of nervous system, etc. The serum of the patient and the epithelial or endothelial tissue affected by the disease have increased levels of various proinflammatory factors. The inflammatory stimulating factor acts on the related epithelium or endothelial tissue by affecting the expression of tight junction protein. The structure and function to regulate the permeability of the epithelial or endothelial paracellular pathway is an important mechanism of inflammatory diseases. This review focuses on the role of proinflammatory factors in intestinal and respiratory tract. Regulation of tight junctions of salivary gland epithelium and cerebral microvascular endothelium and its related molecular mechanisms.
【作者單位】： 北京大學(xué)口腔醫(yī)學(xué)院口腔頜面外科;北京大學(xué)醫(yī)學(xué)部生理學(xué)與病理生理學(xué)系;
【基金】：國(guó)家自然科學(xué)基金(81470756;81271161;81300893)資助課題
【分類號(hào)】：R363
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本文編號(hào)：1612543