本文關(guān)鍵詞：熟地平顫湯結(jié)合西醫(yī)常規(guī)療法治療帕金森病的臨床多中心隨機(jī)對(duì)照研究，，由筆耕文化傳播整理發(fā)布。

熟地平顫湯結(jié)合西醫(yī)常規(guī)療法治療帕金森病的臨床多中心隨機(jī)對(duì)照研究

Clinical multicenter randomized controlled study on treatment of Parkinson＇s disease with ＂Shudi Pingchan Decoction＂ and western medicine

[1] [2] [3] [4] [5] [6] [7] [8] [9]

YUAN Can-xing1 ZHI Hui-ping2 CHEN Shun-zhong3 CHEN Yun1 LI Jun1 SHEN Wei1HE Jian-cheng4 WANG Xiu-wei1 CHEN Yuan-tao31.Longhua Hospital Affiliated to Shanghai University of Tradi

[1]上海中醫(yī)藥大學(xué)附屬龍華醫(yī)院神經(jīng)內(nèi)科,上海200032; [2]上海中醫(yī)藥大學(xué)附屬曙光醫(yī)院神經(jīng)內(nèi)科,上海200021; [3]南京中醫(yī)藥大學(xué)附屬泰州市中醫(yī)院神經(jīng)內(nèi)科,江蘇泰州214523; [4]上海中醫(yī)藥大學(xué)基礎(chǔ)醫(yī)學(xué)院,上海201203

文章摘要：目的觀察具有滋補(bǔ)肝腎、通絡(luò)解毒功效中藥熟地平顫湯結(jié)合西醫(yī)常規(guī)療法治療帕金森病的臨床療效。方法采用多中心、隨機(jī)對(duì)照的方法 ,將120例病例隨機(jī)分為治療組和對(duì)照組各60例。對(duì)照組繼續(xù)原有西藥治療,治療組同時(shí)加用熟地平顫湯和蝎蜈膠囊,兩組療程均為3個(gè)月;觀察兩組臨床療效及治療后帕金森病統(tǒng)一評(píng)分量表（UPDRS）第二分量表（運(yùn)動(dòng)功能判斷）和第三分量表（病程中疾病發(fā)展程度的判斷）評(píng)分、改良的Hoehn＆Yahr分級(jí)、左旋多巴用量、＂開(kāi)關(guān)＂現(xiàn)象變化情況。結(jié)果治療組和對(duì)照組總有效率分別為43.33%、16.67%;組間療效比較,差異有統(tǒng)計(jì)學(xué)意義（P〈0.01）。治療組可明顯改善患者的運(yùn)動(dòng)癥狀,減少UP-DRS II（P〈0.05）和UPDRS III（P〈0.01）評(píng)分;對(duì)有開(kāi)關(guān)現(xiàn)象者可延長(zhǎng)開(kāi)期時(shí)間,減少關(guān)期時(shí)間（P〈0.05）,而且未見(jiàn)明顯毒副作用。結(jié)論熟地平顫湯結(jié)合西醫(yī)常規(guī)療法治療帕金森病具有增效減毒作用。

Abstr：Objective To observe the clinical efficacy of ＂Shudi Pingchan Decoction＂ and western medicine in the treatment of Parkinson＇s disease（PD）.Methods The multicentre,randomized controlled trial was used in this observation.Total 120 subjects were divided into control group and control group,60 cases in each group.Control group was continued to use levodopa while the treatment group was treated with levodopa and ＂Shudi Pingchan Decoction＂,with a course of 3 months.The UPDRS scale and switching time were measured.Results The total effective rate was 43.33% in the treatment group and 16.67% in the control group,with a striking difference between them（P0.01）.In the treatment group,the motor symptoms were obviously relieved,the scores of UPDRS Ⅱand UPDRS Ⅲ were reduced（P0.05,P0.01）;the time of turn-off was extended while the time of turn-on was reducedz（P0.05）.Conclusion ＂Shudi Pingchan Decoction＂ can help clinical effects and reduce adverse reactions.

文章關(guān)鍵詞：

Keyword：:Parkinson＇s disease integrative Chinese and western medicine ＂Shudi Pingchan Decoction＂

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課題項(xiàng)目：上海市科委重點(diǎn)項(xiàng)目（03-4119844）; 上海市教委發(fā)展基金項(xiàng)目（03CK19）; 國(guó)家自然科學(xué)基金項(xiàng)目（30472207）

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  本文關(guān)鍵詞：熟地平顫湯結(jié)合西醫(yī)常規(guī)療法治療帕金森病的臨床多中心隨機(jī)對(duì)照研究，由筆耕文化傳播整理發(fā)布。