本文關(guān)鍵詞：不同健脾方對(duì)脾虛證模型大鼠胃腸、甲狀腺及免疫功能的影響　出處：《中藥藥理與臨床》2016年03期 　論文類型：期刊論文

  更多相關(guān)文章： 四君子湯 補(bǔ)中益氣湯 參苓白術(shù)散 方證相關(guān) 胃腸 甲狀腺 免疫系統(tǒng)

【摘要】：目的:比較健脾-健脾滲濕-健脾升陽(yáng)三方對(duì)脾虛證模型大鼠消化系統(tǒng)、甲狀腺及免疫功能的影響。方法:雄性Wistar大鼠隨機(jī)分為正常對(duì)照組、脾虛模型組,采用過度疲勞+飲食失節(jié)的方法復(fù)制模型。造模2周后的大鼠隨機(jī)分為脾虛模型組、補(bǔ)中益氣湯組、四君子湯組、參苓白術(shù)散組。于造模第15天,給藥各組大鼠按4.05g/kg/d分別給予補(bǔ)中益氣湯、四君子湯、參苓白術(shù)湯灌胃;模型組和對(duì)照組給予等量蒸餾水,連續(xù)14d。實(shí)驗(yàn)期間觀察外觀大鼠外觀行為變化;測(cè)量體重1次/周;測(cè)定各組大鼠血中生長(zhǎng)抑素(SS)、胃動(dòng)素(MTL)、胃泌素(GAS)、白細(xì)胞介素-2(IL-2)、白細(xì)胞介素-6(IL-6)、D-木糖(D-xylose)、三碘甲狀腺原氨酸(T3)、甲狀腺素(T4)、β-內(nèi)啡肽(β-EP)。結(jié)果:與正常組相比,脾虛模型組大鼠外觀行為分值增加和體重下降、血中D-xylose和MTL、GAS、IL-2、IL-6、T3、T4、β-EP均降低,SS升高。與模型組相比,中藥方干預(yù)各組的大鼠體重、血中D-xylose、MTL、GAS、IL-2、IL-6、T3、T4、β-EP均升高,SS降低;其中補(bǔ)中益氣湯組血中IL-6、GAS、β-EP和參苓白術(shù)散組T3分別較其它二方組升高。結(jié)論:脾虛證模型大鼠存在胃腸、免疫及甲狀腺功能的異常,健脾、健脾滲濕、健脾升陽(yáng)三方對(duì)脾虛證模型大鼠的上述異常均有一定的改善作用,但在對(duì)甲狀腺、腦腸肽、免疫功能的調(diào)節(jié)作用上各有側(cè)重,補(bǔ)中益氣湯調(diào)節(jié)作用更為廣泛和明顯,參苓白術(shù)散次之,四君子湯則相對(duì)較弱。
[Abstract]:Objective: to compare the effects of invigorating spleen, invigorating spleen and infiltrating dampness and invigorating spleen and strengthening yang on digestive system, thyroid and immune function of rats with spleen deficiency syndrome. Methods: male Wistar rats were randomly divided into normal control group. The model group was divided into spleen deficiency model group, Buzhong Yiqi decoction group and Sijunzi decoction group. Shenling Baizhu powder group. On the 15th day, rats in each group were treated with Buzhong Yiqi decoction, Sijunzi decoction and Shenling Atractylodes decoction respectively according to 4.05 g / kg / d. The model group and the control group were given the same amount of distilled water for 14 days. Weight was measured once a week; Serum somatostatin (SS), motilin motilin (MTL), gastrin (GASA), interleukin-2 (IL-2) and interleukin-6 (IL-6) were measured. D-xyloseine, triiodothyronine (T3), thyroxine (T4), 尾 -endorphin (尾 -EPN). Results: compared with the normal group. In the spleen deficiency model group, the appearance behavior score increased and the body weight decreased, and the blood D-xylose and MTLGAS-IL-2IL-6 IL-6T _ 3 T _ 4, 尾 -EP decreased. Compared with the model group, compared with the model group, compared with the model group, compared with the model group, compared with the model group, the body weight of the rats treated with traditional Chinese medicine prescription increased, and the blood D-xylosetron IL-2IL-6T3T4 and 尾 -EP increased. SS decreased; The levels of IL-6GAS, 尾 -EP and T3 in BZYQD group were higher than those in other two groups, respectively. Conclusion: there are abnormal gastrointestinal, immune and thyroid function in spleen deficiency syndrome model rats. Invigorating spleen, invigorating spleen and infiltrating dampness, invigorating spleen and invigorating yang can ameliorate the above abnormalities in the model of spleen deficiency, but they have different emphasis on the regulation of thyroid gland, brain intestinal peptide and immune function. Buzhong Yiqi decoction has more extensive and obvious regulating effect, Shenling Atractylodes Powder is second, and Sijunzi decoction is relatively weak.
【作者單位】： 山東中醫(yī)藥高等�？茖W(xué)校;北京中醫(yī)藥大學(xué)重點(diǎn)方劑學(xué)學(xué)科;
【基金】：山東省2013-2014年度中醫(yī)藥科技發(fā)展計(jì)劃項(xiàng)目(2013-153)
【分類號(hào)】：R285.5;R-332
【正文快照】：

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