本文關鍵詞：Wnt和Notch通路在老齡個體骨髓間充質干細胞成骨中的調控　出處：《國際口腔醫(yī)學雜志》2017年04期 　論文類型：期刊論文

  更多相關文章： 信號通路 老齡 骨髓間充質干細胞 成骨

【摘要】：社會老齡化的加劇使老年個體骨損傷修復問題愈發(fā)突出,骨髓間充質干細胞(BMSC)是一種與骨代謝再生密切相關的骨髓細胞,其生物學特性(形態(tài)、表面特征、細胞周期、端粒酶以及細胞內活性氧簇水平等)以及增殖分化能力在生物體年齡影響下均發(fā)生了改變,成骨能力下降,影響了骨損傷的修復速度和質量。探索其中分子機制對改善老齡個體骨損傷康復有至關重要作用。參與調控的信號中,Wnt和Notch近年日益受到關注,二者對老齡BMSC成骨的調控有交互作用。老齡機體的氧化應激反應增加而生長因子生成減少,Wnt通路的轉錄因子β-catenin與叉頭家族轉錄因子的親和力增加,不再與T細胞因子和淋巴增強因子結合,故BMSC成骨減弱。同時老齡個體骨髓中BMSC數(shù)量減少,Notch抑制BMSC成骨來維持祖細胞池中BMSC的數(shù)量。Wnt和Notch之間還存在相互作用,如Notch過表達能夠削弱Wnt的影響等。此外,BMP-Smad轉錄因子活性下降,Hedgehog信號通路下調,亦影響著BMSC的成骨分化。本文對老齡個體BMSC生物學性能變化及其成骨分化過程中信號通路的調控作用進行綜述,為老齡個體骨相關性疾病的治療提供新思路。
[Abstract]:Aging society of the elderly individual bone injury repair problems become more prominent, bone marrow mesenchymal stem cells (BMSC) is a kind of bone metabolism is closely related with the regeneration of bone marrow cells and its biological characteristics (morphology, surface characteristics, cell cycle, telomerase and intracellular active oxygen cluster level) and proliferation changes in organisms under the influence of age, decreased bone ability, affect the speed and quality of bone injury repair. To explore the molecular mechanism of aging individual bone injury rehabilitation has a crucial role. The signal involved in the regulation of Wnt and Notch in recent years, increasing attention, the two have interaction effect on aging BMSC bone the regulation of oxidative stress. The increase of aging body growth factor decreased, increased transcription factor beta -catenin Wnt pathway and the forkhead family transcription factor T and cell affinity, not because The son and lymphoid enhancer factor binding, so BMSC bone decreased. While the number of BMSC aging individual bone marrow decreased, Notch inhibited BMSC osteoblast interaction between BMSC progenitor cell pool to maintain the number of.Wnt and Notch, such as overexpression of Notch can weaken the effect of Wnt. In addition, BMP-Smad decreased the activity of transcription factors Hedgehog signal pathway down, also affect the osteogenic differentiation of BMSC. This paper reviewed the biological properties of the aging individual BMSC change regulation and signaling pathway during the differentiation into bone, to provide new ideas for the treatment of aging individual bone related diseases.

【作者單位】： 口腔疾病研究國家重點實驗室國家口腔疾病臨床研究中心四川大學華西口腔醫(yī)院口腔頜面外科;
【基金】：國家自然科學基金(81270421,81571366)~~
【分類號】：R329.2
【正文快照】： 成骨細胞是參與骨生成的主要功能細胞,在骨的生長發(fā)育、新陳代謝及修復重建中發(fā)揮重要作用。成骨細胞來源于具有多向分化潛能的骨髓間充質干細胞(bone marrow derived mesenchymalstem cell,BMSC)。老齡個體骨骼質量下降,易發(fā)生骨損傷且修復較年輕個體困難,與BMSC的增齡性改變

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