本文關(guān)鍵詞：建立改良法兔VX2肝癌模型及肝動(dòng)脈聯(lián)合門靜脈插管的應(yīng)用　出處：《中國介入影像與治療學(xué)》2017年11期 　論文類型：期刊論文

  更多相關(guān)文章： 兔 VX肝癌 放射學(xué) 介入性 回歸分析

【摘要】：目的采用改良法建立兔VX2肝癌模型,探討經(jīng)肝動(dòng)脈聯(lián)合門靜脈插管技術(shù)的應(yīng)用并分析其影響因素。方法對60只健康新西蘭大白兔行改良開腹穿刺接種法移植肝癌,并行肝動(dòng)脈聯(lián)合門靜脈造影,根據(jù)術(shù)后是否發(fā)生短期死亡(術(shù)后7天內(nèi))分為存活組和死亡組,將可能導(dǎo)致實(shí)驗(yàn)兔死亡的因素進(jìn)行單因素分析,以有統(tǒng)計(jì)學(xué)意義的指標(biāo)為自變量,建立二分類Logistic回歸模型,分析導(dǎo)致實(shí)驗(yàn)兔死亡的獨(dú)立危險(xiǎn)因素。結(jié)果 60只實(shí)驗(yàn)兔均移植腫瘤成功,9只(9/60,15.00%)實(shí)驗(yàn)兔術(shù)后短期內(nèi)死亡,51只(51/60,85.00%)存活。單因素分析顯示兩組間體質(zhì)量2.5kg、術(shù)中追加麻醉、手術(shù)時(shí)間≥60min、切口長度≥5cm及總出血量≥25ml為相關(guān)影響因素(P均0.05)。Logistic回歸分析篩選出體質(zhì)量2.5kg、術(shù)中追加麻醉及出血量≥25ml為手術(shù)死亡的獨(dú)立危險(xiǎn)因素(P均0.01)。結(jié)論改良法兔VX2肝癌模型建立成功率較高;選擇體重較大的實(shí)驗(yàn)兔,同時(shí)加強(qiáng)手術(shù)技巧的訓(xùn)練,減少術(shù)中出血量和避免術(shù)中追加麻醉是進(jìn)行肝動(dòng)脈聯(lián)合門靜脈造影時(shí)降低實(shí)驗(yàn)兔死亡率的有效措施。
[Abstract]:Objective to establish rabbit VX2 liver cancer model by modified method to evaluate the hepatic artery and portal vein intubation technique and analyze its influencing factors. Method of transplant liver cancer in 60 healthy New Zealand white rabbits underwent laparotomy stabinoculation, hepatic artery combined with portal vein angiography, according to whether there was postoperative short-term mortality (7 days after operation inside) divided into survival group and death group, will likely lead to death factors of experimental rabbits were analyzed by univariate analysis, with statistically significant indicators as independent variables, the establishment of two classification Logistic regression model, analysis of risk factors causing death in rabbits. The results of 60 experimental rabbits were successfully transplanted tumor, 9 (9/60,15.00%) the rabbits died in a short period after the operation, only 51 (51/60,85.00%). Univariate analysis showed that the survival between the two groups in body weight 2.5kg, intraoperative additional anesthesia, operation time is larger than 60min, the length of incision was 5cm and the total amount of bleeding is more than 25ml related factors (P 0.05) analysis showed that the body weight of 2.5kg.Logistic regression, intraoperative additional anesthesia and bleeding more than 25ml independent risk factors of operative death (P 0.01). Conclusion the improved method of establishing rabbit VX2 liver cancer model has higher success rate; weight larger experimental rabbits, while strengthening the operation skills training, reducing the amount of intraoperative bleeding and avoid intraoperative additional anesthesia are effective measures to reduce the mortality of rabbit hepatic artery combined with portal vein angiography.

【作者單位】： 合肥市第三人民醫(yī)院影像中心;
【分類號】：R-332;R735.7
【正文快照】： 經(jīng)導(dǎo)管動(dòng)脈化療栓塞術(shù)(transcatheter　arterialchemoembolization,TACE)已成為中晚期原發(fā)性肝癌的標(biāo)準(zhǔn)治療方式[1],但單純TACE具有短期復(fù)發(fā),且復(fù)發(fā)率較高的缺點(diǎn),肝癌存在肝動(dòng)脈和門靜脈雙重血供是其復(fù)發(fā)的主要原因。研究[2-4]發(fā)現(xiàn)采用經(jīng)肝動(dòng)脈聯(lián)合門靜脈化療栓塞術(shù)治療中晚期

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