本文選題：綿羊 + 胃腸道線蟲(chóng)�。� 參考：《內(nèi)蒙古農(nóng)業(yè)大學(xué)》2017年碩士論文

【摘要】：近年來(lái),放牧綿羊胃腸道線蟲(chóng)對(duì)常用驅(qū)蟲(chóng)藥物的耐藥性與日俱增,給當(dāng)前畜牧業(yè)帶來(lái)的危害日益加劇,故此受到國(guó)內(nèi)外研究人員的廣泛關(guān)注。為了解放牧綿羊胃腸道線蟲(chóng)對(duì)常用驅(qū)蟲(chóng)藥物的耐藥性情況,本課題從以下幾個(gè)方面進(jìn)行了研究,結(jié)果如下:首先,使用高效液相色譜法和紫外分光光度法對(duì)市售的常用驅(qū)線蟲(chóng)藥物有效成分含量進(jìn)行了分析,評(píng)價(jià)了這些驅(qū)蟲(chóng)藥的質(zhì)量現(xiàn)狀。結(jié)果顯示:受檢測(cè)的21種常用驅(qū)線蟲(chóng)藥物中,合格品僅為23.8%。其中13種伊維菌素藥品(Ivermectin),合格率為23.1%;3種丙硫咪唑藥品(Albendazole),合格率為33.3%;5種氯氰碘柳胺鈉產(chǎn)品(Closantel sodium),合格率為20.0%�？傮w來(lái)看,市場(chǎng)上銷售的常用驅(qū)蟲(chóng)藥物合格率較低,質(zhì)量問(wèn)題非常嚴(yán)重。然后,從上述受檢藥品中,分別選擇有效成分檢測(cè)結(jié)果符合國(guó)家規(guī)定的三種藥物,通過(guò)糞便蟲(chóng)卵減少試驗(yàn),對(duì)呼盟、和林和薩拉齊地區(qū)的放牧綿羊感染的胃腸道線蟲(chóng)耐伊維菌素、丙硫咪唑以及氯氰碘柳胺鈉的情況進(jìn)行了初步調(diào)查,結(jié)果顯示:三個(gè)地區(qū)放牧綿羊胃腸道線蟲(chóng)均對(duì)伊維菌素和丙硫咪唑產(chǎn)生了不同程度的耐藥性,但是對(duì)氯氰碘柳胺鈉相對(duì)敏感。最后,為進(jìn)一步摸清放牧綿羊胃腸道線蟲(chóng)對(duì)伊維菌素和丙硫咪唑的耐藥情況,選用幼蟲(chóng)發(fā)育抑制試驗(yàn)和蟲(chóng)卵孵化幼蟲(chóng)試驗(yàn),對(duì)呼和浩特周邊地區(qū)某些綿羊的捻轉(zhuǎn)血矛線蟲(chóng)蟲(chóng)株進(jìn)行了耐藥性檢測(cè),結(jié)果顯示:被檢綿羊體內(nèi)的捻轉(zhuǎn)血矛線蟲(chóng)對(duì)于上述兩種藥物均有耐藥性。
[Abstract]:In recent years, the resistance of gastrointestinal nematode to common insect repellent drugs in grazing sheep is increasing, and the harm to animal husbandry is becoming more and more serious. Therefore, researchers at home and abroad have paid more and more attention to it. In order to understand the drug resistance of gastrointestinal nematode to common insect repellent drugs in grazing sheep, this paper studies the following aspects. The results are as follows: first, The content of active components of commonly used nematode drugs in the market was analyzed by HPLC and UV spectrophotometry, and the quality status of these insecticides was evaluated. The results showed that out of 21 commonly used nematode drugs tested, the qualified product was only 23.8. Among them, 13 ivermectinine drugs, the qualified rate was 23.1and the qualified rate was 33.3% and the qualified rate was 33.3%, and the qualified rate was 20.0% for Closantel sodium. Generally speaking, the qualified rate of commonly used insecticides sold on the market is low and the quality problem is very serious. Then, from the drugs examined above, the three kinds of drugs with the test results of the active components according to the regulations of the state were selected, and through the experiment of reducing fecal eggs, the test was carried out on the Huling League. A preliminary investigation of the resistance of gastrointestinal nematode infected by herding sheep to ivermectin, albendazole and sodium chloride iodothylamine was carried out in the areas of Helin and Sarazizi. The results showed that the gastrointestinal nematode of sheep in three areas were resistant to ivermectin and propimidazole to varying degrees, but sensitive to chlorocyanoiodothylamine sodium. Finally, in order to find out the resistance of gastrointestinal nematode to ivermectin and thiemizole in grazing sheep, larval development inhibition test and egg hatching larva test were selected. The drug resistance of some sheep strains in Hohhot area was tested. The results showed that the nematodes were resistant to the above two drugs in the tested sheep.
【學(xué)位授予單位】：內(nèi)蒙古農(nóng)業(yè)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：S858.26

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本文編號(hào)：1787799