天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

新型鉍基納米粒子用于放射治療增強

發(fā)布時間:2024-09-17 16:08
  放射療法是一種眾所周知的非侵入性治療方法,臨床中超過50%的癌癥患者采用放療手段。在理想的放射療法中,在腫瘤內(nèi)接受放療劑量,同時周圍的健康組織能夠免受輻射損傷。為了實現(xiàn)這一目標(biāo),可以通過與納米醫(yī)學(xué)相結(jié)合來改善放射療法。納米顆粒是一種非活性物理放射增敏劑,在腫瘤部位,納米顆粒周圍的沉積輻射劑量會局部增加。最近,具有診斷和治療功能的鉍基納米顆粒由于高原子序數(shù),低毒性和低成本作為放射治療和成像中的治療劑引起了廣泛的關(guān)注。在這項研究中,我們引入了新的多功能鉍基納米粒子,鉍鐵氧體(BFO)和氧化鉍釓(Bi Gd O3)納米粒子作為放射治療和成像的放射增敏劑。用溶膠-凝膠法合成了納米粒子。在合成納米顆粒并用PEG對其進行表面修飾后,通過CCK-8測定評估納米顆粒的生物相容性。通過體外(克隆形成實驗和CCk-8測試),體內(nèi)和凝膠劑量測定評估BFO和Bi Gd O3納米顆粒對放射治療中的輻射劑量增強的影響。使用具有的4T1乳腺癌BALB/c雌性荷瘤鼠進行體內(nèi)癌癥放射療。用于MR和CT圖像的體模研究的弛豫時間(R2)和CT值(HU)顯示出與納米顆粒和濃度的線性關(guān)...

【文章頁數(shù)】:120 頁

【學(xué)位級別】:博士

【文章目錄】:
摘要
Abstract
ABBREVIATION
CHAPTER 1 INTRODUCTION
    1.1 Background
    1.2 Problems and significances
    1.3 Radiation therapy
        1.3.1 External radiation therapy
        1.3.2 Internal Radiation Therapy-Brachytherapy
    1.4 Interaction of photon with matter
        1.4.1 Photoelectric effect
        1.4.2 Compton scattering
        1.4.3 Pair Production
    1.5 Nanoparticles in medicine
        1.5.1 Toxicity of nanoparticles
        1.5.2 Enhanced radiation dose by high atomic number nanoparticles
        1.5.3 Gold nanoparticles
        1.5.4 Bismuth nanoparticles
        1.5.5 Gadolinium nanoparticles
        1.5.6 Delivery of nanoparticles and drug in tumor
    1.6 Research contents in this study
CHAPTER 2 EXPERIMENTAL PROCEDUR
    2.1 Synthesis and characterization nanoparticles
        2.1.1 Materials
        2.1.2 Synthesis and characterization of BFO nanoparticles
        2.1.3 Synthesis and characterization of BiGd03 nanoparticles
    2.2 Gel dosimetry
    2.3 Biological experiment-(in vitro,in vivo)
        2.3.1 Cancer cell lines
        2.3.2 Cell culture
        2.3.3 The cytotoxicity of the nanoparticles
        2.3.4 Clonogenic assay
        2.3.5 In vitro radiotherapy (BFO nanoparticles)
    2.4 In vivo experiment (BiGdO3-PEG nanoparticles)
    2.5 MRI and CT imaging
    2.6 Inductive Heating Property
    2.7 Statistical analysis
CHAPTER 3 BISMUTH FERRITE NANOPARTICLES AS RADIOSENSITIZER
    3.1 Introduction
    3.2 Characterization of synthesized nanoparticles (BFO)
    3.3 In vitro experiment results
        3.3.1 Biocompatibility (BFO-NPs)
        3.3.2 In vitro-radiosensitization
    3.4 Gel results
    3.5 Imaging results
        3.5.1 T_2 MR imaging
        3.5.2 CT imaging
    3.6 Inductive heating property
    3.7 BFO nanoparticles-loaded brachytherapy spacer
    3.8 Discussion
    3.9 Conclusion
CHAPTER 4 BISMUTH GADOLINIUM OXIDE NANOPARTICLES ASRADIOSENSITIZER
    4.1 Introduction
    4.2 Characterization of synthesized nanoparticles (BiGdO_3)
    4.3 In vitro experiment-BiGdO_3 nanoparticles
        4.3.1 In vitro Biocompatibility
        4.3.2 In vitro radiosensitizing results-BiGdO_3
    4.4 Gel dosimetry results-BiGdO_3
    4.5 In vivo results-BiGdO_3
    4.6 Imaging-phantom and in vivo results-BiGdO_3
        4.6.1 MRI
        4.6.2 CT
    4.7 Discussion
    4.8 Conclusion
CHAPTER 5 BISMUTH- BASED NANOPARTICLES ASRADIOSENSITIZER
    5.1 Introduction
    5.2 Brachytherapy sources
    5.3 Monte Carlo simulations
        5.3.1 Calculation of TG-43 parameters
    5.4 Nanoparticles dose enhancement-simulation
        5.4.1 MCNP-Monte Carlo
        5.4.2 Analytical simulation
    5.5 Validation of radiation sources-MCNP
    5.6 Radiation Dose Enhancement-Results
        5.6.1 MCNP code
        5.6.2 Analytical method
    5.7 Discussion
    5.8 Conclusions
CHAPTER 6 CONCLUSION
    6.1 Thesis conclusion
    6.2 Study innovation
REFERENCES
ACKNOWLEDGMENT
RESUME /PUBLICATINS



本文編號:4005702

資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/shoufeilunwen/yxlbs/4005702.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶ecf86***提供,本站僅收錄摘要或目錄,作者需要刪除請E-mail郵箱bigeng88@qq.com
日本人妻免费一区二区三区| 91欧美激情在线视频| 欧美精品一区二区水蜜桃| 亚洲欧洲成人精品香蕉网| 麻豆印象传媒在线观看| 久七久精品视频黄色的| 东京热加勒比一区二区| 夜色福利久久精品福利| 久久精品亚洲精品国产欧美| 黄片三级免费在线观看| 成人午夜免费观看视频| 欧美亚洲综合另类色妞| 五月天综合网五月天综合网| 又大又紧又硬又湿又爽又猛| 日系韩系还是欧美久久| 九九热视频网在线观看| 日韩精品免费一区二区三区 | 粉嫩内射av一区二区| 亚洲av首页免费在线观看 | 国产激情国产精品久久源| 二区久久久国产av色| 欧美成人高清在线播放| 午夜资源在线观看免费高清| 精品欧美一区二区三久久| 国产精品免费视频久久| 日韩夫妻午夜性生活视频| 97人妻精品免费一区二区| 日本熟女中文字幕一区| 婷婷伊人综合中文字幕| 欧美日韩人妻中文一区二区| 欧美精品一区二区水蜜桃| 欧美av人人妻av人人爽蜜桃| 中文字幕有码视频熟女| 国产不卡的视频在线观看| 亚洲国产日韩欧美三级| 亚洲高清一区二区高清| 东北老熟妇全程露脸被内射| 国产成人精品国内自产拍| 草草视频精品在线观看| 免费高清欧美一区二区视频| 精品人妻一区二区四区|