天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

新型鉍基納米粒子用于放射治療增強

發(fā)布時間:2024-09-17 16:08
  放射療法是一種眾所周知的非侵入性治療方法,臨床中超過50%的癌癥患者采用放療手段。在理想的放射療法中,在腫瘤內(nèi)接受放療劑量,同時周圍的健康組織能夠免受輻射損傷。為了實現(xiàn)這一目標(biāo),可以通過與納米醫(yī)學(xué)相結(jié)合來改善放射療法。納米顆粒是一種非活性物理放射增敏劑,在腫瘤部位,納米顆粒周圍的沉積輻射劑量會局部增加。最近,具有診斷和治療功能的鉍基納米顆粒由于高原子序數(shù),低毒性和低成本作為放射治療和成像中的治療劑引起了廣泛的關(guān)注。在這項研究中,我們引入了新的多功能鉍基納米粒子,鉍鐵氧體(BFO)和氧化鉍釓(Bi Gd O3)納米粒子作為放射治療和成像的放射增敏劑。用溶膠-凝膠法合成了納米粒子。在合成納米顆粒并用PEG對其進行表面修飾后,通過CCK-8測定評估納米顆粒的生物相容性。通過體外(克隆形成實驗和CCk-8測試),體內(nèi)和凝膠劑量測定評估BFO和Bi Gd O3納米顆粒對放射治療中的輻射劑量增強的影響。使用具有的4T1乳腺癌BALB/c雌性荷瘤鼠進行體內(nèi)癌癥放射療。用于MR和CT圖像的體模研究的弛豫時間(R2)和CT值(HU)顯示出與納米顆粒和濃度的線性關(guān)...

【文章頁數(shù)】:120 頁

【學(xué)位級別】:博士

【文章目錄】:
摘要
Abstract
ABBREVIATION
CHAPTER 1 INTRODUCTION
    1.1 Background
    1.2 Problems and significances
    1.3 Radiation therapy
        1.3.1 External radiation therapy
        1.3.2 Internal Radiation Therapy-Brachytherapy
    1.4 Interaction of photon with matter
        1.4.1 Photoelectric effect
        1.4.2 Compton scattering
        1.4.3 Pair Production
    1.5 Nanoparticles in medicine
        1.5.1 Toxicity of nanoparticles
        1.5.2 Enhanced radiation dose by high atomic number nanoparticles
        1.5.3 Gold nanoparticles
        1.5.4 Bismuth nanoparticles
        1.5.5 Gadolinium nanoparticles
        1.5.6 Delivery of nanoparticles and drug in tumor
    1.6 Research contents in this study
CHAPTER 2 EXPERIMENTAL PROCEDUR
    2.1 Synthesis and characterization nanoparticles
        2.1.1 Materials
        2.1.2 Synthesis and characterization of BFO nanoparticles
        2.1.3 Synthesis and characterization of BiGd03 nanoparticles
    2.2 Gel dosimetry
    2.3 Biological experiment-(in vitro,in vivo)
        2.3.1 Cancer cell lines
        2.3.2 Cell culture
        2.3.3 The cytotoxicity of the nanoparticles
        2.3.4 Clonogenic assay
        2.3.5 In vitro radiotherapy (BFO nanoparticles)
    2.4 In vivo experiment (BiGdO3-PEG nanoparticles)
    2.5 MRI and CT imaging
    2.6 Inductive Heating Property
    2.7 Statistical analysis
CHAPTER 3 BISMUTH FERRITE NANOPARTICLES AS RADIOSENSITIZER
    3.1 Introduction
    3.2 Characterization of synthesized nanoparticles (BFO)
    3.3 In vitro experiment results
        3.3.1 Biocompatibility (BFO-NPs)
        3.3.2 In vitro-radiosensitization
    3.4 Gel results
    3.5 Imaging results
        3.5.1 T_2 MR imaging
        3.5.2 CT imaging
    3.6 Inductive heating property
    3.7 BFO nanoparticles-loaded brachytherapy spacer
    3.8 Discussion
    3.9 Conclusion
CHAPTER 4 BISMUTH GADOLINIUM OXIDE NANOPARTICLES ASRADIOSENSITIZER
    4.1 Introduction
    4.2 Characterization of synthesized nanoparticles (BiGdO_3)
    4.3 In vitro experiment-BiGdO_3 nanoparticles
        4.3.1 In vitro Biocompatibility
        4.3.2 In vitro radiosensitizing results-BiGdO_3
    4.4 Gel dosimetry results-BiGdO_3
    4.5 In vivo results-BiGdO_3
    4.6 Imaging-phantom and in vivo results-BiGdO_3
        4.6.1 MRI
        4.6.2 CT
    4.7 Discussion
    4.8 Conclusion
CHAPTER 5 BISMUTH- BASED NANOPARTICLES ASRADIOSENSITIZER
    5.1 Introduction
    5.2 Brachytherapy sources
    5.3 Monte Carlo simulations
        5.3.1 Calculation of TG-43 parameters
    5.4 Nanoparticles dose enhancement-simulation
        5.4.1 MCNP-Monte Carlo
        5.4.2 Analytical simulation
    5.5 Validation of radiation sources-MCNP
    5.6 Radiation Dose Enhancement-Results
        5.6.1 MCNP code
        5.6.2 Analytical method
    5.7 Discussion
    5.8 Conclusions
CHAPTER 6 CONCLUSION
    6.1 Thesis conclusion
    6.2 Study innovation
REFERENCES
ACKNOWLEDGMENT
RESUME /PUBLICATINS



本文編號:4005702

資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/shoufeilunwen/yxlbs/4005702.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶ecf86***提供,本站僅收錄摘要或目錄,作者需要刪除請E-mail郵箱bigeng88@qq.com
国产色第一区不卡高清| 欧洲一区二区三区自拍天堂| 日韩一级一片内射视频4k| 亚洲黄香蕉视频免费看| 青青草草免费在线视频| 欧美日韩黑人免费观看| 精品欧美日韩一二三区| 亚洲中文在线观看小视频| 亚洲中文字幕有码在线观看| 欧美一区二区三区五月婷婷| 果冻传媒精选麻豆白晶晶| 91人妻久久精品一区二区三区 | 粉嫩国产美女国产av| 免费人妻精品一区二区三区久久久| 精品少妇一区二区三区四区| 好吊一区二区三区在线看| 久久热麻豆国产精品视频| 亚洲av又爽又色又色| 欧美一区日韩一区日韩一区| 日本一二三区不卡免费| 国产一区二区三区丝袜不卡| 91国内视频一区二区三区| 亚洲精品国男人在线视频| 色涩一区二区三区四区| 午夜激情视频一区二区| 日本免费一本一二区三区| 亚洲国产日韩欧美三级| 日本高清视频在线播放| 免费大片黄在线观看日本| 日本熟妇熟女久久综合| 国产内射一级一片内射高清视频 | 日本加勒比系列在线播放| 91人妻久久精品一区二区三区| 国产又粗又硬又长又爽的剧情| 一区二区不卡免费观看免费| 国产欧美日产久久婷婷| 老熟妇乱视频一区二区| 夫妻性生活黄色录像视频| 黄片免费观看一区二区| 国产精品成人免费精品自在线观看| 日本中文在线不卡视频|