本文選題：子宮肌瘤 + 中醫(yī)傳承輔助平臺系統(tǒng)��； 參考：《廣州中醫(yī)藥大學》2017年博士論文

【摘要】：目的:1.基于中醫(yī)傳承輔助平臺系統(tǒng)(V2.5)研究分析子宮肌瘤的組方規(guī)律,研究內(nèi)容包含藥物頻次結(jié)果、常用藥對、核心組合及新方等,系統(tǒng)研究中醫(yī)藥治療子宮肌瘤的組方規(guī)律。2.基于中醫(yī)傳承輔助平臺系統(tǒng)(V2.5)研究李坤寅教授治療子宮肌瘤的用藥規(guī)律,采用數(shù)據(jù)挖掘技術(shù),總結(jié)李坤寅教授治療子宮肌瘤的治療特色。方法:1.擬定檢索策略,檢索中國知網(wǎng)數(shù)據(jù)庫(CNKI),使用高級檢索,檢索項選"全文",檢索詞"子宮肌瘤"、"ve瘕",匹配項選"模糊",排序方式為"時間",共檢索出1997年～2016年中醫(yī)藥治療子宮肌瘤的臨床相關(guān)文獻1021篇。依據(jù)納入標準和排除標準,最終篩選出337首方劑。將上述方劑由雙人錄入中醫(yī)傳承輔助平臺系統(tǒng)(V2.5)的相應(yīng)模塊,采用軟件的規(guī)則分析、改進互信息法、復(fù)雜系統(tǒng)熵聚類及無監(jiān)督的熵層次聚類等方法進行分析,獲取藥物頻次結(jié)果、常用藥對、核心規(guī)律、核心組合、新方分析等結(jié)果,并以可視網(wǎng)絡(luò)圖展示出來,分析現(xiàn)代醫(yī)家治療子宮肌瘤的用藥規(guī)律。2.門診收集并篩選李坤寅教授治療子宮肌瘤的臨床有效病例,由雙人錄入中醫(yī)傳承輔助平臺系統(tǒng)(V2.5),采用軟件的規(guī)則分析、改進互信息法、復(fù)雜系統(tǒng)熵聚類及無監(jiān)督的熵層次聚類等方法進行分析。根據(jù)李坤寅教授在患者月經(jīng)期和非月經(jīng)期用藥思路的變化,分別進行總體方劑分析、月經(jīng)期方劑分析和非月經(jīng)期方劑分析,總結(jié)李坤寅教授治療子宮肌瘤的用藥規(guī)律,探討其治療子宮肌瘤的治療特色。成果:1.文獻方劑研究:(1)中藥治療子宮肌瘤的337首方劑中,共有270味藥物,用藥頻次排在前十位的藥物為:莪術(shù)、當歸、三棱、赤芍、桃仁、茯苓、黃芪、牡蠣、桂枝、牡丹皮。以活血化瘀藥物為主。月經(jīng)期用藥的方劑有40首,包含135味藥物,月經(jīng)期用藥頻次排在前十位的藥物為:當歸、黃芪、黨參、蒲黃、益母草、香附、赤芍、白術(shù)、茜草、茯苓。非月經(jīng)期用藥的方劑有144首,包含204味藥物,非月經(jīng)期用藥頻次排在前十位的藥物為:莪術(shù)、三棱、當歸、桃仁、赤芍、茯苓、桂枝、牡丹皮、黃芪、牡蠣。(2)整體用藥中,3～5味的核心藥物組合共有37個,治療子宮肌瘤的新處方7個。2.臨床方劑研究(1)李坤寅教授治療子宮肌瘤患者40例,共有方劑296首,將所有藥物頻次進行統(tǒng)計,共有144味中藥,藥物頻次之和為3924次�？傮w藥物頻次排在前十位的藥物為:甘草、茯苓、竹茹、柏子仁、山藥、山茱萸、續(xù)斷、合歡皮、陳皮、熟地黃。月經(jīng)期藥物頻次排在前十位的藥物為:甘草、益母草、續(xù)斷、三七、蒲黃、山藥、海螵蛸、黨參、茜草、白術(shù)。非月經(jīng)期藥物頻次排在前十位的藥物為:甘草、茯苓、柏子仁、竹茹、山茱萸、山藥、合歡皮、陳皮、熟地黃、淫羊藿�？傮w藥性排在前三位的藥物是:平、溫、寒。月經(jīng)期排在前三位的藥物是:溫、平、寒。非月經(jīng)期排在前三位的藥物是:平、溫、寒�？傮w用藥五味排在前三位的是:甘、苦、辛。月經(jīng)期和非月經(jīng)期用藥五味排在前三位的是:甘、苦、辛�？傮w用藥歸經(jīng)排在前五位的藥物分別是腎、肝、脾、肺、心。月經(jīng)期用藥歸經(jīng)排在前五位的藥物分別是肝、脾、腎、心、胃。非月經(jīng)期用藥歸經(jīng)排在前五位的藥物分別是腎、脾、肝、肺、心。(2)基于關(guān)聯(lián)規(guī)則分析常用藥物組合有柏子仁-茯苓(-竹茹,合歡皮,甘草,熟地黃),山茱萸-山藥(-茯苓,柏子仁-茯苓),月經(jīng)期常用藥物組合有益母草-甘草(-蒲黃,續(xù)斷,三七),蒲黃-三七(-續(xù)斷,益母草)。核心組合有竹茹-海螵蛸-茯苓,竹茹-黨參-茜草,竹茹-橘紅-枳實,竹茹-海螵蛸-白花蛇舌草,海螵蛸-牡蠣-龍骨等�；趶�(fù)雜系統(tǒng)熵聚類得出的新處方有竹茹-海螵蛸-茯苓-茜草,法半夏-山藥-蓮須-枳實,山茱萸-淫羊藿-益母草-熟地黃-山藥-地骨皮,續(xù)斷-橘紅-合歡皮-首烏藤-菟絲子,海螵蛸-三七-益母草-茯苓-蒲黃。(3)3～5味的核心藥物組合共有46個,治療子宮肌瘤的新處方5個。結(jié)論:1.中醫(yī)傳承輔助平臺系統(tǒng)對子宮肌瘤文獻進行分析,治療子宮肌瘤的藥物中以活血化瘀藥物為主,其中包含桂枝茯苓丸的藥物。核心組合的藥物包括活血藥、行氣藥、補血藥、溫陽藥、軟堅散結(jié)藥。2.中醫(yī)傳承輔助平臺系統(tǒng)對李坤寅教授治療子宮肌瘤的有效病例處方分析,月經(jīng)期用藥和非月經(jīng)期用藥存在明顯差異(包括藥物頻次、藥物組合、新處方等),在不同月經(jīng)周期的用藥思路亦不同。總體用藥和非月經(jīng)期用藥中健脾滲濕藥、補腎藥、安神藥、化痰藥等應(yīng)用頻率較高,月經(jīng)期用藥則以活血化瘀藥、化瘀止血藥、益氣健脾藥等應(yīng)用頻率較高。研究結(jié)果為中醫(yī)藥治療子宮肌瘤在臨床和基礎(chǔ)研究方面提供新的依據(jù),但仍需要專家判讀、實驗研究等方法的驗證。3.李坤寅教授治療子宮肌瘤一般采用中藥湯劑、中成藥(桔荔散結(jié)片)、配合飲食指導(dǎo)等多種方法綜合治療,以達到治療疾病的目的。
[Abstract]:Objective: 1. based on the inheritance auxiliary platform system (V2.5) of traditional Chinese medicine (V2.5) research and analysis of the law of uterine fibroids, the research contents include the results of drug frequency, common drug pair, core combination and new prescription, and systematically study the prescription of Chinese medicine for the treatment of uterine fibroids.2. based on the inheritance auxiliary platform system of traditional Chinese medicine (V2.5) to study the treatment of the uterus by Professor Li Kunyin The rule of drug use, using data mining technology to summarize the treatment characteristics of Professor Li Kunyin in the treatment of uterine myoma. Methods: 1. to draw up the retrieval strategy, retrieve the Chinese knowledge network database (CNKI), use advanced retrieval, search term "full text", search term "uterus myoma", "ve", "fuzzy" matching item, sort way for "time", and retrieve a total of 1997. 1021 articles related to the treatment of uterine myoma in Chinese medicine from year to 2016. According to the inclusion criteria and the exclusion criteria, 337 prescriptions were selected. The above-mentioned prescription was introduced into the corresponding modules of the traditional Chinese Medicine Inheritance auxiliary platform system (V2.5), and the software rules were used to change into the mutual information method, the entropy clustering of complex system and the unsupervised entropy. Analytic hierarchy clustering method was used to obtain the results of drug frequency, common drug pair, core rule, core combination, new analysis and so on. The results were displayed with visual network diagram and analyzed by modern doctors in the treatment of uterine fibroids in.2. clinic. The traditional Chinese Medicine Inheritance auxiliary platform system (V2.5), using the software rules analysis, improving the mutual information method, the entropy clustering of complex system and the unsupervised entropy hierarchical clustering method. According to Professor Li Kunyin's changes in the menstrual and non menstrual period, the general prescription analysis, the menstrual phase prescription analysis and non menstruation were carried out respectively. Period prescription analysis, summarize the medicine rule of Professor Li Kunyin in the treatment of uterine myoma and discuss the therapeutic characteristics of the treatment of uterine myoma. Results: 1. literature and prescription study: (1) among 337 prescriptions for the treatment of myoma of uterus, there are 270 drugs in the treatment of uterine myoma, and the first ten drugs in the first ten places are zedoary turmeric, angelica, prism, red peony, peach kernel, Poria, astragalus, peony In the menstrual period, there are 40 prescriptions for the use of blood circulation and removing stasis drugs. There are 135 prescriptions for the menstrual period, including 135 drugs and the first ten drugs in the menstrual period: Danggui, Radix Astragali, Radix Codonopsis, Pu Huang, Herba Leonuri, Radix Paeoniae Paeoniae, Atractylodes, tuckahoe. There are 144 prescriptions for non menstrual period, including 204 drugs and non menstrual medication. Frequency of the first ten drugs are: zedoary, prism, angelica, peony, peony, peony, peony, peony, Poria, cinnamon, cinnamon, peony, peony, astragalus, oysters. (2) a total of 3~5 core drug combinations in 37, 7.2. Clinical Prescriptions for the treatment of uterine myoma (1) 40 cases of myoma of uterus treated by Professor Li Kunyin, with a total of 296 prescriptions, will all The frequency of drug frequency is 144 traditional Chinese medicine, and the frequency of drug frequency is 3924 times. The general drug frequency of the first ten drugs is Glycyrrhiza, Poria, bamboo Ru, Bai Ziren, yam, dogwood, dip, the skin of Acacia, tangerine, the top ten drugs in the menstrual period: licorice, Leonurus, continuum, 37, Pu Huang, yam, sea The top ten drugs in the non menstrual period are: licorice, tuckahoe, cypress, bamboo Ru, Fructus Corni, yam, acacia, tangerine, radix rehmanniae, Epimedium. The first three drugs are: flat, warm, cold. The first three drugs in the period of menstruation are warm, flat, cold. The first three drugs in the non menstrual period. Material is: flat, warm, cold. The total drug five in the top three are: Gansu, bitter, symplectic. Menstrual period and non menstrual period five taste in the top three are: Gan, bitter, symplectic. The drugs in the first five are the kidney, liver, spleen, lung, heart. The drugs of the first five are the liver, spleen, kidney, heart, stomach. Non menstrual period. The drugs used in the first five places are kidney, spleen, liver, lung, heart. (2) based on association rules, the commonly used drug combinations are cypress kernel Poria (- bamboo Ru, leucacea, licorice, Radix Rehmanniae), cornel - yam (- Poria cocos, cypress Poria cocos), and a combination of Herba Leonuri - Glycyrrhiza (- Pu Huang, dip, 37) and Pu Huang - 37 (- continued) during the period of menstruation The core combination includes bamboo Ru - cuttlebone - Poria, bamboo Ru - Codonopsis - alizardo, bamboo Ru - orange red - trifoliate orange, bamboo Ru - cuttlebone - oysters - oysters - Oyster - keel and so on. The new prescription based on complex system entropy clustering has bamboo Ru - sea cuttlebone - tuckahoe - alizari, French yam - Lotus - Fructus aurantii, Cornus officinalis - Herba Leonurus - ripening Radix rehmanniae - yam, dipede, dip - orange red - Acacia skin - CVF - dodder, cuttlebone - 37 - Leonurus tuckahoe - Pu Huang. (3) 3~5 core drug combinations, 46 new prescriptions for the treatment of uterine myoma. Conclusion: 1. traditional Chinese medicine auxiliary platform system for uterine myoma is analyzed, and the drugs for the treatment of uterine myoma are alive. It includes the drugs of Guizhi Fuling pill, including the medicine of Guizhi Fuling pill. The core combination medicine includes the blood activating medicine, the gas medicine, the blood supplement medicine, the warm Yang medicine, the soft hard powder and the.2. traditional Chinese Medicine Inheritance auxiliary platform system to analyze the effective cases of Professor Li Kunyin in the treatment of uterine myoma. There are obvious differences in the use of drugs in the menstrual period and the non menstrual period. Drug frequency, drug combination, new prescription, etc., different medication ideas in different menstrual cycles are also different. In the general and non menstrual period, the use of invigorating the spleen and wetting medicine, kidney tonifying medicine, Anshen medicine, phlegm medicine and so on is high, and the use of drugs for activating blood and removing blood stasis, removing blood stasis and promoting spleen medicine is higher in the period of menstrual period. Medicine for the treatment of uterine myoma provides a new basis for clinical and basic research, but it is still necessary for the experts to judge and test the methods of experimental research..3. professor Li Kunyin commonly used Chinese medicine decoction, Chinese patent medicine (orange lyi powder), combined with dietary guidance and other methods to achieve the purpose of treatment of the disease.
【學位授予單位】：廣州中醫(yī)藥大學
【學位級別】：博士
【學位授予年份】：2017
【分類號】：R273

【參考文獻】

相關(guān)期刊論文 前10條

1 盧洪慧;王友梅;;自擬化積湯聯(lián)合西藥治療對子宮肌瘤及內(nèi)膜組織ER、PR、Bax的影響[J];全科醫(yī)學臨床與教育;2017年01期

2 朱杰華;陳喜悅;黃健;李玉姿;姚金淦;;自擬消ve經(jīng)驗方內(nèi)服聯(lián)合米非司酮對子宮肌瘤患者子宮肌瘤體積和血清E2變化的影響[J];海南醫(yī)學;2017年02期

3 丁小游;呂杰強;;婦疾康陰道給藥法治療子宮肌瘤的臨床效果觀察[J];數(shù)理醫(yī)藥學雜志;2016年12期

4 楊鑒冰;王菁;雒挺托;;丹鱉膠囊治療婦科疾病臨床舉隅[J];現(xiàn)代中醫(yī)藥;2016年04期

5 李向一;孫秀彬;鹿玉蓮;申振偉;陳亞飛;唐芳;薛付忠;;子宮肌瘤與乳腺增生關(guān)聯(lián)性的隊列研究[J];山東大學學報(醫(yī)學版);2016年09期

6 劉輝;;賀氏火針在子宮肌瘤中的應(yīng)用及機理探討[J];中醫(yī)外治雜志;2016年03期

7 郭少瓊;林新;楊翠霞;何蔚莊;張月娥;李煒明;;溫針灸配合橘荔散結(jié)丸治療子宮肌瘤臨床觀察[J];上海針灸雜志;2016年04期

8 崔社通;王欣;;基于中醫(yī)傳承輔助系統(tǒng)分析治療原發(fā)性痛經(jīng)的方劑用藥規(guī)律[J];山東中醫(yī)雜志;2016年04期

9 李有杰;唐世峰;劉澤旺;劉恭喜;曹曉靖;孫長崗;;基于中醫(yī)傳承輔助系統(tǒng)的治療卵巢癌方劑組方規(guī)律分析[J];山東中醫(yī)雜志;2016年03期

10 劉輝;;賀氏火針對子宮肌瘤并發(fā)癥月經(jīng)過多的影響[J];中醫(yī)外治雜志;2016年01期

相關(guān)博士學位論文 前1條

1 陳妮妮;中藥治療子宮肌瘤的證治規(guī)律分析及療效評價的循證研究[D];北京中醫(yī)藥大學;2015年

相關(guān)碩士學位論文 前5條

1 李盛堯;針刺“曲骨組穴”治療子宮肌瘤臨床療效觀察[D];北京中醫(yī)藥大學;2016年

2 朱美;消瘤方治療子宮肌瘤氣滯血瘀證的臨床療效觀察[D];云南中醫(yī)學院;2016年

3 李佳;3939例子宮肌瘤患者的臨床病例分析[D];吉林大學;2015年

4 蘇恒香;基于數(shù)據(jù)挖掘探討肖承`敖淌謚瘟貧嗄衣殉滄酆險韉撓靡┕媛蒣D];北京中醫(yī)藥大學;2014年

5 韓蘭香;從肝郁探討子宮肌瘤和乳腺增生的相關(guān)性[D];黑龍江中醫(yī)藥大學;2012年

，

本文編號：1906240