【摘要】：研究背景尋常痤瘡是一種毛囊皮脂腺的慢性炎癥性疾病,其發(fā)病機(jī)制與眾多因素有關(guān),也是皮膚科發(fā)病率較高的疾病之一。近年來,“皮膚屏障”逐漸成為學(xué)者們重要的關(guān)注點(diǎn),因其與皮膚疾病的形成可能存在一定的相關(guān)性。隨著無創(chuàng)性皮膚生理測試儀器的更新應(yīng)用,皮膚角質(zhì)層含水量、經(jīng)表皮失水量(TEWL)、皮膚油脂、皮膚表面PH值、皮膚色素(黑色素和血紅素)含量及皮膚彈性值等多項(xiàng)皮膚生理指標(biāo)可被有效地檢測出來,測試者們可以更為客觀直接地了解皮膚狀況。越來越多的皮膚生理研究表明,痤瘡患者的皮膚屏障功能出現(xiàn)了異常,很多皮膚生理指標(biāo)數(shù)據(jù)統(tǒng)計(jì),如角質(zhì)層含水量、經(jīng)表皮失水量(TEWL)、皮膚油脂等,與正常人相比,存在明顯差異;而且在臨床治療過程中,皮膚生理指標(biāo)也會發(fā)生變化,隨著痤瘡的治愈,指標(biāo)會趨向正常、穩(wěn)定,但也有其它指標(biāo)暫未發(fā)現(xiàn)有明顯的差異,需要進(jìn)一步的研究。因此,越來越多的學(xué)者認(rèn)為皮膚屏障的損傷可能與痤瘡的發(fā)生發(fā)展相關(guān),有效地保護(hù)及修復(fù)皮膚屏障對控制和治療痤瘡起著重要的作用。研究目的通過對輕中度痤瘡患者與正常人面部皮膚各生理指標(biāo)的測定比較,分析其中的差異,探討皮膚生理指標(biāo)的異常與痤瘡發(fā)生發(fā)展的相關(guān)性,為今后對痤瘡的預(yù)防、控制及治療提供理論基礎(chǔ)。研究方法選取114例受試對象,實(shí)驗(yàn)組為痤瘡患者57例,其中男24例,女33例,平均年齡為22歲;對照組為正常健康志愿者57例,其中男24例,女33例,平均年齡為22歲。運(yùn)用無創(chuàng)性皮膚生理功能檢測儀,對受試者的前額、鼻部、臉頰三個(gè)部位,進(jìn)行角質(zhì)層含水量、經(jīng)表皮失水量(TEWL)、皮膚油脂、皮膚表面PH、皮膚黑色素、皮膚血紅素以及皮膚彈性的測量,另外,對受試者的眼角只做彈性測量。統(tǒng)計(jì)分析痤瘡患者與正常人各部位的各項(xiàng)指標(biāo)的差異。研究結(jié)果實(shí)驗(yàn)組痤瘡患者前額、臉頰的角質(zhì)層含水量低于對照組正常人,差異有統(tǒng)計(jì)學(xué)意義(P0.05);實(shí)驗(yàn)組痤瘡患者前額、臉頰的經(jīng)表皮失水量(TEWL)高于對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);實(shí)驗(yàn)組痤瘡患者前額、鼻部、臉頰的皮膚油脂和血紅素含量高于對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。另外,實(shí)驗(yàn)組前額、鼻部、臉頰的PH值、黑色素含量、彈性值,鼻部的角質(zhì)層含水量和經(jīng)表皮失水量(TEWL),以及眼角的彈性值與對照組相比,差異均無統(tǒng)計(jì)學(xué)意義(P㧐0.05)。研究結(jié)論痤瘡患者面部油脂分泌過多,對于前額、臉頰這樣的痤瘡好發(fā)部位,其經(jīng)表皮失水量(TEWL)和血紅素含量高,角質(zhì)層含水量低,皮膚屏障功能出現(xiàn)損傷,關(guān)于痤瘡患者面部的黑色素含量、PH值和彈性值與正常人比較,沒有明顯差異。
[Abstract]:Background Acne vulgaris is a chronic inflammatory disease of hair follicle sebaceous gland. The pathogenesis of acne vulgaris is related to many factors and is one of the diseases with high incidence in dermatology. In recent years, "skin barrier" has gradually become an important concern of scholars, because it may be related to the formation of skin diseases. With the renewal and application of the non-invasive skin physiological testing instrument, the water content of the cuticle of the skin, the water loss of the skin through the epidermis, the (TEWL), oil and the PH value of the skin surface, Skin physiological indexes such as skin pigment (melanin and heme) content and skin elasticity can be effectively detected, and the subjects can get a more objective and direct understanding of the skin condition. More and more studies on skin physiology show that the skin barrier function of acne patients is abnormal. Many skin physiological data statistics, such as water content of cuticle, transepidermis loss of water content of (TEWL), skin oil and so on, are compared with those of normal people. There are obvious differences; And in the course of clinical treatment, the physiological indexes of skin will also change. With the cure of acne, the indexes will tend to be normal and stable, but there are still no obvious differences in other indexes, which need to be further studied. Therefore, more and more scholars believe that the damage of skin barrier may be related to the occurrence and development of acne, and the effective protection and repair of skin barrier play an important role in the control and treatment of acne. Objective to investigate the correlation between the abnormality of skin physiological indexes and the occurrence and development of acne by comparing the physiological indexes of facial skin between patients with mild to moderate acne and normal people, and to prevent acne in the future, and explore the relationship between the abnormality of skin physiological indexes and the occurrence and development of acne, in order to prevent acne in the future. Control and treatment provide a theoretical basis. Methods A total of 114 subjects were enrolled in this study. The experimental group consisted of 57 acne patients (24 males and 33 females with an average age of 22 years) and 57 healthy volunteers (24 males and 33 females with an average age of 22 years) and 57 healthy volunteers (24 males and 33 females with an average age of 22 years). Using the non-invasive skin physiological function detector, the water content of the cuticle, the water content of (TEWL), skin, the melanin of PH, skin on the skin surface, the water content of the cuticle, the water loss of the skin through the epidermis and the melanin of the skin surface of the subjects were measured. Measurements of skin heme and skin elasticity, in addition, subjects' eye angles were measured only by elasticity. Statistical analysis of acne patients and normal people in different parts of the index differences. Results the water content of cuticle in forehead and cheek of acne patients in experimental group was lower than that in control group (P0.05). The (TEWL) of frontal and cheek transepidermal water loss in experimental group was higher than that in control group, the difference was statistically significant (P0.05). The skin fat and heme contents of acne patients in the experimental group were significantly higher than those in the control group (P0.05). In addition, the PH value of forehead, nose, cheek, melanin content, elastic value, water content of the keratinous layer of the nose, (TEWL), and elastic value of the eye angle of the experimental group were compared with those of the control group. There was no significant difference between the two groups (P < 0.05). Conclusion there is too much oil secretion in the face of acne patients. For acne, such as forehead and cheek, the content of (TEWL) and heme in the epidermis is high, the water content in the stratum corneum is low, and the function of skin barrier is damaged. There was no significant difference in facial melanin content, PH and elasticity between acne patients and normal controls.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R758.733

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