【摘要】：目的:通過(guò)對(duì)缺血修飾白蛋白(IMA)、天門(mén)冬氨酸氨基轉(zhuǎn)移酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脫氫酶(LDH)、?-羥丁酸脫氫酶(HBDH)、超敏肌鈣蛋白T(HSCTNT)血漿水平的研究,獲取早期診斷急性冠脈綜合征(ACS)及病情危險(xiǎn)程度的生化指標(biāo)。方法:病例組選取2012年4月至2016年11月在新疆醫(yī)科大學(xué)附屬中醫(yī)醫(yī)院心血管內(nèi)科住院的ACS患者601例,通過(guò)GRACE(THE GLOBAL REGISTRY OF ACUTE CORONARY EVENTS)危險(xiǎn)評(píng)分計(jì)算器進(jìn)行危險(xiǎn)分層:低危組226例、中危組227例高危組148人,另選取健康體檢者190例作為對(duì)照組。分別對(duì)病例組與對(duì)照組進(jìn)行上述生化標(biāo)志物的檢測(cè)與分析。結(jié)果:IMA在各危險(xiǎn)分層組與對(duì)照組之間的比較有統(tǒng)計(jì)學(xué)意義(P0.05),低危組與高危組之間比較有統(tǒng)計(jì)學(xué)意義(P0.05)但中危組與低危組、高危組與中危組之間沒(méi)有統(tǒng)計(jì)學(xué)意義(P0.05)。AST:低危組與對(duì)照組之間的比較沒(méi)有統(tǒng)計(jì)學(xué)意義(P0.05),中危組與對(duì)照組、高危組與對(duì)照組之間的比較有統(tǒng)計(jì)學(xué)意義(P0.05),各危險(xiǎn)分層組之間的比較有統(tǒng)計(jì)學(xué)意義(P0.05)CK:各危險(xiǎn)分層組與對(duì)照組之間的比較有統(tǒng)計(jì)學(xué)意義(P0.05);低危組與中危組之間的比較沒(méi)有統(tǒng)計(jì)學(xué)意義(P0.05),中危組與高危組、高危組與低危組之間的比較有統(tǒng)計(jì)學(xué)意義(P0.05)。CK-MB:各危險(xiǎn)分層組與對(duì)照組之間的比較有統(tǒng)計(jì)學(xué)意義(P0.05),各危險(xiǎn)分層組之間的比較有統(tǒng)計(jì)學(xué)意義(P0.05)LDH:各危險(xiǎn)分層組與對(duì)照組之間的比較有統(tǒng)計(jì)學(xué)意義(P0.05),低危組與中危組、高危組與低危組之間有統(tǒng)計(jì)學(xué)意義(P0.05),中危組與高危組之間沒(méi)有統(tǒng)計(jì)學(xué)意義(P0.05)。HBDH:各危險(xiǎn)分層組與對(duì)照組之間的比較有統(tǒng)計(jì)學(xué)意義(P0.05),低危組與中危組沒(méi)有統(tǒng)計(jì)學(xué)意義(P0.05),中危組與高危組、高危組與低危組之間有統(tǒng)計(jì)學(xué)意義(P0.05)。HSCTNT:各危險(xiǎn)分層組與對(duì)照組之間的比較有統(tǒng)計(jì)學(xué)意義(P0.05),各危險(xiǎn)分層組之間的比較有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:(1)IMA、AST、CK、LDH、HBDH:在ACS早期診斷及危險(xiǎn)分層中有一定的參考價(jià)值。(2)CK-MB、HSCTNT:其檢測(cè)對(duì)ACS的早期診斷具有統(tǒng)計(jì)學(xué)意義(P0.05),對(duì)ACS的危險(xiǎn)分層有統(tǒng)計(jì)學(xué)意義(P0.05)。
[Abstract]:Objective: to investigate the effects of ischemia modified albumin (IMA), aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH),?-hydroxybutyrate dehydrogenase) (HBDH), To study the plasma level of hypertroponin T (HSCTNT) and to obtain biochemical indexes for early diagnosis of acute coronary syndrome (ACS) (ACS) and the risk of acute coronary syndromes (ACS). Methods: from April 2012 to November 2016, a total of 601 ACS patients in the Department of Cardiovascular Medicine, affiliated Hospital of traditional Chinese Medicine, Xinjiang Medical University, were selected for risk stratification by GRACE (THE GLOBAL REGISTRY OF ACUTE CORONARY EVENTS) risk score calculator: 226 cases in low risk group. There were 227 cases in the middle risk group and 148 cases in the high risk group. 190 healthy persons were selected as the control group. The above biochemical markers were detected and analyzed in the case group and the control group respectively. Results: there were significant differences in IMA between the risk stratified group and the control group (P0.05), and between the low risk group and the high risk group (P0.05), but between the middle risk group and the low risk group. There was no significant difference between high risk group and middle risk group (P0.05) between low risk group and control group (P0.05). The comparison between the high risk group and the control group was statistically significant (P0.05), and the comparison between the risk stratification group and the control group was statistically significant (P0.05). There was no significant difference between the low risk group and the middle risk group (P0.05), but there was no significant difference between the middle risk group and the high risk group. The comparison between high risk group and low risk group was statistically significant (P0.05). The comparison between CK-MB: risk stratification group and control group was statistically significant (P0.05). The comparison between the risk stratification group and the control group was statistically significant (P0.05). There were significant differences between the LDH: risk stratification group and the control group (P0.05), the low risk group and the middle risk group. There was significant difference between the high risk group and the low risk group (P0.05), but there was no statistical significance between the middle risk group and the high risk group (P0.05). There was no significant difference between the low risk group and the middle risk group (P0.05), while the middle risk group and the high risk group had no statistical significance (P0.05). There was significant difference between high risk group and low risk group (P0.05) between). HSCTNT: risk stratification group and control group (P0.05), and between each risk stratification group had statistical significance (P0.05). Conclusion: (1) IMA,AST,CK,LDH,HBDH: has certain reference value in the early diagnosis and risk stratification of ACS. (2) the detection of CK-MB,HSCTNT: has statistical significance in the early diagnosis of ACS (P0.05). The risk stratification of ACS was statistically significant (P0.05).
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R541.4

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