PCI相關心肌梗死的危險因素及預后回顧性分析
發(fā)布時間:2019-01-02 19:18
【摘要】:目的:觀察廣西醫(yī)科大學第一附屬醫(yī)院西院心血管內科PCI相關心肌梗死的發(fā)生率及危險因素,為PCI相關心肌梗死的防治提供一定的臨床參考。方法:符合入組條件276例術前cTn I正常的患者擇期行經(jīng)皮冠狀動脈介入治療(PCI)術,根據(jù)術后48h內肌鈣蛋白I(cTnI)檢測值分為三組,I組(cTnI正常組,cTnI≤0.033 ng/mL,167例);II組(PCI相關心肌損傷組,0.033 ng/mLcTnI≤0.165 ng/mL,51例);III組(PCI相關心肌梗死組,cTnI0.165ng/mL,58例)。通過對三組患者術前一般臨床資料、血生化指標、冠脈造影特點及PCI術中操作參數(shù)指標等因素進行觀察比較,利用Logistic回歸分析PCI相關心肌梗死的重要危險因素。術后6-24個月隨訪,比較PCI術后MACE發(fā)生率。結果:276例擇期PCI患者中,術后c TnI在正常范圍內患者有167例(60.50%),cTn I超過正常值上限但小于5倍患者有51例(18.47%),cTnI超過正常值上限5倍患者有58例(21.01%)。與I組對比,II組、III組患者術前hs-CRP[(1.21±0.56)vs(2.22±0.83)vs(3.66±1.39)mg/L,P0.001]差異有統(tǒng)計學意義,且cTnI與hs-CRP呈正相關;II組、III組中多支血管病變(39.53%vs 64.71%vs 75.86%,P0.001),C型血管病變(47.90%vs 56.86%vs 74.14%,P0.001)患者所占比率要高于I組;比較三組患者PCI術中操作參數(shù):發(fā)現(xiàn)I組與II組及III組在支架數(shù)目[(1.14±0.35)vs(1.27±0.45)vs(1.55±0.56)個,P0.001]、支架總長度[(30.16±14.27)vs(35.94±14.23)vs(38.68±17.10)mm,P=0.042]、球囊總個數(shù)[(2.03±0.52)vs(2.39±0.14)vs(3.12±1.18)個,P=0.002]、囊擴張最大壓力[(13.62±4.46)vs(14.58±4.36)vs(15.67±3.18)atm,P=0.042]方面比較,三者間差異均有統(tǒng)計學意義;Logistic回歸分析結果顯示,hs-CRP、支架總長度、多枚支架植入、C型血管病變是PCI相關心肌梗死的重要危險因素。術后6-24個月隨訪,發(fā)現(xiàn)I組中有3例患者發(fā)生MACE(2例心力衰竭,1例再次行TVR),II組中有4例患者發(fā)生MACE(1例心力衰竭,1例再發(fā)急性心肌梗死,2例再次行TVR),III組中有2例患者發(fā)生MACE(1例心力衰竭,1例再發(fā)急性心肌梗死),三組患者短期MACE發(fā)生率(1.80%vs 7.84%vs 3.45%,P=0.103)比較,差異無統(tǒng)計學意義。結論:1、我院西院心血管內科PCI相關心肌損傷發(fā)生率為18.47%,PCI相關心肌梗死發(fā)生率為21.01%;2、hs-CRP、支架總長度、多枚支架植入、C型血管病變是PCI相關心肌梗死的重要危險因素;3、術后6-24個月隨訪,PCI相關心肌梗死并不增加患者MACE發(fā)生率。
[Abstract]:Objective: to observe the incidence and risk factors of PCI related myocardial infarction in the Department of Cardiovascular Medicine, West Hospital, first affiliated Hospital of Guangxi Medical University, and to provide some clinical reference for the prevention and treatment of PCI related myocardial infarction. Methods: 276 patients with normal cTn I before operation underwent percutaneous coronary intervention (PCI). According to the values of cardiac troponin I (cTnI) in 48 hours after operation, they were divided into three groups: group I (cTnI normal group, cTnI 鈮,
本文編號:2398875
[Abstract]:Objective: to observe the incidence and risk factors of PCI related myocardial infarction in the Department of Cardiovascular Medicine, West Hospital, first affiliated Hospital of Guangxi Medical University, and to provide some clinical reference for the prevention and treatment of PCI related myocardial infarction. Methods: 276 patients with normal cTn I before operation underwent percutaneous coronary intervention (PCI). According to the values of cardiac troponin I (cTnI) in 48 hours after operation, they were divided into three groups: group I (cTnI normal group, cTnI 鈮,
本文編號:2398875
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