發(fā)布時間：2018-09-04 13:18

【摘要】：目的:運用中醫(yī)傳承輔助平臺v2.5初步探究中醫(yī)藥治療年齡相關(guān)性黃斑變性的用藥規(guī)律和特點,為中醫(yī)藥治療年齡相關(guān)性黃斑變性提供一條新的思緒。方法:在有關(guān)數(shù)據(jù)庫中檢索中醫(yī)藥治療年齡相關(guān)性黃斑變性的文獻,建立數(shù)據(jù)庫,進行相應(yīng)的方劑分析,挖掘出治療年齡相關(guān)性黃斑變性的各味中藥使用頻次及組方規(guī)律,并得出新處方。結(jié)果:通過對196首方劑168味藥分析,高頻次的藥物為茯苓、當歸、枸杞子、白術(shù)、丹參、甘草、黃芪、山藥、川芎、熟地黃等,藥物分類以補虛藥、活血化瘀藥、利水滲濕藥、清熱藥、止血藥等為主。設(shè)定支持度為30、置信度為0.6,得到34個常用藥對。設(shè)定相關(guān)度為6,懲罰度為2,挖掘出含有隱性規(guī)律的3味中藥的核心組合,共計23組。最終得出4個新方組合:①黨參、陳皮、白術(shù)、楮實子、菟絲子、枸杞子、五味子②大薊、茜草、姜黃、生地黃、小薊、牡丹皮③當歸、薏苡仁、川芎、紅花④白扁豆、砂仁、蓮子心、人參。結(jié)論:1.基于頻次統(tǒng)計法、改進的互信息法、復(fù)雜系統(tǒng)熵聚類、無監(jiān)督的熵層次聚類等數(shù)據(jù)挖掘技術(shù),為分析治療年齡相關(guān)性黃斑變性方劑的用藥規(guī)律提供了一定的科學憑據(jù)。2.年齡相關(guān)性黃斑變性以滋養(yǎng)肝腎、健脾利濕、活血化瘀為主要治法。3.中醫(yī)傳承輔助平臺v2.5的核心組合和備選新處方為臨床提供了新的參考,為開發(fā)新藥奠定理論基礎(chǔ),但還需臨床研究和實驗研究等進一步評價。
[Abstract]:Objective: to explore the characteristics of drug use of Chinese medicine in the treatment of age-related macular degeneration by means of v2.5, and to provide a new thought for the treatment of age-related macular degeneration with traditional Chinese medicine. Methods: the literature on the treatment of age-related macular degeneration with traditional Chinese medicine was searched in the database, the database was established, the prescription analysis was carried out, and the usage frequency and prescription rule of each Chinese medicine for treatment of age-related macular degeneration were excavated. And get a new prescription. Results: according to the analysis of 168 medicines of 196 prescriptions, the high frequency drugs were Poria cocos, Angelica sinensis, Fructus Lycii, Atractylodes macrocephala, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Radix Astragali, Chinese yam, Ligusticum chuanxiong, Radix Rehmanniae, etc. Heat-clearing drugs, hemostatic drugs and so on. The set support was 30, the confidence was 0.6, and 34 common drug pairs were obtained. The correlation degree was 6 and the penalty degree was 2. The core combination of 3 kinds of traditional Chinese medicine containing recessive law was excavated, 23 groups in total. Finally, four new combinations of Codonopsis chinensis, Chen Pei, Atractylodes macrocephala, Fructus Broussoneae, Cuscuta chinensis, Fructus Lycii, Schisandra chinensis, alizarin, turmeric, Radix Rehmanniae, artichoke, Peony 3 Angelica, Coix seed, Ligusticum chuanxiong, Safflower 4 White lentils, Amomum villosum, Lotus seed heart, ginseng. Conclusion 1. Based on frequency statistics, improved mutual information method, entropy clustering of complex systems, unsupervised entropy hierarchical clustering and other data mining techniques, this paper provides some scientific evidence for analyzing the rule of drug use of age-related macular degeneration prescription. Age-related macular degeneration to nourish the liver and kidney, spleen and dampness, blood circulation and blood stasis as the main treatment. 3. The core combination and alternative new prescriptions of v2.5 provide a new reference for clinical practice and lay a theoretical foundation for the development of new drugs, but further evaluation is needed in clinical and experimental studies.
【學位授予單位】：南京中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R276.7

【參考文獻】

相關(guān)期刊論文 前10條

1 孫元培;郭曉霞;;基于中醫(yī)傳承輔助平臺挖掘姜良鐸教授治療慢性乙型肝炎方藥規(guī)律[J];中國實驗方劑學雜志;2017年06期

2 蔡琳;彭鵬;郭甜;;丹參藥理作用及臨床研究進展[J];山東化工;2016年17期

3 方一惟;冉起;馮馳;吳成富;;中西醫(yī)結(jié)合治療濕性老年黃斑變性臨床觀察[J];中國醫(yī)學工程;2016年08期

4 高輝;趙曉東;李煥麗;;劉懷棟教授治療年齡相關(guān)性黃斑變性臨床經(jīng)驗[J];現(xiàn)代中西醫(yī)結(jié)合雜志;2016年21期

5 鄭宏;錢紅濤;盧婷婷;陸相朋;潘丹萍;鄭攀;;基于中醫(yī)傳承輔助系統(tǒng)的中醫(yī)藥治療兒童抽動障礙用藥規(guī)律研究[J];中國實驗方劑學雜志;2016年17期

6 李隨;周鮮琳;王斌;;中西醫(yī)結(jié)合治療老年性黃斑變性38例療效觀察[J];世界最新醫(yī)學信息文摘;2016年49期

7 宋湘梅;汪旬;陳青山;許丹;張國明;;中西醫(yī)結(jié)合護理配合二陳二黃湯治療濕性老年黃斑變性20例[J];河南中醫(yī);2015年07期

8 游昕;熊大國;郭志斌;商友劍;;茯苓多種化學成分及藥理作用的研究進展[J];安徽農(nóng)業(yè)科學;2015年02期

9 劉如秀;劉宇;汪艷麗;彭杰;劉金鳳;;當歸的藥理作用[J];西部中醫(yī)藥;2014年11期

10 王勁松;;滋腎清肝明目經(jīng)驗方辨治老年性黃斑變性臨床研究[J];遼寧中醫(yī)藥大學學報;2014年11期

，

本文編號：2222220