【摘要】：目的:探討排石顆粒配合鹽酸坦洛新對電子輸尿管軟鏡治療大于2cm腎結(jié)石的臨床療效。方法:將2015年03月-2017年03月江蘇大學附屬醫(yī)院90例應(yīng)用輸尿管軟鏡治療直徑大于2cm的腎石病患者按隨機分配的方法分為實驗組和對照組,每組各45例。實驗組配合中藥排石顆粒及鹽酸坦洛新緩釋片,對照組僅配合鹽酸坦洛新。服藥后每周復(fù)查一次,療程四周或至排石干凈。分別于第2周、第4周進行療效判定。其觀察指標為結(jié)石清除率、腎絞痛發(fā)生概率、結(jié)石的排凈時間以及膀胱過度活動癥(OABSS)評分。結(jié)果:1.實驗組結(jié)石清除率為97.8%,而對照組的清除率為86.7%,差異具有統(tǒng)計學意義(P0.05);2.治療組結(jié)石排凈天數(shù)為(5.6±1.67)天,對照組結(jié)石排凈天數(shù)為(12.7±2.63)天,差異具備統(tǒng)計學意義(P0.05);3.實驗組術(shù)后發(fā)生腎絞痛概率為8.9%,而對照組術(shù)后發(fā)生腎絞痛概率為24.4%,差異具備統(tǒng)計學意義(P0.05);4.實驗組OABSS評分為(5.3±1.19),對照組OABSS評分為(11.2±2.67),差異具有統(tǒng)計學意義(P0.05)。結(jié)論:排石顆粒配合鹽酸坦洛新對電子輸尿管軟鏡治療大于2.0cm結(jié)石患者具有結(jié)石清除率高、腎絞痛發(fā)生概率小、結(jié)石排出時間短以及并發(fā)癥少的治療優(yōu)勢。
[Abstract]:Objective: to investigate the clinical effect of Paishi granule combined with Tanluoxin Hydrochloride in the treatment of renal calculi larger than 2cm by electronic ureteroscopy. Methods: from March 2015 to March 2017, 90 patients with nephrolithiasis whose diameter was larger than 2cm were divided into experimental group (n = 45) and control group (n = 45). The experimental group combined with Paishi granules and Tanluoxin Hydrochloride sustained release tablets, while the control group only combined with Tanluoxin Hydrochloride. Recheck once a week after taking the medicine, the course of treatment or until the stone clean. The curative effect was evaluated at week 2 and week 4 respectively. The parameters were stone clearance rate, probability of occurrence of renal colic, time of stone removal and (OABSS) score of bladder hyperactivity. The result is 1: 1. The stone clearance rate of the experimental group was 97.8, while that of the control group was 86.7. The difference was statistically significant (P0.05). The days of stone drainage were (5.6 鹵1.67) days in the treatment group and (12.7 鹵2.63) days in the control group. The difference was statistically significant (P0.05). The probability of renal colic in the experimental group was 8.9 and that in the control group was 24.40.The difference was statistically significant (P0.05). The OABSS score was (5.3 鹵1.19) in the experimental group and (11.2 鹵2.67) in the control group (P0.05). Conclusion: Paishi granule combined with Tanluoxin Hydrochloride has the advantages of high removal rate of calculi, low probability of occurrence of renal colic, short time of stone excretion and fewer complications in patients with soft endoscopy of electronic ureter than in patients with 2.0cm calculi.
【學位授予單位】：江蘇大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R699.2

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