本文關(guān)鍵詞：中醫(yī)藥預(yù)防ERCP術(shù)后胰腺炎的Meta分析，由筆耕文化傳播整理發(fā)布。

中醫(yī)藥預(yù)防ERCP術(shù)后胰腺炎的Meta分析

Role of Traditional Chinese Medicine In Prevention of Post-ERCP Pancreatitis： A Meta-analysis

[1] [2] [3]

DENG Fang-fan, CAO Miao, ZHANG Wen-xing （1. Hu＇nan University of Chinese Medicine, Changsha Hu＇nan 410208, China; 2. The First Affiliated Hospital of Hu＇nan University of Ch

[1]湖南中醫(yī)藥大學(xué),湖南長沙410208; [2]湖南中醫(yī)藥大學(xué)第一附屬醫(yī)院,湖南長沙410007

文章摘要：目的：評價中醫(yī)藥預(yù)防ERCP術(shù)后胰腺炎（post-ERCP pancreatitis,PEP）的有效性和安全性。方法：計算機檢索Pub Med、CNKI、VIP和Wan Fang Data數(shù)據(jù)庫,時間均為建庫至2014年9月,收集中醫(yī)藥防治ERCP術(shù)后急性胰腺炎的隨機對照試驗。由兩名研究者獨立選擇文獻(xiàn)、提取資料,應(yīng)用Cochrane系統(tǒng)評價手冊（5.3.3版）標(biāo)準(zhǔn)結(jié)合Jadad評分法進(jìn)行質(zhì)量評價,使用Rev Man5.3.3軟件進(jìn)行統(tǒng)計分析。結(jié)果：經(jīng)篩選最終納入10篇文獻(xiàn)進(jìn)行Meta分析,共974例患者。Meta分析結(jié)果顯示：（1）高淀粉酶血癥發(fā)生率：兩組差異均有統(tǒng)計學(xué)意義[OR：0.40 95%CI：0[0.28,0.56]Z=5.255,P〈0.001],說明治療組術(shù)后高淀粉酶血癥發(fā)生率小于對照組;（2）急性胰腺炎發(fā)生率：兩組差異有統(tǒng)計學(xué)意義[OR：0.3295%CI：[0.18,0.56]Z=33.93,P〈0.001],治療組術(shù)后急性胰腺炎發(fā)生率小于對照組;（3）其他指標(biāo)：術(shù)后2~4 h血淀粉酶差異無統(tǒng)計學(xué)意義;術(shù)后12、24、48、72 h血淀粉酶水平、血淀粉酶恢復(fù)時間及腹痛（或臨床癥狀）緩解時間、IL-6水平、CRP水平兩組間差異有計學(xué)意義。結(jié)論：本系統(tǒng)評價結(jié)果顯示,有較強證據(jù)表明中醫(yī)藥較單純西醫(yī)預(yù)防ERCP術(shù)后胰腺炎有優(yōu)勢,不良反應(yīng)少。但是相關(guān)試驗存在一定的方法學(xué)問題,質(zhì)量較低,尚需更多研究進(jìn)一步驗證。

Abstr：Objective： To evaluate the effectiveness and safety of traditional Chinese medicine in the prevention of post-endoscopic retrograde cholangiopancreatography（ERCP） pancreatitis（PEP）. Methods： The following databases such as Pub Med, CNKI, Wanfangang VIP were searched to collect the randomized controlled trials（RCTs） on traditional Chinese medicine in the prevention of PEP from intiation establishment of database to September, 2014. The selection of studies, assessment of methodological quality and data extraction were performed independently by two reviewers according to the Cochrane systematic review methods and Jadad score system, and Meta-analyses were performed by using Rev Man 5.3.3 software. Results： A total of 10 RCTs involving 974 cases were included after the selection. The results of Meta-analyses indicated that compared with the control group, the experimental group for post ERCP incidence rate of hyperamylasemia was superior（OR：0.40 95%CI：[0.28,0.56] Z=5.255, P〈0.001）, incidence rate of acute pancreatitis（OR：0.32 95%CI：[0.18,0.56] Z=33.93,P 0.001）, with significant differences. There was no statistical difference on blood amylase of 2-4hours after the operation. blood amylase of 12, 24, 48 and 72 hours after the operation, the levels of IL-6 and CRP,the recovery time of blood amylase and the relief time of abdominal pain（or clinical symptom） were significantly different. Conclusions： The evaluation results showed that there was strong evidence indicated that traditional Chinese medicine have advantage over single therapy of western medicine, but there are some methodological problems in the studies. Due to the poor quality and method of the included studies, more well designed RCTs should be performed.

文章關(guān)鍵詞：

Keyword：:traditional Chinese medicine prevention post-ERCP pancreatitis meta-analysis

  本文關(guān)鍵詞：中醫(yī)藥預(yù)防ERCP術(shù)后胰腺炎的Meta分析，，由筆耕文化傳播整理發(fā)布。