本文選題：喘安糖漿 + 慢性阻塞性肺疾病��； 參考：《湖北民族學(xué)院》2017年碩士論文

【摘要】：目的:探討喘安糖漿對(duì)慢性阻塞性肺疾病的臨床療效及通過(guò)實(shí)驗(yàn)研究喘安糖漿的止咳、祛痰、解熱作用。方法:臨床療效:納入患者為利川市民族中醫(yī)院自2016年1月到2017年1月期間住院病例,共58例。對(duì)照組和喘安組各29例,對(duì)照組懫用西醫(yī)常規(guī)治療,喘安組在西醫(yī)常規(guī)治療基礎(chǔ)上加喘安糖漿口服治療,觀察對(duì)患者臨床癥狀、體征、hsCRP、PCT、肺功能、動(dòng)脈血?dú)夥治龅挠绊�。�?shí)驗(yàn)研究:小鼠50只,雌雄各半,按體重隨機(jī)分成空白對(duì)照組、陽(yáng)性藥止咳橘紅膠囊對(duì)照組(0.65g/kg)、喘安糖漿高劑量組(4.0g/kg)、喘安糖漿中劑量組(2.0g/kg)、喘安糖漿低劑量組(1.0g/kg),每組10只,采用氨水引咳法后觀察5min中的咳嗽次數(shù)和咳嗽潛伏時(shí)間。小鼠50只,雌雄各半,實(shí)驗(yàn)分組、給藥劑量同上,采用酚紅祛痰法后觀察對(duì)小鼠酚紅排泄量的影響。取大鼠60只,雌雄各半,按體重隨機(jī)分成喘安糖漿高(2.8g/kg)、中(1.4g/kg)、低劑量組(0.7g/kg)陽(yáng)性藥止咳橘紅膠囊對(duì)照組(0.46g/kg)、模型組和空白組,采用內(nèi)毒素致熱法后觀察對(duì)內(nèi)毒素致大鼠發(fā)熱的影響。結(jié)果:1.喘安組與對(duì)照組經(jīng)3個(gè)月觀察后比較,在咳嗽、咳痰、氣短、自汗、水腫、腹脹6項(xiàng)中醫(yī)證侯改善上有顯著性差異(p0.05)。2.喘安組與對(duì)照組經(jīng)3個(gè)月觀察后比較,在咳嗽、咳痰量、痰液性質(zhì)、咯痰難易、發(fā)熱、濕羅音6項(xiàng)癥狀體征改善上有顯著性差異(p0.05)。3.觀察治療三月后喘安組的肺功能指標(biāo)FEV1、FEV1比預(yù)計(jì)值、FVC、FEV1比FVC比對(duì)照組有明顯改善(p0.05)。4.觀察治療三月后喘安組的血?dú)夥治鲋笜?biāo)PaO2、PaCO2比對(duì)照組有明顯改善(p0.05)。5.觀察治療14天后喘安組的hsCRP和PCT比對(duì)照組有明顯改善(p0.05)。6.喘安糖漿劑高、中、低劑量組與空白組比,能明顯的增加小鼠咳嗽的潛伏期和降低咳嗽次數(shù)。7.各給藥組同空白對(duì)照組比較,喘安糖漿高、中、低劑量和陽(yáng)性藥對(duì)小鼠呼吸道酚紅的排泄量有增加的趨勢(shì),說(shuō)明喘安糖漿有一定的祛痰作用。8.各組動(dòng)物給藥前體溫?zé)o明顯差異性(p0.05),給致熱劑后模型組的不同時(shí)間體溫明顯升高(p0.05)。不同時(shí)間各給藥組分別同模型組比較,給致熱劑后1h、2h、3h,各給藥組體溫明顯降低(p0.05);給致熱劑后4h喘安糖漿各組體溫明顯降低(p0.05),而陽(yáng)性對(duì)照組無(wú)明顯差異性(p0.05);給致熱劑后5h,喘安糖漿高劑量組體溫明顯降低(p0.05);其他各組無(wú)明顯差異性(p0.05),表明喘安糖漿可以抑制脂多糖引起的大鼠體溫升高,作用時(shí)間達(dá)5小時(shí)以上,有明顯解熱作用。結(jié)論:提示喘安糖漿可改善COPD患者咳嗽、咳痰、氣短、自汗、水腫、腹脹癥候。喘安糖漿可改善COPD患者咳嗽、咳痰量、痰液性質(zhì)、咯痰難易、發(fā)熱、濕羅音癥狀體征。喘安糖漿可改善COPD穩(wěn)定期患者的肺功能、血?dú)夥治鲋笜?biāo)、hsCRP和PCT。喘安糖漿口服給藥可明顯減少氨水引起的小鼠咳嗽次數(shù)、明顯延長(zhǎng)咳嗽潛伏期,具有止咳作用;可使小鼠呼吸道酚紅排出量增加,具有祛痰作用;對(duì)脂多糖引起的大鼠發(fā)熱有明顯的抑制作用,具有解熱作用。表明喘安糖漿具有止咳、祛痰、解熱作用。
[Abstract]:Objective: To investigate the clinical effect of Chuan an syrup on chronic obstructive pulmonary disease and to study the effect of tuscking, expectorant and antipyretic effect through experimental study of pant syrup. Methods: the clinical efficacy of the patients was included in the patients from January 2016 to January 2017 in Lichuan national traditional Chinese medicine hospital. There were 58 cases in the control group and Chuan an group, and the control group was treated with western medicine. The effect of Chuan an group on the clinical symptoms, signs, hsCRP, PCT, lung function and arterial blood gas analysis was observed on the basis of traditional western medicine routine treatment. Experimental study: 50 mice were divided into blank control group according to weight, and the positive drug of antitussive orange red capsule control group (0.65g/kg) and high pant syrup were high. The dose group (4.0g/kg), the dose group (2.0g/kg) in pant syrup, and the low dose group (1.0g/kg) of pant syrup (1.0g/kg), the cough times and the latent time of coughing in 5min were observed after the cough method of ammonia water. In mice, 50 mice and male and male, the experimental group, the dose of the same, the effect of phenol red expectorant method on the excretion of phenol red in mice. 60 rats, male and female, were randomly divided into wheezing syrup high (2.8g/kg), middle (1.4g/kg), low dose group (0.7g/kg) positive antitussive orange red capsule control group (0.46g/kg), model group and blank group, the effect of endotoxin induced heat observation on endotoxin induced fever in rats. Results: 1. pantine group and control group were compared after 3 months' observation. There were significant differences in 6 TCM Syndromes of cough, expectoration, shortness of breath, self perspiration, edema and abdominal distention (P0.05). After 3 months of observation, there was a significant difference in cough, expectoration, sputum nature, phlegm difficulty, fever, and 6 symptoms of wet rales (P0.05).3. observation for the treatment of lung function in the group of Chuan an after March FEV1, FEV1, FVC and FEV1 were significantly better than those of the control group (P0.05) compared with the control group (P0.05).4. observation on the blood gas analysis index PaO2 after March, and PaCO2 significantly improved (P0.05).5. observation group (P0.05).5. observation after 14 days. Compared with the blank group, the latent period of coughing in mice and the decrease of the number of coughing.7. were significantly increased. The high, middle, low dose, and positive drugs had a tendency to increase the excretion of phenol red in the respiratory tract of mice, indicating that there was no obvious difference in body temperature before the administration of.8. in each group of animals. The body temperature of the model group was significantly increased (P0.05) at different time after the heat agent (P0.05). The body temperature of each group was significantly lower than that of the model group at different time. After giving the heat agent 1H, 2h, 3h, the body temperature of each group was significantly decreased (P0.05). After the heat agent, the body temperature of 4H panting syrup in 4H was decreased (P0.05), but there was no significant difference in the positive control group (P0.05); After 5h, the body temperature of the high dose group was obviously decreased (P0.05), and there was no significant difference in other groups (P0.05). The results showed that pasthmatic syrup could inhibit the temperature rise of rats induced by lipopolysaccharide for more than 5 hours, and there was an obvious antipyretic effect. Conclusion: Wheezing syrup can improve the cough, expectoration, shortness of breath, perspiration and edema in COPD patients. Pant syrup can improve the cough, expectoration, sputum, phlegm, phlegm, fever, and wet sound symptoms in COPD patients. Wheezing syrup can improve the lung function of patients in the stable period of COPD. The oral administration of hsCRP and PCT. pant syrup can obviously reduce the number of cough caused by ammonia water and prolong the latent period of cough. It has the effect of relieving cough. It can increase the excretion of phenol red in the respiratory tract of mice and have the effect of eliminating phlegm. It has obvious inhibitory effect on the fever caused by lipopolysaccharide in rats, and has the antipyretic effect. It shows that pant syrup has the effect of relieving cough, eliminating phlegm and antipyretic.
【學(xué)位授予單位】：湖北民族學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R259

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 晏峰;周穎;徐偉珍;;慢性阻塞性肺疾病患者血清甘膽酸、C反應(yīng)蛋白與肺、肝功能改變的相關(guān)性研究[J];檢驗(yàn)醫(yī)學(xué);2017年02期

2 劉圣金;王瑞;吳德康;吳露婷;喻斌;佟書(shū)娟;楊歡;王宇華;楊文國(guó);楊江;孫云飛;;礦物藥青礞石對(duì)AECOPD痰熱證大鼠肺組織NF-κB表達(dá)及血清中相關(guān)因子的干預(yù)作用[J];中成藥;2017年02期

3 王明航;李建生;;中醫(yī)藥治療慢性阻塞性肺疾病臨床療效評(píng)價(jià)研究現(xiàn)狀[J];中醫(yī)雜志;2017年03期

4 林先剛;譚麗;黃威;肖陽(yáng);劉自兵;;姜黃素對(duì)慢性阻塞性肺疾病大鼠輔助性T細(xì)胞17與調(diào)節(jié)性T細(xì)胞的調(diào)節(jié)作用[J];北京中醫(yī)藥大學(xué)學(xué)報(bào);2017年01期

5 周霞;馮娜娜;李靜;陳翠翠;宋元林;白春學(xué);金先橋;周建;;連花急支片在慢性支氣管炎大鼠中的藥效學(xué)研究[J];復(fù)旦學(xué)報(bào)(醫(yī)學(xué)版);2017年01期

6 盧緒香;張偉;;慢性阻塞性肺疾病“ABCD”分級(jí)的中醫(yī)解析[J];遼寧中醫(yī)雜志;2017年01期

7 李杰;張立山;于維霞;周紹忠;王林洋;魏欣欣;;蔞芩止嗽煎對(duì)青霉素在慢性阻塞性肺疾病急性加重期痰熱證大鼠模型肺組織轉(zhuǎn)運(yùn)能力的影響[J];中華中醫(yī)藥雜志;2017年01期

8 郭貴州;宋文龍;甘桃梅;蘭智慧;;基于MMP-9/TIMP-1失衡研究補(bǔ)益宗氣方干預(yù)慢性阻塞性肺疾病大鼠氣道重塑的機(jī)制[J];中華中醫(yī)藥雜志;2016年11期

9 任玉嬌;張偉;;從三焦論述慢性阻塞性肺疾病穩(wěn)定期分組中醫(yī)藥干預(yù)探討[J];時(shí)珍國(guó)醫(yī)國(guó)藥;2016年10期

10 苗苗;卜小寧;;慢性阻塞性肺疾病患者血漿腦鈉肽增高的機(jī)制[J];首都醫(yī)科大學(xué)學(xué)報(bào);2016年05期

相關(guān)碩士學(xué)位論文 前1條

1 潘晶晶;益氣滌痰逐瘀方“滌痰”和“逐瘀”藥對(duì)調(diào)節(jié)COPD氣道重塑TGF-β1/Smad通路的實(shí)驗(yàn)研究[D];云南中醫(yī)學(xué)院;2016年

，

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