ERCP治療肝泡型包蟲病的有效性分析
本文選題:肝泡型包蟲病 + ERCP ; 參考:《青海大學(xué)》2017年碩士論文
【摘要】:目的:探討經(jīng)內(nèi)鏡下逆行胰膽管造影術(shù)(ERCP)在肝泡型包蟲病(HAE)的臨床應(yīng)用中的療效。方法:收集于2012年1月-2016年11月在青海大學(xué)附屬醫(yī)院就診,診斷為肝泡型包蟲病并行ERCP治療的患者資料,將資料分為4組:A組為合并黃疸的HAE患者術(shù)前行ERCP減黃組B組為無(wú)黃疸的AE患者術(shù)前ERCP治療組C組為HAE患者術(shù)后膽道并發(fā)癥的ERCP治療組D組為終末期合并黃疸HAE患者的ERCP治療組。分別記錄患者一般情況,測(cè)定及比較術(shù)前、術(shù)后肝功能指標(biāo),并觀察術(shù)后癥狀改善及早期并發(fā)癥的發(fā)生情況,對(duì)終末期患者進(jìn)行生存質(zhì)量和生存時(shí)間的隨訪,并行分別統(tǒng)計(jì)學(xué)分析,得出結(jié)果。結(jié)果:A組(14例)中13例患者黃疸逐漸消退,1例患者轉(zhuǎn)行經(jīng)皮肝穿膽道引流術(shù)(PTCD)后癥狀好轉(zhuǎn),術(shù)后與術(shù)前肝功能比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),ERCP術(shù)后14天與術(shù)前肝功能child-pugh分級(jí)、黃疸程度比較差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。B組患者隨機(jī)分為ERCP組(10例)和未接受ERCP組(13例),兩組患者在拔管時(shí)間對(duì)比上差異有統(tǒng)計(jì)學(xué)意義(P0.05);C組中(10例)1例膽道狹窄患者治愈,9例膽漏患者,8例治愈,1例轉(zhuǎn)行手術(shù)治療后治愈,總治愈率90%。D組患者術(shù)后3天、7天、1月肝功能較術(shù)前比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),不同時(shí)間點(diǎn)的患者生活質(zhì)量評(píng)分的差異有統(tǒng)計(jì)學(xué)意義。結(jié)論:可切除肝泡型包蟲合并梗阻性黃疸患者術(shù)前ERCP治療可有效改善肝功能、降低黃疸指數(shù)。可切除肝泡型包蟲無(wú)黃疸患者術(shù)前ERCP留置ENBD,可降低手術(shù)后膽道并發(fā)癥發(fā)生率。ERCP可作為泡型肝包蟲術(shù)后膽道并發(fā)癥(膽漏、膽管狹窄)的治療選擇。ERCP可改善終末期泡肝合并梗阻性黃疸患者生存質(zhì)量。
[Abstract]:Objective: to evaluate the clinical effect of endoscopic retrograde cholangiopancreatography (ERCP) in the treatment of hepatic alveolar hydatid disease (HAE). Methods: data were collected from January 2012 to November 2016 in the affiliated Hospital of Qinghai University for diagnosis of hepatic alveolar hydatidosis treated with ERCP. The data were divided into 4 groups: group A was HAE patients with jaundice before operation, group B was AE patients without jaundice, group B was AE patients without jaundice before operation, group C was HAE patients, group C was postoperative biliary complications of HAE patients, group D was end-stage complicated with jaundice HAE. The patients were treated with ERCP. The general condition of the patients was recorded, the liver function indexes before and after operation were measured and compared, and the improvement of postoperative symptoms and the occurrence of early complications were observed, and the quality of life and survival time were followed up. The results are obtained by parallel statistical analysis. Results among 14 cases in group A, jaundice gradually subsided and 1 patient had improved symptoms after percutaneous transhepatic biliary drainage. There was a significant difference in postoperative liver function between 14 days after operation and 14 days after operation (P 0.05) and child-pugh grade of liver function before operation. The degree of jaundice was significantly different. Group B was randomly divided into ERCP group (n = 10) and ERCP group (n = 13). There was significant difference in extubation time between two groups. 9 cases of bile leakage were cured, 8 cases were cured and 1 case was cured after operation. The total cure rate of patients in group D was 3 days after operation and 7 days after operation. The difference of liver function in 1 month was statistically significant compared with that before operation (P 0.05). The difference of quality of life score of patients at different time points was statistically significant. Conclusion: preoperative ERCP therapy in patients with resectable hepatic alveolar hydatid and obstructive jaundice can effectively improve liver function and decrease jaundice index. ERCP indwelling enBDD before operation in patients with resectable hepatic alveolar hydatid without jaundice can reduce the incidence of postoperative biliary complications. ERCP can improve the quality of life in patients with obstructive jaundice.
【學(xué)位授予單位】:青海大學(xué)
【學(xué)位級(jí)別】:碩士
【學(xué)位授予年份】:2017
【分類號(hào)】:R532.32
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