本文選題：太赫茲時(shí)域光譜技術(shù) + 太赫茲成像�。� 參考：《中央民族大學(xué)》2017年碩士論文

【摘要】：太赫茲時(shí)域光譜技術(shù)(THz-TDS)是20世紀(jì)80年代以來(lái)新發(fā)展起來(lái)的一種技術(shù),利用光電導(dǎo)的方法產(chǎn)生THz輻射脈沖,具有帶寬大、信噪比高、能夠在室溫中工作等優(yōu)點(diǎn)。THz脈沖透射樣品或者在樣品表面發(fā)生反射,測(cè)量THz電場(chǎng)強(qiáng)度與時(shí)間的變化關(guān)系,對(duì)測(cè)得的數(shù)據(jù)進(jìn)行經(jīng)傅里葉變換后得到頻域上幅值與相位的變化關(guān)系,從而獲得樣品的信息。太赫茲技術(shù)憑借其獨(dú)特的優(yōu)勢(shì)在中草藥的質(zhì)量檢測(cè)、定性定量和光譜成像分析中得到廣泛的應(yīng)用。本文主要利用THz-TDS技術(shù)和光譜成像技術(shù)在中草藥光譜檢測(cè)及腫瘤診斷方面做了如下幾個(gè)部分的工作:首先,利用太赫茲時(shí)域光譜技術(shù)對(duì)不同含水量的天麻及不同鉻含量的明膠樣品分別進(jìn)行了測(cè)量,得到其THz光譜,分別計(jì)算獲得天麻脫水過(guò)程中與頻率相關(guān)的吸收系數(shù)曲線,及不同鉻含量明膠與頻率相關(guān)的吸收系數(shù)曲線。發(fā)現(xiàn)含水量與吸收系數(shù)、明膠中鉻含量與吸收系數(shù)都呈線性正相關(guān)的關(guān)系,從而根據(jù)測(cè)量的結(jié)果對(duì)樣品的質(zhì)量進(jìn)行評(píng)估。其次,利用太赫茲時(shí)域光譜技術(shù)重新檢測(cè)了青蒿素及其衍生物(雙氫青蒿素、青蒿琥酯、蒿甲醚)等四種青蒿素類藥物在太赫茲波段的吸收特性,分別得到它們?cè)谔囟úǘ?0.2-2.7THz)的吸收光譜。并對(duì)實(shí)驗(yàn)結(jié)果與現(xiàn)有的指紋譜數(shù)據(jù)進(jìn)行了對(duì)比分析。結(jié)果顯示,絕大部分的共振峰與文獻(xiàn)[24]中的一致,但峰位和強(qiáng)度略有差異,并且有新的峰位出現(xiàn)。然后,討論了樣品制備和數(shù)據(jù)處理方法對(duì)數(shù)據(jù)結(jié)果的影響,以及分子結(jié)構(gòu)與峰位的關(guān)系。并基于此進(jìn)一步確認(rèn)了數(shù)據(jù)的有效性。結(jié)果為進(jìn)一步研究青蒿素及其衍生物的藥性提供參考,并對(duì)其無(wú)損鑒別、定量定性分析提供了一種快速高效的鑒定方法。最后,運(yùn)用太赫茲時(shí)域光譜成像技術(shù)對(duì)肝臟正常組織與肝臟腫瘤組織、腎臟正常組織與腎臟腫瘤組織分別進(jìn)行探測(cè),分別得到了他們的太赫茲時(shí)域光譜圖,經(jīng)數(shù)據(jù)處理得到了腫瘤組織與正常組織的吸收系數(shù)光譜圖,并對(duì)正常組織與腫瘤組織的吸收光譜分別進(jìn)行了分析。然后利用逐點(diǎn)掃描太赫茲成像系統(tǒng)分別對(duì)肝臟、腎臟的腫瘤組織進(jìn)行了成像,分別得到它們?cè)跁r(shí)域顯示模式和頻域顯示模式下的THz重構(gòu)圖,成像結(jié)果能較好區(qū)分出腫瘤組織與正常組織。最后,對(duì)成像結(jié)果進(jìn)行了討論,提出了實(shí)驗(yàn)過(guò)程中出現(xiàn)的問(wèn)題,并針對(duì)已有的問(wèn)題提供了解決的辦法,為以后太赫茲技術(shù)在腫瘤診斷領(lǐng)域的研究奠定了基礎(chǔ)。
[Abstract]:Terahertz time-domain spectroscopy (THz-TDS) is a new technology developed since 1980s. It uses photoconductive method to generate THz radiation pulse, which has a large bandwidth and high signal-to-noise ratio (SNR). It can work at room temperature and other advantages. THz pulse transmission samples or on the surface of the sample reflect, measure the change of THz electric field intensity and time, and get the change of amplitude and phase in frequency domain by Fourier transform. In order to obtain the sample information. Terahertz technology has been widely used in the quality detection, qualitative and quantitative analysis and spectral imaging analysis of Chinese herbal medicine with its unique advantages. In this paper, THz-TDS and spectral imaging techniques are used in the detection of Chinese herbal medicine spectrum and tumor diagnosis as follows: first, The THz spectra of Gastrodia elata and gelatin samples with different water content and different chromium content were measured by terahertz time-domain spectroscopy. The absorption coefficient curves related to frequency in the dehydration process of Gastrodia elata were calculated, respectively. And the absorption coefficient curve of different chromium content gelatin and frequency correlation. It was found that there was a linear positive correlation between water content and absorption coefficient, chromium content in gelatin and absorption coefficient, so the quality of the sample was evaluated according to the measured results. Secondly, the absorption characteristics of artemisinin and its derivatives (dihydroartemisinin, artesunate, artemisinin) in terahertz band were re-examined by THz time-domain spectroscopy. Their absorption spectra of 0.2-2.7 THZ were obtained respectively. The experimental results are compared with the existing fingerprint data. The results show that most of the resonance peaks are consistent with those in literature [24], but the peak position and intensity are slightly different, and new peaks appear. Then, the influence of sample preparation and data processing on the data results and the relationship between molecular structure and peak position are discussed. Based on this, the validity of the data is further confirmed. The results provided a rapid and efficient method for further study of artemisinin and its derivatives, nondestructive identification and quantitative qualitative analysis of artemisinin and its derivatives. Finally, terahertz time-domain imaging technique was used to detect normal liver tissue and liver tumor tissue, kidney normal tissue and renal tumor tissue, and their terahertz time-domain spectra were obtained. The absorption coefficient spectra of tumor and normal tissues were obtained by data processing, and the absorption spectra of normal and normal tissues were analyzed respectively. Then the liver and kidney tumor tissues were examined by point-by-point scanning terahertz imaging system, and their THz reconstructed images in time-domain and frequency-domain display modes were obtained, respectively. The imaging results can distinguish tumor tissue from normal tissue. Finally, the imaging results are discussed, the problems in the experiment are put forward, and the solutions to the existing problems are provided, which will lay a foundation for the future research of terahertz technology in the field of tumor diagnosis.
【學(xué)位授予單位】：中央民族大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R284;R730.4;O657.3

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