本文選題：膝骨性關(guān)節(jié)炎 + 瘀血阻滯型　； 參考：《福建中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:觀察赤木洗劑凝膠治療早期膝骨性關(guān)節(jié)炎臨床療效、安全性,總結(jié)該藥的特點(diǎn)及優(yōu)缺點(diǎn),為臨床應(yīng)用赤木洗劑凝膠治療該類型膝骨性關(guān)節(jié)炎提供理論依據(jù),推廣該中藥凝膠劑型在臨床中的應(yīng)用。方法:收集山東省文登整骨醫(yī)院骨關(guān)節(jié)三科自2016年02月至2016年08月門診病人符合納入標(biāo)準(zhǔn)的早期瘀血阻滯型膝骨性關(guān)節(jié)炎的患者40例,分為實(shí)驗(yàn)組、對照組。兩組患者均同時口服硫酸氨基葡萄糖膠囊0.628gtid,實(shí)驗(yàn)組患者使用赤木洗劑凝膠外敷10gbid,對照組患者使用赤木洗劑燙洗bid,兩組均以10d為1個療程,連續(xù)使用3個療程。實(shí)驗(yàn)組:每次使用凝膠治療前用濕溫毛巾清潔患膝皮膚,取赤木洗劑凝膠10g,用刮痧板以髕骨為中心上下10cm范圍,均勻涂抹于患膝(包括乆窩部),每日早晚2次。連續(xù)使用3個療程。對照組:患者自取赤木洗劑藥包100g,加2L純凈水充分水煮熬制、反復(fù)過慮去渣得到赤木洗劑藥液,每次使用時首先將加熱藥液,加熱到病人皮膚能承受的溫度。然后折疊好的厚度大小適中的紗布用藥液浸泡濕備用,患者伸膝,將浸泡濕的紗布敷于以髕骨為中心上下10cm范圍,每次30min,紗布溫度低時予以更換,每日早晚2次,燙洗完畢后將藥液裝好置于冰箱保存。每包可重復(fù)加溫使用10次。連續(xù)使用3個療程。分別于治療前、治療后觀察記錄兩組病人的疼痛評分、膝關(guān)節(jié)Lysholm評分和關(guān)節(jié)功能分級;觀察記錄治療開始后兩組病人第1、5、10、20、30天的皮膚刺激征情況。對收集到的數(shù)據(jù)使用SPSS20.0軟件進(jìn)行統(tǒng)計(jì)學(xué)分析,計(jì)量資料采用t檢驗(yàn)或方差分析,計(jì)數(shù)資料應(yīng)用卡方或秩和檢驗(yàn)。結(jié)果:共收集納入病人40例,其中實(shí)驗(yàn)組有1例自行服用干擾藥物退出,對照組有2例因皮膚過敏暫停用藥退出,實(shí)際完成病例37例。實(shí)驗(yàn)組平均治療操作時間比對照組短(P0.05),操作更快捷簡便;實(shí)驗(yàn)組和對照組的疼痛緩解效果相當(dāng)(P0.05);對照組皮膚刺激性大于實(shí)驗(yàn)組(P0.05);實(shí)驗(yàn)組和對照組的膝關(guān)節(jié)功能分級改善效果相當(dāng)(P0.05);實(shí)驗(yàn)組和對照組的膝關(guān)節(jié)功能活動改善程度相當(dāng)(P0.05);癥狀體征療效評定總有效率:實(shí)驗(yàn)組89.47%,對照組83.33%。結(jié)論:赤木洗劑凝膠對于早期瘀血阻滯型膝骨性關(guān)節(jié)炎有較好的療效,且其使用安全、方便、快捷,可以在臨床上推廣使用。
[Abstract]:Objective: to observe the clinical efficacy and safety of Chimu lotion gel in the treatment of early knee osteoarthritis, summarize the characteristics, advantages and disadvantages of this medicine, and provide a theoretical basis for the clinical application of Chimu lotion gel in the treatment of this type of knee osteoarthritis.To popularize the clinical application of the traditional Chinese medicine gel type.Methods: a total of 40 cases of knee osteoarthritis with early blood stasis block type were collected and divided into experimental group and control group from February 2016 to August 2016 in three departments of bone and joint of Wendeng whole Bone Hospital of Shandong Province.The patients in both groups were given glucosamine sulfate capsule 0.628 gtid simultaneously. The patients in the experimental group were treated with Chimu lotion gel and the patients in the control group were treated with Chimu lotion. The patients in the control group were treated with Chimu lotion for a course of 10 days for 3 consecutive courses.Experimental group: the skin of the affected knee was cleaned with wet and warm towel before each treatment, and the skin of the affected knee was cleaned with the gel of Chimu lotion for 10 g. The upper and lower 10cm range of the patella was taken as the center of the palpation plate with the guesta plate. The skin was evenly smeared on the affected knee (including human nests, twice a day).Continuous use of 3 courses of treatment.The control group: the patients took 100 g of Chimu lotion package, added 2L pure water to boil and stay up, and repeatedly removed the slag to get the Chimu lotion solution. Each time, the heating solution was heated to the temperature that the patient skin could bear.Then the folded gauze of moderate thickness was soaked in the medicine solution, and the patient extended his knees. The wet gauze was applied to the upper and lower 10cm area centered on the patella. Each time for 30 minutes, the gauze was changed when the temperature of the gauze was low, twice a day, twice a day.After ironing and washing, put the medicine in the refrigerator and store it.Each package can be reheated 10 times.Continuous use of 3 courses of treatment.The pain score, knee joint Lysholm score and joint function grade were recorded before and after treatment, and the skin irritation symptoms of the two groups were recorded on the 30th day after treatment.The collected data were analyzed by SPSS20.0 software, the data were measured by t test or variance analysis, and the count data were analyzed by chi-square or rank sum test.Results: a total of 40 patients were included in the study group. One patient in the experimental group withdrew from taking interference drugs on his own and two patients in the control group were suspended because of skin allergy. 37 cases were actually completed.The average time of treatment in the experimental group was shorter than that in the control group (P 0.05), and the operation was faster and simpler than that in the control group.The pain relief effect of the experimental group and the control group was similar to that of the control group (P 0.05); the skin irritation of the control group was greater than that of the experimental group (P 0.05); the knee joint function grade of the experimental group and the control group was improved by P0.05; the function of the knee joint was improved in the experimental group and the control group.The total effective rate was 89.47 in the experimental group and 83.33 in the control group.Conclusion: Chimu lotion gel has good curative effect on early blood stasis type knee osteoarthritis, and its use is safe, convenient and quick, and can be popularized in clinic.
【學(xué)位授予單位】：福建中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R274.9

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