發(fā)布時間：2018-04-13 18:11

  本文選題：多囊卵巢綜合征 + Betatrophin��； 參考：《河北醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:通過測定多囊卵巢綜合征患者血清betatrophin水平及對betatrophin與生殖內(nèi)分泌激素及糖脂代謝紊亂的關(guān)系研究,明確betatrophin與多囊卵巢綜合征之間的關(guān)系,探討伴有糖脂代謝紊亂的多囊卵巢綜合征的發(fā)病機制,為多囊卵巢綜合征患者的診斷提供依據(jù)。方法:1選2016年3月-2016年12月于河北醫(yī)科大學(xué)第一醫(yī)院生殖醫(yī)學(xué)科門診就診的20-40歲的患者,入組患者3個月內(nèi)未使用過影響體內(nèi)激素和糖脂水平的藥物,無其他內(nèi)分泌代謝疾病。實驗組患者符合2003年鹿特丹會議關(guān)于女性PCOS的診斷要求,對照組為非PCOS患者,各20例。對照組患者記錄患者年齡,測量患者的身高、體重、腰圍、臀圍,測定激素六項、AMH,由同一醫(yī)生行陰道超聲檢查;觀察組除測量對照組的指標外,需要加測雄烯二酮、脫氫表雄酮、性激素結(jié)合蛋白,75g葡萄糖耐量試驗及胰島素釋放試驗、生化全項等,并留取外周靜脈血血清,放置-20℃冰箱保存,用ELISA方法,測定血清betatrophin水平。2將患者的臨床資料及各指標測量值記錄于excel表格中,用spss21.0對數(shù)據(jù)進行統(tǒng)計分析。結(jié)果:1與對照組相比,PCOS患者身高、年齡及各體重指標均無明顯統(tǒng)計學(xué)差異(P0.05)。2在生殖內(nèi)分泌指標方面,PCOS患者血清抗繆勒氏管激素、促黃體生成素、總睪酮水平顯著升高(P0.01),雄烯二酮明顯增高,性激素結(jié)合蛋白處于正常范圍低值。PCOS組患者表現(xiàn)出更為嚴重的糖脂代謝紊亂。3 PCOS組血清betatrophin水平較對照組顯著升高(P0.05);超重或肥胖組PCOS患者血清betatrophin水平高于體重正常組(P0.05),脂肪中心性分布組PCOS患者血清betatrophin水平高于非中心性分布組(P0.05),高雄激素組PCOS患者血清betatrophin水平高于非高雄激素組(P0.05),胰島素抵抗組PCOS患者血清betatrophin水平高于非胰島素抵抗組(P0.05),脂代謝異常組PCOS患者血清betatrophin水平高于非脂代謝異常組(P0.05)。4 Betatrophin與PCOS患者體重指數(shù)呈正相關(guān)(P0.05);與促黃體生成素及促黃體生成素/促卵泡激素比值、雄烯二酮、游離睪酮指數(shù)呈正相關(guān)(P0.05),且與性激素結(jié)合蛋白呈負相關(guān)(P0.05);在糖脂代謝方面,與甘油三酯、空腹胰島素水平、HOMA-IR、2h血糖呈正相關(guān)(P0.05)。結(jié)論:1多囊卵巢綜合征患者血清betatrophin水平明顯增高。2不同類型多囊卵巢綜合征患者血清betatrophin水平不同。隨著患者體重增加,血清betatrophin水平不斷升高;伴有高雄激素血癥的多囊卵巢綜合征患者血清betatrophin水平明顯增高;伴有糖脂代謝紊亂的多囊卵巢綜合征患者血清betatrophin水平明顯增高。3 Betatrophin有望成為一個多囊卵巢綜合征的監(jiān)測指標。
[Abstract]:Objective: to study the relationship between betatrophin and reproductive endocrine hormone and glycolipid metabolism disorder in patients with polycystic ovary syndrome (PCOS) by measuring the level of serum betatrophin, and to clarify the relationship between betatrophin and polycystic ovary syndrome (PCOS).To explore the pathogenesis of polycystic ovary syndrome (PCOS) with glucose and lipid metabolism disorder, and to provide evidence for diagnosis of PCOS.Methods from March 2016 to December 2016, patients aged 20 to 40 years old from the Department of Reproductive Medicine of the first Hospital of Hebei Medical University were selected. The patients in the group had not used any drugs affecting the levels of hormones and lipids in the body and no other endocrine and metabolic diseases.The patients in the experimental group were in accordance with the diagnostic requirements of the 2003 Rotterdam conference on female PCOS, and the control group were 20 cases of non-PCOS patients.The patients in the control group recorded their age, measured their height, weight, waist circumference, hip circumference, measured the six hormones AMH, and performed vaginal ultrasound examination by the same doctor; the observation group, in addition to measuring the indexes of the control group, needed to add androstenedione.Dehydroepiandrosterone, 75g glucose tolerance test, insulin release test, biochemistry test, etc. The peripheral venous blood serum was retained and stored in -20 鈩，

本文編號：1745630